1. Capsiate Intake with Exercise Training Additively Reduces Fat Deposition in Mice on a High-Fat Diet, but Not without Exercise Training
- Author
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Kiwon Lim, Hun-Young Park, Jisu Kim, Jongbeom Seo, and Deunsol Hwang
- Subjects
Male ,0301 basic medicine ,obesity ,Adipose tissue ,capsaicin ,lcsh:Chemistry ,Mice ,0302 clinical medicine ,capsiate ,energy expenditure ,Treadmill ,lcsh:QH301-705.5 ,Spectroscopy ,Mice, Inbred ICR ,General Medicine ,Exercise Therapy ,Computer Science Applications ,adipose tissue ,medicine.anatomical_structure ,Energy expenditure ,medicine.medical_specialty ,Diet, High-Fat ,Article ,Catalysis ,Inorganic Chemistry ,03 medical and health sciences ,Physical Conditioning, Animal ,Internal medicine ,medicine ,Animals ,Resting energy expenditure ,Physical and Theoretical Chemistry ,skeletal muscle ,Molecular Biology ,adrenoceptor ,030109 nutrition & dietetics ,business.industry ,Organic Chemistry ,abdominal fat ,Skeletal muscle ,030229 sport sciences ,Metabolism ,medicine.disease ,Obesity ,Endocrinology ,lcsh:Biology (General) ,lcsh:QD1-999 ,Basal metabolic rate ,Anti-Obesity Agents ,Basal Metabolism ,business ,exercise training ,metabolism - Abstract
While exercise training (ET) is an efficient strategy to manage obesity, it is recommended with a dietary plan to maximize the antiobesity functions owing to a compensational increase in energy intake. Capsiate is a notable bioactive compound for managing obesity owing to its capacity to increase energy expenditure. We aimed to examine whether the antiobesity effects of ET can be further enhanced by capsiate intake (CI) and determine its effects on resting energy expenditure and metabolic molecules. Mice were randomly divided into four groups (n = 8 per group) and fed high-fat diet. Mild-intensity treadmill ET was conducted five times/week, capsiate (10 mg/kg) was orally administered daily. After 8 weeks, resting metabolic rate and metabolic molecules were analyzed. ET with CI additively reduced the abdominal fat rate by 18% and solely upregulated beta-3-adrenoceptors in adipose tissue (p = 0.013) but did not affect the metabolic molecules in skeletal muscles. Surprisingly, CI without ET significantly increased the abdominal fat rate (p = 0.001) and reduced energy expenditure by 9%. Therefore, capsiate could be a candidate compound for maximizing the antiobesity effects of ET by upregulating beta-3-adrenoceptors in adipose tissue, but CI without ET may not be beneficial in managing obesity.
- Published
- 2021