1. Advanced Drug Delivery Technologies for Enhancing Bioavailability and Efficacy of Risperidone.
- Author
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Rathi R, Mehetre NM, Goyal S, Singh I, Huanbutta K, and Sangnim T
- Subjects
- Humans, Antipsychotic Agents pharmacokinetics, Antipsychotic Agents chemistry, Antipsychotic Agents administration & dosage, Animals, Solubility, Drug Carriers chemistry, Drug Carriers pharmacokinetics, Nanoparticles chemistry, Risperidone pharmacokinetics, Risperidone chemistry, Risperidone administration & dosage, Biological Availability, Drug Delivery Systems methods
- Abstract
Multidisciplinary research has been conducted on novel drug delivery technologies to maximize therapeutic advantages while curtailing undesirable reactions. Drugs under BCS Class II often have a low bioavailability because the dissolution phase limits the absorption efficiency. In this review, risperidone was used as a pharmacological model to examine the impact of solubility enhancement at the primary administration site for such pharmaceuticals. For tackling drug-related pertains like disease diagnostics, therapy, and prophylactic measures at the cellular or molecular levels, implementing nanocarriers in therapeutics has significant potential. The comprehensive pharmaceutical compositions of risperidone nano-microparticles that have been developed to alleviate psychosis are highlighted in the study, which also illustrates potential future developments in such domains., Competing Interests: The authors report no conflicts of interest in this work., (© 2024 Rathi et al.) more...
- Published
- 2024
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