1. Application of spray granulation for conversion of mixed phospholipid-bile salt micelles to dry powder form: influence of drug hydrophobicity on nanoparticle reagglomeration
- Author
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Qingyuan Lv, Xianyi Li, Bao-de Shen, Jin-xia Bai, He Xu, Ling Dai, Jin Han, Chengying Shen, and Hai-Long Yuan
- Subjects
Absorption (pharmacology) ,cucurbitacin B ,glycyrrhizin ,Male ,Materials science ,Chemistry, Pharmaceutical ,Biophysics ,Phospholipid ,Pharmaceutical Science ,Administration, Oral ,Biological Availability ,Bioengineering ,fluid bed granulation ,Micelle ,Dosage form ,Biomaterials ,Bile Acids and Salts ,chemistry.chemical_compound ,Dogs ,Drug Stability ,International Journal of Nanomedicine ,In vivo ,Drug Discovery ,Animals ,Solubility ,Desiccation ,Particle Size ,Fluid Bed Granulation ,Micelles ,Phospholipids ,Original Research ,Chromatography ,Organic Chemistry ,mixed phospholipid-bile salt micelles ,General Medicine ,poorly water soluble drugs ,Glycyrrhizic Acid ,Triterpenes ,Nanomedicine ,chemistry ,Nanoparticles ,Particle size ,Powders ,Hydrophobic and Hydrophilic Interactions - Abstract
Qingyuan Lv,1 Xianyi Li,2 Baode Shen,1 He Xu,1 Chengying Shen,1 Ling Dai,1 Jinxia Bai,1 Hailong Yuan,1 Jin Han11Department of Pharmacy, 302 Military Hospital, 2Institute for Drug and Instrument Control, Health Department, General Logistics Department of People's Liberation Army, Beijing, People's Republic of ChinaAbstract: The aim of this study was to investigate the feasibility of using spray granulation as a drying method to convert phospholipid (PL)-sodium deoxycholate (SDC)-mixed micelles (MMs) containing a water-insoluble drug to a solid dosage form and to evaluate how drugs with significantly different physicochemical properties affect the spray granulation process and subsequent in vitro and in vivo processes. Cucurbitacin B (Cu B) and glycyrrhizin (GL) were used as the model drugs. After spray granulation, the dried Cu B-PL/SDC-MM powder was completely redispersible within 15 minutes in vitro. Meanwhile, the area under the curve during 24 hours (AUC0–24) and peak serum concentration from the dried powder were significantly (P
- Published
- 2014