1. Assessment of TREM2 rs75932628 variant’s association with Parkinson’s disease in a Greek population and Meta-analysis of current data
- Author
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Dimitrios Rikos, Athina-Maria Aloizou, Alexandros G. Brotis, Evagelos Sakalakis, Vasileios Siokas, Efthimios Dardiotis, Dimitrios P. Bogdanos, Georgios M. Hadjigeorgiou, and Zisis Tsouris
- Subjects
Male ,0301 basic medicine ,Parkinson's disease ,Disease ,Biology ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Receptors, Immunologic ,Association (psychology) ,Aged ,Genetics ,Membrane Glycoproteins ,Polymorphism, Genetic ,Greece ,TREM2 ,General Neuroscience ,Neurodegeneration ,Genetic variants ,Parkinson Disease ,General Medicine ,Middle Aged ,medicine.disease ,030104 developmental biology ,Case-Control Studies ,Meta-analysis ,Female ,Greek population ,030217 neurology & neurosurgery - Abstract
Α number of genetic variants are considered to confer susceptibility to Parkinson's disease (PD). Rs75392628 (R47H), a rare variant of TREM2 gene, has been linked to PD, although its role on PD remains conflicting.Detection of a possible contribution of rs75392628 variant of TREM2 gene to PD risk.A total of 358 PD patients and 358 healthy controls genotyped for rs75392628. In addition, a meta-analysis was performed by merging our results with those from previous studies.The rare variant of rs75932628 (47H) of TREM2 gene was not detected on cohort. Meta-analysis of a total of 9271 PD cases and 9777 controls across 14 independent PD data sets from 9 studies, including the present study, did not show any statistically significant effect of rs75392628 on PD risk (ORRs75392628 TREM2 variant is rather unlikely to be a major genetic risk contributor of PD.
- Published
- 2020
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