1. Methylenetetrahydrofolate reductase 677 C->T polymorphism: A link between birth weight and insulin resistance in obese adolescents
- Author
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Jean-Claude Guilland, Genevieve Potier de Courcy, Jean-Pierre Nicolas, and Marie-Laure Frelut
- Subjects
Blood Glucose ,Male ,Aging ,medicine.medical_treatment ,Body Mass Index ,Gene Frequency ,Risk Factors ,Birth Weight ,Insulin ,Child ,Nutrition and Dietetics ,biology ,Health Policy ,Homozygote ,Age Factors ,Phenotype ,Child, Preschool ,Female ,France ,Heterozygote ,medicine.medical_specialty ,Adolescent ,Birth weight ,Polymorphism, Single Nucleotide ,Risk Assessment ,Insulin resistance ,Internal medicine ,medicine ,Humans ,Genetic Predisposition to Disease ,Obesity ,Allele frequency ,Methylenetetrahydrofolate Reductase (NADPH2) ,Analysis of Variance ,business.industry ,Infant, Newborn ,Public Health, Environmental and Occupational Health ,Infant ,Heterozygote advantage ,medicine.disease ,digestive system diseases ,Endocrinology ,Methylenetetrahydrofolate reductase ,Pediatrics, Perinatology and Child Health ,biology.protein ,Insulin Resistance ,business ,Body mass index - Abstract
The goal of this study is to determine whether cardiovascular risk and the methylenetetrahydrofolate reductase 677 C-T polymorphism (MTHFR), an enzyme involved in folate metabolism and in epigenetics, are linked in morbidly obese non-diabetic adolescents. One-hundred and thirteen obese (BMI = 39.1 ± 6.4 kg/m(2)) adolescents aged 14.4 ± 1.5 years were investigated before entering a weight reduction program. Information on growth obtained from individual health records was available at birth (n = 107), 1 (n = 102), 2 (n = 106), 4 (n = 91) and 8 (n = 73) years of age. Fifty-nine subjects were heterozygote (CT, 52.2%) and 8 were homozygote for the mutation (TT, 7.0%). Birth weights were lower in TT (2.95 ± 0.48 kg, p = 0.004) than in CC (3.34 ± 0.43 kg) and CT (3.38 ± 0.50 kg) subjects, as well as birth lengths (CC: 0.50 ± 0.02 m, CT : 0.50 ± 0.02 m, TT: 0.47 ± 0.03 m, p = 0.01). These differences persisted until 1 year of age. Median and mean fasting glycaemia were similar. Insulin levels were higher in TT (median: 26.4 UI/mL) than in CC (median: 15.0 UI/mL) or CT (median: 16.0 UI/mL) (p = 0.017) subjects, as well as HOMA IR (p = 0.04). Body composition, blood pressure, plasma lipids, homocysteine and leptin concentrations were similar among the three genotypes in both boys and girls. The common 677 C-T mutation seems therefore to represent a link between altered early growth and enhanced degree of insulin resistance that occurs later in obese adolescents.
- Published
- 2011
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