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Newborn ear deformity can be performed through Earwell infant ear correction system as a non-surgical treatment to avoid plastic surgery. In the newborn period, the auricle is soft and the cartilage is plastic, the deformed auricle shape can be treated by mechanical action. From April 2016 to December 2018, we selected the patients who underwent Earwell non-invasive correction system in Eye & ENT Hospital of Fudan University for newborn ear deformities, and analyze the treatment age, treatment time, efficiency and complication of these patients. There were 105 patients with 141 ears underwent Earwell non-invasive correction system for newborn ear deformities. The average age for treatment is 2.16 ± 2.28 months (0.23–12.0 months). The average treatment time is 1.14 ± 0.57 months (0.33–4.0 months). The treatment outcomes show 109 ears get excellent results, 27 ears good results and 5 ears poor results. For complications, there were 6 patients had localized skin rash and 5 had skin lesion which were cured after 3–5 days. Nine patients had different degree of recurrence. The treatment age less than 6 weeks had a better results than treatment age old than 6 weeks (χ2 = 4.48, p < 0.05). Except 5 poor results patients, the treatment efficiency is 96.4% (136/141) in this study. The Earwell infant ear correction system is proven to be a simple, non-invasive, high-efficiency, low-cost treatment method, which is more effective than traditional plastic surgery, and treatment efficiency of different types ear deformities can reach more than 95% in China. It is important to ensure the early treatment during the first 6 weeks. [ABSTRACT FROM AUTHOR]

Objective Although congenital microtia has been reported in various studies, little is known about the etiology of isolated and sporadic cases. The aim was to analyze potential risk factors for isolated and sporadic microtia using case–control study in East China. Methods The study analyzed data from the hospital-based recruitment for deliveries between 2007 and 2013. Nine hundred eleven patients with microtia enrolled in the phenotypic characterization analysis, and then were adjusted by sex, age, region, syndrome and family history to compare with 562 random normal controls for potential risk factors. Results Microtia is observed more often in males (69.7%), and the cases were typically unilateral (74.0%), right-sided (57.2%), sporadic (92.0%) and isolated (69.5%). Mothers of children with microtia were more likely to have suffered a periconceptional cold-like syndrome as well as to have had a history of previous spontaneous abortion. Inflammatory infection (aOR, 3.56; 95% CI, 2.07–6.13) and chemical exposure (aOR, 2.77; 95% CI, 1.78–4.32) was associated with a higher risk of microtia. However, threatened abortion was not the risk factor (aOR, 1.14; 95% CI, 0.78–1.67), using progesterone may increase the risk (aOR, 1.92; 95% CI, 1.03–3.59). Conclusion The results of phenotypic characterization analysis were similar to other studies. By controlling the effects of potential confounders, some risk factors could be teratogens of isolated and sporadic microtia in East China. [ABSTRACT FROM AUTHOR]