1. Tumor targeted combination therapeutic system for the effective treatment of drug resistant triple negative breast cancer.
- Author
-
Cai, Zedong, Huan, Meng-Lei, Zhang, Yao-Wen, Zhao, Ting-Ting, Han, Tian-Yan, He, Wei, Zhou, Si-Yuan, and Zhang, Bang-Le
- Subjects
- *
TRIPLE-negative breast cancer , *NANOMEDICINE , *BREAST , *PHOTOTHERMAL conversion , *BREAST cancer - Abstract
Tumor targeted combination nanoparticles was designed as effective therapeutic system for the drug resistant triple negative breast cancer and the anti-tumor effect in vitro and in vivo was demonstrated. [Display omitted] Breast cancer has become the malignant tumor with the largest incidence, especially the drug resistant triple negative breast cancer (TNBC). The combination therapeutic system can play a better role in resisting drug resistant TNBC. In this study, dopamine and tumor targeted folic acid modified dopamine were synthesized as carrier materials to construct melanin-like tumor targeted combination therapeutic system. The optimized nanoparticles of CPT/Fe@PDA-FA10 with efficient loading of camptothecin and iron was achieved, which showed tumor targeted delivery ability, pH sensitive controlled release, effective photothermal conversion performance and excellent anti-tumor efficacy in vitro and in vivo. CPT/Fe@PDA-FA10 plus laser could significantly kill the drug resistant tumor cells, inhibit the growth of the orthotopic drug resistant triple negative breast cancer through apoptosis/ferroptosis/photothermal treatment, and had no significant side effects on the main tissues and organs. This strategy provided a new idea for the construction and clinical application of triple-combination therapeutic system as effective treatment for drug resistant triple negative breast cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF