1. Effect of dose-rate on induction of neoplastic transformation in vitro by low doses of 232 MeV protons
- Author
-
J. Leslie Redpath, Rubina Kapadia, Xyoan Y. Lao, and Elmore E
- Subjects
Risk ,Neoplasms, Radiation-Induced ,Hybrid Cells ,Biology ,Radiation Dosage ,Neoplasms ,health services administration ,mental disorders ,Humans ,Linear Energy Transfer ,Radiology, Nuclear Medicine and imaging ,Neoplastic transformation ,Solar Activity ,Radiological and Ultrasound Technology ,business.industry ,Low dose ,Dose-Response Relationship, Radiation ,Fibroblasts ,humanities ,In vitro ,Dose–response relationship ,Cell Transformation, Neoplastic ,Protons ,Nuclear medicine ,business ,Dose rate ,HeLa Cells - Abstract
Purpose: To determine the effect of dose-rate on induction of neoplastic transformation in vitro by low doses of 232 MeV protons.Materials and methods: The experimental system used was the human hybrid cell assay. The dose-rates examined were 50 cGy/min and 20 cGy/h. The dose-rate 20 cGy/h was chosen as this is in the range of the maximum dose-rate that can be experienced in an unshielded space environment following a solar flare. At low dose-rate (LDR), doses from 0.5–100 cGy were studied. At high dose rate (HDR), the dose range was 0.5–200 cGy.Results: The data indicated no significant differences between the two dose-rates at doses up to 100 cGy.Conclusion: For the endpoint of neoplastic transformation in vitro, high dose-rate data may be sufficient to estimate low dose-rate effects (20 cGy/h) in the dose range up to 100 cGy from 232 MeV protons. The data are of relevance to risk estimation for space travel.
- Published
- 2011
- Full Text
- View/download PDF