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Your search keyword '"Li, Ye-Xiong"' showing total 30 results
Start Over Author "Li, Ye-Xiong" Journal international journal of radiation oncology*biology*physics
30 results on '"Li, Ye-Xiong"'

1. Dose-Volume Predictors for Radiation Esophagitis in Patients With Breast Cancer Undergoing Hypofractionated Regional Nodal Radiation Therapy

Author

Wang, Dan-Qiong, Zhang, Na, Dong, Li-Hua, Zhong, Ya-Hua, Wu, Hong-Fen, Zhong, Qiu-Zi, Jin, Jing, Hou, Xiao-Rong, Jing, Hao, Tang, Yu, Hu, Chen, Song, Yong-Wen, Liu, Yue-Ping, Qi, Shu-Nan, Tang, Yuan, Lu, Ning-Ning, Chen, Bo, Zhai, Yi-Rui, Zhang, Wen-Wen, Li, Ning, Fang, Hui, Li, Ye-Xiong, and Wang, Shu-Lian

Published
2023
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10. Patterns of Primary Tumor Invasion and Regional Lymph Node Spread Based on Magnetic Resonance Imaging in Early-Stage Nasal NK/T-cell Lymphoma: Implications for Clinical Target Volume Definition and Prognostic Significance

Author

Wu, Run-Ye, Liu, Kang, Wang, Wei-Hu, Jin, Jing, Song, Yong-Wen, Wang, Shu-Lian, Liu, Yue-Ping, Ren, Hua, Fang, Hui, Liu, Qing-Feng, Yang, Yong, Chen, Bo, Qi, Shu-Nan, Lu, Ning-Ning, Tang, Yu, Tang, Yuan, Li, Ning, Ouyang, Han, and Li, Ye-Xiong

Published
2017
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30. [Prognostic and Predictive Value of a Modified Diagnostic Biopsy-Adapted Immunoscore in Patients with Rectal Cancer After Neoadjuvant Treatment- a translational study from the STELLAR trial].

Author

Zeng Q, Yang YX, Tang Y, Li N, Lu NN, Wang SL, Li YX, Jin J, Zou SM, and Liu WY

Abstract

Background: The purpose of this study was to assess the prognostic significance of the modified diagnostic biopsy-adapted immunoscore (mIS b ) in determining the outcomes for patients with locally advanced rectal cancer (LARC) in a neoadjuvant setting., Methods: We included 181 LARC patients from a single subcenter of a prospective study comparing total neoadjuvant therapy (TNT) based on short-course radiotherapy with long-term chemoradiotherapy (CRT). Tumor biopsies at baseline were stained for CD8+ and CD3+ T-cell densities. The mIS b was developed using mean percentile of CD8+ T-cell density and CD8/CD3 ratios. Patients were classified into low (0%-25%), intermediate (>25%-70%), and high (>70%-100%) in both groups. The relativity among different lymphocytes and their correlation with survival were illustrated. Survival analyses and Cox regression models were used to compare the prognostic value of mIS b and IS b for survival outcomes, and to assess the role of mIS b in TNT and CRT subgroups respectively., Results: In this study, 151 (83.4%) patients received surgery and 30 (16.6%) followed a watch and wait strategy. A strong correlation was found between CD8+ and CD3+ T-cell densities (R=0.86, P<0.001), while a weak correlation witnessed between CD8+ and CD8/CD3 ratio (R=0.45). The 3-year disease-free survival (DFS) for the entire cohort was 69.9%, with 57.2%, 68.6%, and 85.5% for the low, intermediate, and high mIS b groups respectively (P=0.01), while IS b failed to distinguish survival outcomes. Multivariate analysis revealed mIS b to be an independent prognostic factor for DFS in surgically treated patients (P=0.01). Specifically, patients with high mIS b score showed longer PFS than other subgroups in the TNT cohort (P=0.049), but no significant difference was found in the CRT population., Conclusions: In this study, mIS b demonstrates significant prognostic value in LARC patients receiving preoperative therapies, especially in the TNT subgroup. These findings may help tailor the intensity of neoadjuvant therapy for patients., Competing Interests: Declaration of competing interest None., (Copyright © 2024. Published by Elsevier Inc.)

Published
2024
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