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Your search keyword '"Li, Yimei"' showing total 15 results
Start Over Author "Li, Yimei" Publication Year Range Last 50 years Language english Journal international journal of radiation oncology, biology, physics
15 results on '"Li, Yimei"'

3. Pre- and Posttherapy Risk Factors for Vasculopathy in Pediatric Patients With Craniopharyngioma Treated With Surgery and Proton Radiation Therapy

Author

Lucas, John T., Jr, Faught, Austin M., Hsu, Chih Yang, Wilson, Lydia J., Guo, Yian, Li, Yimei, Khan, Raja, Becksfort, Jared B., LeVine, David A., Ismael, Yousef, Darrow, Kaleb, Moskvin, Vadim P., Pirlepesov, Fakhriddin, Klimo, Paul, Elijovich, Lucas, Indelicato, Daniel J., Boop, Fredrick A., and Merchant, Thomas E.

Published
2022
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8. Implications of Image-Defined Risk Factors and Primary-Site Response on Local Control and Radiation Treatment Delivery in the Management of High-Risk Neuroblastoma: Is There a Role for De-escalation of Adjuvant Primary-Site Radiation Therapy?

Author

Lucas, John T., Jr., McCarville, M. Beth, Cooper, David A., Doubrovin, Mikhail, Wakefield, Daniel, Santiago, Teresa, Li, Yimei, Li, Xingyu, Krasin, Matthew, Santana, Victor, Furman, Wayne, and Davidoff, Andrew M.

Published
2019
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15. Prognostic Relevance of Treatment Failure Patterns in Pediatric High-Grade Glioma: Is There a Role for a Revised Failure Classification System?

Author

Jr.lucas, John T., Cooper, David A., Hwang, Scott, Tinkle, Christopher, Li, Xingyu, Li, Yimei, Orr, Brent, Merchant, Thomas E., Broniscer, Alberto, and Lucas, John T Jr

Subjects
*GLIOMA treatment, *CANCER invasiveness, *RADIOTHERAPY, *BRAIN tumor treatment, *MAGNETIC resonance imaging, *ANTINEOPLASTIC agents, *BRAIN tumors, *CLINICAL trials, *COMPARATIVE studies, *GLIOMAS, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *NEURORADIOLOGY, *PROGNOSIS, *RADIATION doses, *REGRESSION analysis, *RESEARCH, *EVALUATION research, *TREATMENT effectiveness, *DISEASE progression
Abstract

Purpose: We sought to investigate the pattern of treatment failure with respect to anatomic extent, radiation dose, and criteria for failure according to the Response Assessment in Neuro-Oncology (RANO). We evaluated the corresponding prognostic significance of these factors in patients with pediatric high-grade glioma (pHGG).Methods and Materials: Fifty-six patients with pHGG were enrolled in an institutional phase 1 to 2 prospective trial that included maximal safe resection and radiation therapy with concurrent and adjuvant erlotinib. The radiation therapy dose administered was 54 to 59.4 Gy at 1.8 Gy/d. Tumor progression was defined according to clinical symptoms and imaging features and was classified in relation to the original extent of the tumor, radiation prescription target volume coverage, and RANO criteria (RANOc).Results: With a median follow-up period of 90 months (range, 70-124 months), progression occurred in 48 patients (85.7%) while 8 (14.3%) were without progression. Central failure represented 42.6% of the total cohort, while in-field, marginal, and distant failures occurred in 7.4%, 9.3%, and 22.2%, respectively. Patients with biopsy or subtotal resection had increased rates of central failure and represented 14.81% and 16.67% of the total cohort, respectively. Tumor progression was classified as local, local plus distant, or distant. Among patients with local failure as a component of failure, 5 were considered to have marginal failure. Patients with frontal, temporal, and parietal disease had the highest rates of multifocal failure. A comparison between responses defined by RANOc demonstrated varied time to death (TTD) from progression.Conclusions: Pediatric high-grade glioma was shown to have high rates of central failure, particularly in cases with limited resection. Patients with central failure had a trend toward more prolonged TTD from failure relative to other failure patterns. The low marginal failure rates seen in this group suggest that less conservative radiation target margins may be possible. TTD from failure varied according to RANO type, suggesting that adult RANOc require modification before being applied to pHGG. [ABSTRACT FROM AUTHOR]

Published
2017
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