1. Usefulness of diffusion-weighted imaging in the localization of prostate cancer
- Author
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Yasuyuki Hamada, Mitsuhiko Kitaoka, Kazuhiro Katahira, Yasuyuki Yamashita, Shoji Morishita, Yoshiko Hayashida, Ryuichi Nishimura, Yasuko Suzuki, Toshinori Hirai, Ryuji Murakami, Hiroo Kajihara, Mika Kitajima, Kousuke Kitani, and Kazuo Awai
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,Sensitivity and Specificity ,Lesion ,Prostate cancer ,Prostate ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,False Positive Reactions ,cardiovascular diseases ,Radiation treatment planning ,Aged ,Retrospective Studies ,Observer Variation ,Prostatectomy ,Radiation ,medicine.diagnostic_test ,business.industry ,Radiation dose ,Prostatic Neoplasms ,Magnetic resonance imaging ,Middle Aged ,medicine.disease ,Radiation therapy ,medicine.anatomical_structure ,Diffusion Magnetic Resonance Imaging ,Oncology ,Radiology ,medicine.symptom ,Nuclear medicine ,business ,Diffusion MRI - Abstract
Purpose: Advances in high-precision radiation therapy techniques for patients with prostate cancer permit selective escalation of the radiation dose delivered to the dominant intraprostatic lesion and improve the therapeutic ratio. We evaluated the value of diffusion-weighted imaging (DWI) for dominant intraprostatic lesion assessment. Methods and Materials: The study population consisted of 23 patients with early prostate cancer. Before undergoing total prostatectomy, they were evaluated by means of magnetic resonance imaging, including DWI. T2-weighted imaging (T2WI) with and without DWI were retrospectively assessed by six independent observers. Imaging findings were compared with pathologic results from whole prostate specimens on a lesion-by-lesion basis. Results: Pathologic study identified 43 lesions in 23 patients. On magnetic resonance imaging, the six observers correctly identified 11-22 of 43 lesions (sensitivity, 26-51%) on T2WI alone and 20-31 (sensitivity, 47-72%) on T2WI plus DWI. Positive predictive values were 42-73% on T2WI alone and 58-80% on T2WI plus DWI. For all observers, detection was higher on combined T2WI and DWI than on T2WI alone. Conclusion: Because the addition of DWI to T2WI improves the detectability of prostate cancer, DWI may offer a promising new approach for radiation therapy planning.
- Published
- 2008