1. Infant brain tumors: incidence, survival, and the role of radiation based on Surveillance, Epidemiology, and End Results (SEER) Data.
- Author
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Bishop AJ, McDonald MW, Chang AL, and Esiashvili N
- Subjects
- Analysis of Variance, Black People statistics & numerical data, Brain Neoplasms ethnology, Brain Neoplasms mortality, Brain Neoplasms pathology, Choroid Plexus Neoplasms epidemiology, Choroid Plexus Neoplasms ethnology, Choroid Plexus Neoplasms mortality, Choroid Plexus Neoplasms pathology, Choroid Plexus Neoplasms radiotherapy, Ependymoma epidemiology, Ependymoma ethnology, Ependymoma mortality, Ependymoma pathology, Ependymoma radiotherapy, Female, Glioma epidemiology, Glioma ethnology, Glioma mortality, Glioma pathology, Glioma radiotherapy, Humans, Incidence, Infant, Male, Medulloblastoma epidemiology, Medulloblastoma ethnology, Medulloblastoma mortality, Medulloblastoma pathology, Medulloblastoma radiotherapy, Neoplasms, Germ Cell and Embryonal epidemiology, Neoplasms, Germ Cell and Embryonal ethnology, Neoplasms, Germ Cell and Embryonal mortality, Neoplasms, Germ Cell and Embryonal pathology, Neoplasms, Germ Cell and Embryonal radiotherapy, Neuroectodermal Tumors, Primitive epidemiology, Neuroectodermal Tumors, Primitive ethnology, Neuroectodermal Tumors, Primitive mortality, Neuroectodermal Tumors, Primitive pathology, Neuroectodermal Tumors, Primitive radiotherapy, Rhabdoid Tumor epidemiology, Rhabdoid Tumor ethnology, Rhabdoid Tumor mortality, Rhabdoid Tumor pathology, Rhabdoid Tumor radiotherapy, SEER Program, United States epidemiology, White People statistics & numerical data, Black or African American, Brain Neoplasms epidemiology, Brain Neoplasms radiotherapy
- Abstract
Purpose: To evaluate the incidence of infant brain tumors and survival outcomes by disease and treatment variables., Methods and Materials: The Surveillance, Epidemiology, and End Results (SEER) Program November 2008 submission database provided age-adjusted incidence rates and individual case information for primary brain tumors diagnosed between 1973 and 2006 in infants less than 12 months of age., Results: Between 1973 and 1986, the incidence of infant brain tumors increased from 16 to 40 cases per million (CPM), and from 1986 to 2006, the annual incidence rate averaged 35 CPM. Leading histologies by annual incidence in CPM were gliomas (13.8), medulloblastoma and primitive neuroectodermal tumors (6.6), and ependymomas (3.6). The annual incidence was higher in whites than in blacks (35.0 vs. 21.3 CPM). Infants with low-grade gliomas had the highest observed survival, and those with atypical teratoid rhabdoid tumors (ATRTs) or primary rhabdoid tumors of the brain had the lowest. Between 1979 and 1993, the annual rate of cases treated with radiation within the first 4 months from diagnosis declined from 20.5 CPM to <2 CPM. For infants with medulloblastoma, desmoplastic histology and treatment with both surgery and upfront radiation were associated with improved survival, but on multivariate regression, only combined surgery and radiation remained associated with improved survival, with a hazard ratio for death of 0.17 compared with surgery alone (p = 0.005). For ATRTs, those treated with surgery and upfront radiation had a 12-month survival of 100% compared with 24.4% for those treated with surgery alone (p = 0.016). For ependymomas survival was higher in patients treated in more recent decades (p = 0.001)., Conclusion: The incidence of infant brain tumors has been stable since 1986. Survival outcomes varied markedly by histology. For infants with medulloblastoma and ATRTs, improved survival was observed in patients treated with both surgery and early radiation compared with those treated with surgery alone., (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Published
- 2012
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