1. West meets East in genetics of ankylosing spondylitis.
- Author
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Li, Jing‐Xing, Wu, Xin, Lee, Yung‐Heng, and Xu, Huji
- Subjects
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ANKYLOSING spondylitis , *GENETICS , *T cell receptors , *HLA-B27 antigen , *UBIQUITIN-conjugating enzymes , *CELL receptors , *RUNX proteins , *MONONUCLEAR leukocytes - Abstract
MHC associations of ankylosing spondylitis in East Asians are complex and involve non-HLA-B27 HLA contributions. Ankylosing spondylitis (AS), a subtype of seronegative spondyloarthropathy, is a common inflammatory disease that affects the spine and sacroiliac joints of the pelvis, resulting in pain, stiffness, and eventually, joint fusion. (B) Percentage of identified major histocompatibility complex (MHC) and non-MHC loci linked with AS. The complicated genetics of AS were decoded using genome-wide association studies (GWAS).[[6]] Through GWAS, approximately 116 major histocompatibility complex (MHC) loci and 48 non-MHC loci have been linked with AS (Figure 1B). [Extracted from the article]
- Published
- 2023
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