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INTRODUCTION:The coronavirus disease 2019 (COVID-19) is caused by the virus SARS-CoV-2 and is declared as a global pandemic by the World Health Organization (WHO). There are many western and Chinese studies have done, but there is a need for research to evaluate the pattern of the haematological parameters of COVID-19 patients & predict requirement of Oxygen in the Indian population. MATERIALS AND METHODS: st A retrospective cross sectional study carried out on 150 COVID-19 positive patients admitted form 1 May th 2021 to 14 May 2021 in a tertiary care hospital, Smt. Kashibai Navale Medical College & General Hospital, India. RESULTS: The nal study population consisted of 150 patients. The Derived NLR and NLR & CRPhad higher specicity and positive predictive value. The accuracy of Derived NLR, NLR and CRPwas 66%, 64% and 63% respectively.The area under the ROC Curve (AUC) values of Derived NLR, NLR, and CRPindicates that there was a 65% probability that these signicant indicators were able to distinguish patients required oxygen or not (on room air). CONCLUSION: History of Diabetes, hypertension plays measure role as a prognostic factor in a COVID 19 Positive. But other hematological parameters like NLR, derived NLR, CRPferritin also plays measure role in predicting requirement of oxygen