1. The Effects of Plasmacytoid Dendritic Cell-Stimulative Lactic Acid Bacteria, Lactococcus lactis Strain Plasma, on Exercise-Induced Fatigue and Recovery via Immunomodulatory Action.
- Author
-
Takeshi Kokubo, Yuta Komano, Ryohei Tsuji, Daisuke Fujiwara, Toshio Fujii, and Osamu Kanauchi
- Subjects
- *
ANIMAL experimentation , *CYTOKINES , *DENDRITIC cells , *EXERCISE , *GRAM-positive bacteria , *HUMAN locomotion , *IMMUNOLOGICAL adjuvants , *MICE , *RISK assessment , *TRANSFORMING growth factors-beta , *TREADMILLS , *PROBIOTICS , *MUSCLE fatigue , *PHARMACODYNAMICS - Abstract
The unique lactic acid bacteria, Lactococcus lactis strain plasma (LC-Plasma), stimulates plasmacytoid dendritic cells, which play an important role in viral infection. The authors previously reported that LC-Plasma reduced the number of days athletes experienced cold-like symptoms and fatigue feelings after high-intensity exercise training; however, the mechanism was unclear. In this study, the authors investigated the effect of LC-Plasma on recovery from physical damage after single exercise on a treadmill in BALB/c mice model. Oral administration of LC-Plasma (AIN-93G + 0.029% LC-Plasma) for 4 weeks significantly improved the locomotor reduction after treadmill exercise. This effect was not detected in mice receiving Lactobacillus rhamnosus GG, representative probiotics strain. LC-Plasma also improved voluntary locomotor activity after exercise. Blood and muscle sample analysis indicated that LC-Plasma affects plasmacytoid dendritic cell activation, which, in turn, attenuates muscle degenerative genes and the concentration of fatigue-controlled cytokine transforming growth factor-β. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF