1. Resistance Training Does not have an Effect on Cognition or Related Serum Biomarkers in Nonagenarians: A Randomized Controlled Trial
- Author
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Gabriel Rodríguez-Romo, Jonatan R. Ruiz, Francisco-Javier Gil-Bea, Natalia Bustamante-Ara, José Antonio Serra-Rexach, Alejandro Lucia, Angel Cedazo-Minguez, and Carmen Fiuza-Luces
- Subjects
Male ,Ciencia ,Aging ,medicine.medical_specialty ,Envejecimiento ,Cognitive decline ,Salud ,Physical Therapy, Sports Therapy and Rehabilitation ,Peptidyl-Dipeptidase A ,law.invention ,Amyloid beta-Protein Precursor ,Cognition ,Elderly ,Randomized controlled trial ,law ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Muscle Strength ,Mini-mental state examination ,Leg press ,Aged, 80 and over ,Mini–Mental State Examination ,Epidermal Growth Factor ,biology ,medicine.diagnostic_test ,Tumor Necrosis Factor-alpha ,Physical activity ,business.industry ,Brain-Derived Neurotrophic Factor ,Resistance Training ,Angiotensin-converting enzyme ,Blood Proteins ,Ejercicio físico ,Blood proteins ,biology.protein ,Physical therapy ,Female ,Geriatric Depression Scale ,Cognitive function ,business ,Biomarkers - Abstract
The aim of this randomized controlled trial was to determine the effects of 8-week exercise-intervention on cognition and related serum biochemical markers in nonagenarians. We also studied the effects of a 4-week training cessation (‘detraining’) period on our study variables. Participants were randomly allocated to a standard-care (control) or intervention (exercise) group [n=20 (16 women)/group]. The intervention focused on supervised, light-to-moderate-intensity aerobic and resistance exercises (mainly leg press), and included 3 weekly sessions. Cognitive status was determined by the mini-mental state examination and geriatric depression scale. We analysed proteins with reported relation with mechanisms behind cognition changes such as serum levels of angiotensin converting enzyme, amyloid-precursor protein, epidermal growth factor, brain-derived neural factor and tumor necrosis factor. No significant change (P>0.05) in any of the variables studied was found following the exercise intervention compared with the standard-care group. Similarly, no significant changes (P>0.05) were observed following the detraining period compared with the standard-care group. Overall changes after the exercise intervention in serum biomarkers were not associated with changes in functional capacity and cognitive measures. An 8-week exercise intervention focusing on resistance exercises neither benefits cognitive function nor affects the levels of the serum proteins analysed in nonagenarians.
- Published
- 2014
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