1. Knowledge, attitudes and practices of West Africans on genetic studies of stroke: Evidence from the SIREN Study
- Author
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Lukman Owolabi, Isah Suleiman Yahaya, Morenikeji A. Komolafe, Taofeeq Sanni, Temitope Farombi, Andrew Bock-Oruma, Joseph Yaria, Ayodipupo Oguntade, Chidiebere Lucius Imoh, Rufus Akinyemi, Bruce Ovbiagele, Richard Efidi, Michael B. Fawale, Vincent Shidali, Peter Olowoniyi, Abdullahi Hamisu Dambatta, Josephine Akpalu, Ganiyu Amusa, Sulaiman Lakoh, Gregory Fakunle, Dorcas Owusu, Adesola Ogunniyi, Carolyn Jenkins, Mayowa O. Owolabi, Lambert Appiah, Paul Olowoyo, Kelechi Uwanruochi, Tiwari Hemant, Olaleye Adeniji, Philip M Kolo, Ezinne Uvere, Ezinne Melikam, Emmanuel O Sanya, Innocent Chukwuonye, Godwin Osaigbovo, Oyedunni Arulogun, Godwin Ogbole, Abiodun M. Adeoye, Taofiki Sunmonu, Olalekan I Oyinloye, Luqman Ogunjimi, Nasir Abdulkadir Tabari, Yahaya Obiabo, Phillip Oluleke Ibinaiye, Oladimeji Adebayo, Kolawole Wahab, Albert Akpalu, Mercy Faniyan, Fred Stephen Sarfo, Arti Singh, Joshua O. Akinyemi, Osi Adeleye, Philip Adebayo, Raelle Saulson, Olumayowa Aridegbe, Reginald Obiako, Ruth Laryea, Odo Chidi Joseph, Mulugeta Gebreziabher, Benedict Calys-Tagoe, and Matthew O. Akpa
- Subjects
Gerontology ,Adult ,Male ,Health Knowledge, Attitudes, Practice ,media_common.quotation_subject ,Developing country ,Black People ,Nigeria ,030204 cardiovascular system & hematology ,Ghana ,Literacy ,Article ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Surveys and Questionnaires ,medicine ,Humans ,cardiovascular diseases ,Stroke ,Developing Countries ,media_common ,Aged ,business.industry ,Middle Aged ,medicine.disease ,Siren (codec) ,West african ,Africa, Western ,Chronic disease ,Cross-Sectional Studies ,Neurology ,Socioeconomic Factors ,Female ,business ,030217 neurology & neurosurgery - Abstract
Background It is crucial to assess genomic literacy related to stroke among Africans in preparation for the ethical, legal and societal implications of the genetic revolution which has begun in Africa. Objective To assess the knowledge, attitudes and practices (KAP) of West Africans about stroke genetic studies. Methods A comparative cross-sectional study was conducted among stroke patients and stroke-free controls recruited across 15 sites in Ghana and Nigeria. Participants' knowledge of heritability of stroke, willingness to undergo genetic testing and perception of the potential benefits of stroke genetic research were assessed using interviewer-administered questionnaire. Descriptive, frequency distribution and multiple regression analyses were performed. Results Only 49% of 2029 stroke patients and 57% of 2603 stroke-free individuals knew that stroke was a heritable disorder. Among those who knew, 90% were willing to undergo genetic testing. Knowledge of stroke heritability was associated with having at least post-secondary education (OR 1.51, 1.25–1.81) and a family history of stroke (OR 1.20, 1.03–1.39) while Islamic religion (OR=0.82, CI: 0.72–0.94), being currently unmarried (OR = 0.81, CI: 0.70–0.92), and alcohol use (OR = 0.78, CI: 0.67–0.91) were associated with lower odds of awareness of stroke as a heritable disorder. Willingness to undergo genetic testing for stroke was associated with having a family history of stroke (OR 1.34, 1.03–1.74) but inversely associated with a medical history of high blood pressure (OR = 0.79, 0.65–0.96). Conclusion To further improve knowledge of stroke heritability and willingness to embrace genetic testing for stroke, individuals with less formal education, history of high blood pressure and no family history of stroke require targeted interventions.
- Published
- 2018