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Information Systems in the context of the health domain play a critical role. The evolution of the semantic web and knowledge management technologies in the last years set a new context for the exploitation of patient-centric strategies based on well-defined semantics and knowledge. In this paper we have two critical objectives. On the one hand to exploit the state of the art on Semantic Web and Knowledge Management (KM) approaches in the context of the health domain and on the other hand to underline the key challenges within the FP7 framework of the European Union for customised and personalised health services. [ABSTRACT FROM AUTHOR]