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Your search keyword '"N. Origlia"' showing total 2 results
Start Over Author "N. Origlia" Journal international journal of tissue reactions
2 results on '"N. Origlia"'

1. Inhibitory activity of the white wine compounds, tyrosol and caffeic acid, on lipopolysaccharide-induced tumor necrosis factor-alpha release in human peripheral blood mononuclear cells

Author

L, Giovannini, M, Migliori, C, Filippi, N, Origlia, V, Panichi, M, Falchi, A A E, Bertelli, and A, Bertelli

Subjects
Lipopolysaccharides, Caffeic Acids, Dose-Response Relationship, Drug, Tumor Necrosis Factor-alpha, Humans, Drug Synergism, Wine, Phenylethyl Alcohol, Cells, Cultured, Monocytes
Abstract

The objective of this study was to assess whether tyrosol and caffeic acid are able to inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha release. TNF is one of the most important cytokines involved in inflammatory reactions. The results show that both tyrosol and caffeic acid are able to inhibit LPS-induced TNF-alpha release from human monocytes, even at low doses. Their mechanisms of action are discussed and we conclude that high doses of the two compounds are not required to achieve effective inhibition of inflammatory reactions due to TNF-alpha release.

Published
2002

2. Inhibitory activity of the white wine compounds, tyrosol and caffeic acid, on lipopolysaccharide-induced tumor necrosis factor-alpha release in human peripheral blood mononuclear cells.

Author

Giovannini L, Migliori M, Filippi C, Origlia N, Panichi V, Falchi M, Bertelli AA, and Bertelli A

Subjects
Caffeic Acids administration & dosage, Cells, Cultured, Dose-Response Relationship, Drug, Drug Synergism, Humans, Phenylethyl Alcohol administration & dosage, Wine, Caffeic Acids pharmacology, Lipopolysaccharides pharmacology, Monocytes drug effects, Monocytes metabolism, Phenylethyl Alcohol analogs & derivatives, Phenylethyl Alcohol pharmacology, Tumor Necrosis Factor-alpha antagonists & inhibitors
Abstract

The objective of this study was to assess whether tyrosol and caffeic acid are able to inhibit lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-alpha release. TNF is one of the most important cytokines involved in inflammatory reactions. The results show that both tyrosol and caffeic acid are able to inhibit LPS-induced TNF-alpha release from human monocytes, even at low doses. Their mechanisms of action are discussed and we conclude that high doses of the two compounds are not required to achieve effective inhibition of inflammatory reactions due to TNF-alpha release.

Published
2002

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