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Your search keyword '"Kawakami, Satoru"' showing total 197 results
Start Over Author "Kawakami, Satoru" Journal international journal of urology
197 results on '"Kawakami, Satoru"'

1. Clinical outcomes of nivolumab plus ipilimumab in patients with metastatic non‐clear cell renal cell carcinoma: Real‐world data from a Japanese multicenter retrospective study.

Author

Izumi, Keita, Inoue, Masaharu, Washino, Satoshi, Shirotake, Suguru, Kagawa, Makoto, Takeshita, Hideki, Miura, Yuji, Hyodo, Yoji, Oyama, Masafumi, Kawakami, Satoru, Miyagawa, Tomoaki, Saito, Kazutaka, and Kageyama, Yukio

Subjects
RENAL cell carcinoma, NIVOLUMAB, TREATMENT effectiveness, IPILIMUMAB, ADVERSE health care events
Abstract

Objectives: Although nivolumab plus ipilimumab has become a standard treatment regimen for metastatic clear cell renal cell carcinoma (ccRCC), its efficacy in non‐clear cell carcinoma (nccRCC) has not been fully examined. In the current study, we evaluated the clinical outcomes of nivolumab plus ipilimumab in nccRCC compared with ccRCC. Methods: We retrospectively analyzed 22 patients with metastatic and/or locally advanced unresectable nccRCC who received nivolumab plus ipilimumab as a first‐line therapy and compared them with 107 patients with ccRCC. Objective response rate (ORR), progression‐free survival (PFS), overall survival (OS), and toxicity were compared between the nccRCC and ccRCC groups. Results: The histology of nccRCC included eight papillary, six unclassified, three chromophobe, two collecting duct carcinoma, and three other subtypes. Best objective response in nccRCC patients included three complete responses and five partial responses, resulting in an ORR of 36%, while that in ccRCC patients was 50% (p = 0.22). With a median follow‐up of 11.9 months, OS was significantly shorter in patients with nccRCC than in those with ccRCC (median 20.8 months vs. not reached, p = 0.04), while there was no significant difference in PFS (median 6.3 vs. 10.8 months, p = 0.21). Treatment‐related adverse events occurred in 14 (64%) nccRCC patients and 81 (76%) ccRCC patients. Conclusions: Combination treatment with nivolumab and ipilimumab demonstrated modest clinical efficacy in patients with nccRCC compared with patients with ccRCC, suggesting it could be a therapeutic option for metastatic nccRCC patients. [ABSTRACT FROM AUTHOR]

Published
2023
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2. Clinical outcomes of nivolumab plus ipilimumab in patients with metastatic non‐clear cell renal cell carcinoma: Real‐world data from a Japanese multicenter retrospective study

Author

Izumi, Keita, primary, Inoue, Masaharu, additional, Washino, Satoshi, additional, Shirotake, Suguru, additional, Kagawa, Makoto, additional, Takeshita, Hideki, additional, Miura, Yuji, additional, Hyodo, Yoji, additional, Oyama, Masafumi, additional, Kawakami, Satoru, additional, Miyagawa, Tomoaki, additional, Saito, Kazutaka, additional, and Kageyama, Yukio, additional

Published
2022
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22. Nomogram predicting testicular torsion in Japanese patients with acute scrotal pain using physical examination findings and environmental conditions: Development and prospective external validation.

Author

Takeshita, Hideki, Tachibana, Kojiro, Sugiyama, Hironori, Kagawa, Makoto, Yano, Akihiro, Okada, Yohei, Morozumi, Makoto, and Kawakami, Satoru

Subjects
SPERMATIC cord torsion, JAPANESE people, COLOR Doppler ultrasonography, PATIENTS' families, RECEIVER operating characteristic curves, NOMOGRAPHY (Mathematics)
Abstract

Objectives: To develop a prediction tool based on physical findings and environmental conditions without utilizing color Doppler ultrasonography to guide non‐urologists and patients' families in determining the testicular torsion possibility among patients with acute scrotal pain. Methods: Overall, 110 consecutive patients aged ≤30 years with acute scrotal pain at Saitama Medical Center between 2012 and 2014 were retrospectively evaluated. Physical examination results, including scrotal inspection, palpation and gait observation, and environmental conditions at pain onset (time range and ambient temperature) were collected. Multivariate analysis identified significant and independent risk factors for testicular torsion, and a nomogram predicting testicular torsion was constructed. The model underwent prospective validation in an independent set of 123 consecutive patients admitted with acute scrotal pain to our institution between 2015 and 2017. Results: Testicular torsion diagnosis rates were 27% (30/110) and 26% (32/123) in the training and validation cohorts, respectively. Logistic regression analysis showed four risk factors for developing testicular torsion: abnormal testicular position, walking difficulty, midnight to early morning onset and ambient temperature <15°C at pain onset. The constructed nomogram showed that the areas under the receiver operating characteristic curves were 0.92 and 0.84 for the training and validation cohorts, respectively. The calibration plot showed an acceptable fitness between the predicted probability and the observed rate of testicular torsion. Conclusions: A novel nomogram was developed solely based on physical findings and environmental conditions to predict testicular torsion in Japanese patients with acute scrotal pain. [ABSTRACT FROM AUTHOR]

Published
2022
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