1. Impact of fluorodeoxyglucose uptake on positron emission tomography/computed tomography on chemosensitivity and survival in patients with metastatic urothelial carcinoma
- Author
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Fumitaka Koga, Kazutaka Saito, Sho Uehara, Noboru Numao, Soichiro Yoshida, Minato Yokoyama, Ukihide Tateishi, Junji Yonese, Hiroshi Fukushima, Junichiro Ishioka, Masaki Kobayashi, Masaya Ito, Yasuhisa Fujii, Hajime Tanaka, Kazunori Kihara, and Yoh Matsuoka
- Subjects
Adult ,Male ,medicine.medical_specialty ,Urologic Neoplasms ,Multivariate analysis ,Metastatic Urothelial Carcinoma ,Urology ,medicine.medical_treatment ,030232 urology & nephrology ,Standardized uptake value ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Humans ,In patient ,Positron Emission Tomography-Computed Tomography ,Aged ,Neoplasm Staging ,Fluorodeoxyglucose ,Aged, 80 and over ,Chemotherapy ,Carcinoma, Transitional Cell ,business.industry ,Middle Aged ,Progression-Free Survival ,Drug Resistance, Neoplasm ,030220 oncology & carcinogenesis ,Cohort ,Female ,Radiopharmaceuticals ,business ,medicine.drug - Abstract
OBJECTIVES To evaluate the impact of fluorodeoxyglucose uptake on positron emission tomography/computed tomography on chemosensitivity and survival in patients with metastatic urothelial carcinoma. METHODS The present study assessed 51 metastatic urothelial carcinoma patients undergoing fluorodeoxyglucose positron emission tomography/computed tomography before first-line systemic chemotherapy. Fluorodeoxyglucose uptake in metastases was evaluated using the maximum standardized uptake value, which was measured for all eligible lesions, and the highest value among the maximum standardized uptake value measurements in each case was defined as the highest maximum standardized uptake value. The associations between the highest maximum standardized uptake value and objective response rate to chemotherapy, progression-free survival or cancer-specific survival were analyzed. For cancer-specific survival, the C-index was compared between multivariate models that incorporated predictors in the Bajorin model including the Karnofsky performance status and the presence of visceral metastasis, and the Apolo model additionally including hemoglobin and albumin levels, with/without the highest maximum standardized uptake value. RESULTS The median age was 69 years. The Karnofsky performance status was ≥80% for all patients. Visceral metastasis was observed in 12 patients (24%). The objective response rate, median progression-free survival and median cancer-specific survival were 61%, 9 and 26 months in the entire cohort, respectively. The higher highest maximum standardized uptake value was significantly associated with a lower objective response rate, shorter progression-free survival and shorter cancer-specific survival (P = 0.01
- Published
- 2018