1. The ophthalmic diagnosis and management of four siblings with Werner syndrome
- Author
-
C Lyons, E McElnea, F Kinsella, T McSwiney, and David Gallagher
- Subjects
Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,medicine.medical_specialty ,Werner Syndrome Helicase ,genetic structures ,medicine.medical_treatment ,WRN Protein ,Macular oedema ,Cataract Extraction ,Diagnostic Techniques, Ophthalmological ,Macular Edema ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,medicine ,Humans ,Werner syndrome ,business.industry ,Siblings ,nutritional and metabolic diseases ,Cataract surgery ,medicine.disease ,Dermatology ,eye diseases ,Ophthalmology ,Treatment Outcome ,Cystoid macular oedema ,030221 ophthalmology & optometry ,Female ,sense organs ,Werner Syndrome ,business ,030217 neurology & neurosurgery - Abstract
Werner syndrome is a rare autosomal recessive disorder caused by mutations in the Werner syndrome WRN gene, on chromosome 8. Those affected manifest early the features of ageing. Cataract surgery is prone to post-operative complications in those with Werner syndrome. The development of cystoid macular oedema (CMO) is likely multifactorial. Patients with WS have diabetes mellitus type 2 which can contribute to macular oedema. There is a deposition of abnormal WRN proteins in the macula which also predisposes to macular oedema. The trauma of cataract surgery appears to be the main stimulus for the development of CMO. CMO may, as a result, be difficult to manage in Werner syndrome patients. Further study is needed to elucidate the precise role of retinal WRN protein expression in the development of CMO in those with Werner syndrome. A tailored and more successful approach to the treatment of CMO in such patients may result.
- Published
- 2017