1. B cell development in mice.
- Author
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Kearney JF, Won WJ, Benedict C, Moratz C, Zimmer P, Oliver A, Martin F, and Shu F
- Subjects
- Animals, Antibody Diversity, Antigens, Differentiation, B-Lymphocyte metabolism, B-Lymphocyte Subsets cytology, B-Lymphocyte Subsets immunology, Bone Marrow embryology, Bone Marrow growth & development, Bone Marrow Cells, CD5 Antigens physiology, Cell Lineage, Cell Movement, Gene Rearrangement, B-Lymphocyte, Genes, Immunoglobulin, Immune System embryology, Immune System growth & development, Immune System immunology, Mice embryology, Mice genetics, Mice growth & development, Mice, Transgenic, Signal Transduction, Species Specificity, B-Lymphocytes cytology, Hematopoiesis, Mice immunology
- Abstract
The development and establishment of the B Cell Repertoire is the net result of both genetic and environmental forces. The primary event at the genetic level is Ig gene rearrangement resulting in numerous possible combination of genes which can be further modified by somatic events such as N segment addition and somatic mutation. Environmental forces in the form of self and exogenous Ags also shape the repertoire by positively or negatively selecting B cells according to the specificity of their Ig receptors. These are dynamic processes beginning with the earliest expression of immunoglobulins in fetal life and continuing throughout life. In this review we discuss the genetic and selective mechanisms responsible for differences in the early immune system compared to that of the adult.
- Published
- 1997
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