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Start Over Descriptor "IPSS" Journal international urology and nephrology
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4. Quality of life in patients with lower urinary tract symptoms associated with BPH: change over time in real-life practice according to treatment--the QUALIPROST study

Author

José L. Ruiz-Cerdá, José M Cózar-Olmo, Rafael Medina-López, José Manasanch, Federico Rodríguez-Rubio, Víctor Baena-González, Miguel Unda-Urzaiz, Joaquín Carballido-Rodríguez, Francisco J Brenes-Bermúdez, Darío García-Rojo, Antonio Alcaraz, [Alcaraz,A] Urology Department, Hosp. Clínic Univ., IDIBAPS, Barcelona, Spain . [Carballido-Rodríguez,J] Urology Department, Hosp. Univ. Puerta de Hierro, Majadahonda, Madrid, Spain. [Unda-Urzaiz,M] Urology Department, Hosp. Univ. Basurto, Bilbao, Spain. [Medina-López,R] Urology Department, Hosp. Univ. Virgen del Rocío, Sevilla, Spain. [Ruiz-Cerdá,JL] Urology Department, Hosp. Univ. La Fe, Valencia, Spain. [Rodríguez-Rubio,F] Department, Hosp. Univ. Puerto Real, Cádiz, Spain. [García-Rojo,D] Urology Department, Hosp. Univ. Parc Taulí Sabadell, Sabadell, Barcelona, Spain. [Brenes-Bermúdez,FJ] Llefià Primary Care Center, Badalona, Barcelona, Spain. [Cózar-Olmo,JM] Urology Department, Complejo Hospitalario Universitario de Granada, Granada, Spain. [Baena-González,V]Urology Department, Hosp. Univ. Carlos Haya, Málaga, Spain.[Manasanch,J] Pierre Fabre Ibérica S.A., Barcelona, Spain., and This study was funded by Pierre Fabre Ibérica

Subjects
Male, Fitoterapia, Inhibidores de 5-alfa-reductasa, Urología, medicine.medical_treatment, Calidad de vida, Health Care::Health Services Administration::Quality of Health Care::Outcome and Process Assessment (Health Care)::Outcome Assessment (Health Care)::Watchful Waiting [Medical Subject Headings], 030232 urology & nephrology, Espera vigilante, Prostatic Hyperplasia, Instituciones de atención ambulatoria, urologic and male genital diseases, Severity of Illness Index, Diseases::Male Urogenital Diseases::Genital Diseases, Male::Prostatic Diseases::Prostatic Hyperplasia [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, 0302 clinical medicine, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Adrenergic Agents::Adrenergic Antagonists::Adrenergic alpha-Antagonists [Medical Subject Headings], 5-alpha Reductase Inhibitors, Quality of life, Serenoa, Estudios prospectivos, Prostatism, Longitudinal Studies, Prospective Studies, Prospective cohort study, Extractos vegetales, Sulfonamides, Urology - Original Paper, IPSS, LUTS, Finasteride, Antagonistas adrenérgicos alfa, Middle Aged, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Complementary Therapies::Phytotherapy [Medical Subject Headings], Oxidorreductasas, Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Arecaceae::Serenoa [Medical Subject Headings], Nephrology, 030220 oncology & carcinogenesis, BPH, Drug Therapy, Combination, medicine.drug, Change over time, Tamsulosin, medicine.medical_specialty, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings], Urology, MEDLINE, Check Tags::Male [Medical Subject Headings], Hiperplasia prostática, Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Urological Manifestations::Lower Urinary Tract Symptoms [Medical Subject Headings], 03 medical and health sciences, Quality of life (healthcare), Text mining, Lower Urinary Tract Symptoms, Lower urinary tract symptoms, Disciplines and Occupations::Social Sciences::Quality of Life [Medical Subject Headings], Internal medicine, Real-life practice, medicine, In real life, Humans, In patient, Síntomas del sistema urinario inferior, Chemicals and Drugs::Complex Mixtures::Biological Agents::Plant Preparations::Plant Extracts [Medical Subject Headings], Watchful Waiting, BII, Adrenergic alpha-Antagonists, Aged, Gynecology, business.industry, Plant Extracts, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Enzyme Inhibitors::5-alpha Reductase Inhibitors [Medical Subject Headings], Dutasteride, medicine.disease, Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Ambulatory Care Facilities [Medical Subject Headings], Disciplines and Occupations::Health Occupations::Medicine::Specialties, Surgical::Urology [Medical Subject Headings], chemistry, Quality of Life, sense organs, business, Watchful waiting, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases [Medical Subject Headings], Phytotherapy
Abstract

Journal Article; PURPOSE To evaluate change in quality of life (QoL) and symptoms in patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) in conditions of current clinical practice. METHODS Prospective, longitudinal, multicenter open-label study was carried out in urology outpatient clinics. Patients were ≥40 years of age with an International Prostate Symptom Score (IPSS) score ≥8. QoL and symptoms were measured at baseline and 6 months using the Benign Prostatic Hyperplasia Impact Index (BII) and the IPSS. RESULTS 1713 patients were included for analysis. Mean (SD) IPSS and BII scores at baseline were 16.8 (5.4) and 6.8 (2.6), respectively. 8.9 % (n = 153) of study participants did not receive treatment (watchful waiting, WW), 70.3 % (n = 1204) were prescribed monotherapy (alpha-adrenergic blockers [AB]; phytotherapy [PT, of which 95.2 % was the hexanic extract of Serenoa repens, HESr]; or 5-alpha-reductase inhibitors [5ARI]), and 20.8 % (n = 356) received combined treatment (AB + 5ARI; AB + HESr; others). At 6 months, improvements in QoL were similar across the different medical treatment (MT) groups, both for monotherapy (AB: mean improvement [SD] of 2.4 points [2.4]; PT: 1.9 [2.4]; 5ARI: 2.5 [2.3]) and combined therapy (AB + 5ARI: 3.1 [2.9]; AB + PT: 3.1 [2.5]). There were no clinically significant differences between MT groups and all showed significant improvement over WW (p

Published
2015

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