1. A meta-analysis examining the impact of intrawound treatment on reducing deep surgical site infections during instrumented spine surgery.
- Author
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Zhou L and Xing S
- Subjects
- Humans, Povidone-Iodine therapeutic use, Surgical Wound Infection prevention & control, Surgical Wound Infection drug therapy, Antibiotic Prophylaxis methods, Retrospective Studies, Vancomycin therapeutic use, Anti-Bacterial Agents therapeutic use
- Abstract
The purpose of the meta-analysis was to evaluate and compare the effect of intrawound management on decreasing deep surgical site infections (SSIs) in instrumented spinal surgery (SS). The results of this meta-analysis were analysed, and the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) were calculated using dichotomous or contentious random or fixed effect models. For the current meta-analysis, 29 examinations spanning from 2006 to 2022 were included, encompassing 11 181 people who had instrumented SS. Intrawound management had a significantly lower deep SSI when using vancomycin (OR, 0.34; 95% CI, 0.25-0.44, p < 0.001) and povidone-iodine as intrawound management (OR, 0.24; 95% CI, 0.13-0.42, p < 0.001) compared to control in instrumented SS subjects. The data that was looked at showed that using vancomycin and povidone-iodine as intrawound management had a much lower deep SSI than using a control group of instrumented SS subjects. However, given that some studies included a small number of subjects, attention should be given to their values., (© 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.)
- Published
- 2024
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