1. Structural comparison of the external glycoproteins of human and simian immunodeficiency virus
- Author
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Wolfgang Lüke, Jens Rietschel, Gerhard Hunsmann, Raimund Sprenger, Doris Schreiner, and Claudia Fendrich
- Subjects
viruses ,animal diseases ,Retroviridae Proteins ,Simian Acquired Immunodeficiency Syndrome ,Simian ,HIV Envelope Protein gp120 ,medicine.disease_cause ,Genome ,Peptide Mapping ,Virus ,Viral Envelope Proteins ,Virology ,Sequence Homology, Nucleic Acid ,medicine ,Centrifugation, Density Gradient ,Animals ,Amino Acid Sequence ,Peptide sequence ,Immunodeficiency ,Genetics ,chemistry.chemical_classification ,biology ,virus diseases ,Simian immunodeficiency virus ,medicine.disease ,biology.organism_classification ,Infectious Diseases ,chemistry ,HIV-2 ,HIV-1 ,Simian Immunodeficiency Virus ,African Green Monkey ,Glycoprotein - Abstract
The structural variability of the external glycoproteins of primate immunodeficiency viruses, has, so far, been investigated exclusively by sequence comparison of the respective proviral genomes. We have examined the structural relationship amount the external glycoproteins from three specific human immunodeficiency viruses (HIF-1, HIV-2), three specific simian immunodeficiency viruses from macaques (SIVmac) and three specific SIV from African green monkeys (SIVagm) by peptide mapping. Differences among glycoproteins were most pronounced between HIV-1 and SIVmac, as well as HIV-2. Two specific glycoproteins from independent SIVagm isolates were closely related to HIV-1, whereas the glycoprotein from a third SIVagm isolate was more similar to those of SIVmac and HIV-2. Our analysis reflects the classification of primate immunodeficiency viruses into three groups, the HIV-2 and SIVmac viruses, the green monkey isolates and HIV-1.
- Published
- 1991