1. JC Virus Replication at the First Symptoms of Multiple Sclerosis: A Case Report.
- Author
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Delbue S, Tadeo CS, Elia F, and Ferrante P
- Subjects
- Blood virology, Cerebrospinal Fluid virology, Female, Humans, Polyomavirus Infections virology, Tumor Virus Infections virology, Urine virology, JC Virus isolation & purification, Multiple Sclerosis etiology, Polyomavirus Infections complications, Tumor Virus Infections complications
- Abstract
Multiple sclerosis (MS) is an autoimmune, demyelinating disorder of unknown etiology, in which viruses have been suggested as etiological/triggering agents. The attention to the association between viruses and MS has been rekindled by the development of progressive multifocal leukoencephalopathy in natalizumab-treated MS patients. Here we report the case of a woman with JC virus (JCV) replication in the cerebrospinal fluid, blood and urine collected at the first symptoms of MS and during several follow-up visits. This observation shows that JCV can be associated with MS without a relation with natalizumab treatment, although the triggering role of JCV in some cases of MS will require further studies., (© 2015 S. Karger AG, Basel.)
- Published
- 2015
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