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Start Over Author "Arifin N" Journal iop conference series: materials science and engineering
7 results on '"Arifin N"'

6. Identification of microRNAs targeting NAT1 and NAT2 gene transcripts in prostate cancer patients observed in different races

Author

M Zainul Arifin N, David Agustriawan, Arli Aditya Parikesit, Rizky Nurdiansyah, and Kevin Nathanael Ramanto

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, MiRTarBase, In silico, Small sample, Biology, medicine.disease, 03 medical and health sciences, Prostate cancer, 030104 developmental biology, 0302 clinical medicine, Nat2 gene, 030220 oncology & carcinogenesis, Internal medicine, microRNA, medicine, Lung cancer, Gene
Abstract

Prostate cancer has the second highest death rate second only to lung cancer. Mutation in a single gene does not cause prostate cancer. Instead, many different genes are responsible, including NAT1 and NAT2 gene. By finding microRNAs that can suppress NAT1 and NAT2 gene, a novel prostate cancer treatment can be developed. Prostate cancer is also more commonly found in African-American than White-American. Therefore, this in silico study aimed to find several microRNAs targeting NAT1 and NAT2 gene observed in black, white, and other racial groups. 100 white patients, 100 races not reported patients, 11 black patients, and 638 combined races patient’s expression data were collected with TCGA-Assembler in R from The Cancer Genomic Atlas (TCGA). Next, Spearman correlation analysis was performed in R to find microRNAs that are negatively correlated with NAT1 and NAT2 gene. MicroRNAs were validated with miRTarBase and RNAhybrid. Only microRNAs which are located in combined patients and found in at least another race group is considered, i.e., hsa-mir-103a-1, hsa-mir-183, hsa-mir-32, and hsa-mir-96. Race-specific microRNA cannot be determined due to small sample size in black race group. Further study is needed to confirm the interaction between listed microRNAs with NAT1 and NAT2 gene expressions.

Published
2019
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7. The influence of composition and final pyrolysis temperature variations on global kinetics of combustion of segregated municipal solid waste

Author

Himawanto, D A and Arifin, N A

Abstract

The combustion of segregated municipal solid waste (MSW) and the resulted char from the pyrolysis process were investigated in this research. The segregated MSW that was collected and used can be divided into organic and inorganic waste materials. The organic materials were bamboo and banana leaves and the inorganic materials were Styrofoam and snack wrappings. The composition ratio of the waste was based on the percentage of weight of each sample. The thermal behaviour of the segregated MSW was investigated by thermo gravimetric analysis. For the pyrolysis process the prepared samples of 200gram were heated from ambient temperature until a variance of final pyrolysis temperature of 550degC, 650degC and 750degC at a constant heating rate of 25degC/min. It was found that the highest activation energy of the raw materials is achieved from sample CC1 (Char with 100% inorganic materials). The activation energy of the raw materials is relatively lower than that of the char. The higher the final pyrolysis temperature, the lower the calorific value of char. The calorific value gradually increases with the amount of inorganic materials.

Published
2017

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