1. Expression of Galectin-9-related immune checkpoint receptors in B-cell acute lymphoblastic leukemia
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Armin Akbar, Hossein asgariyan-Omran, Reza Valadan, Mohammad-Mehdi Dindarloo, Ahmad Najafi, Amir Kahrizi, Arash Poursheikhani, Hossein Karami, Mohammad Naderi, Shayan Sabeti, and Mohsen Tehrani
- Subjects
acute lymphoblastic - leukemia ,gelectin-9 ,havcr2 ,immune checkpoint - receptor ,t-cell exhaustion ,tim-3 ,vista ,Medicine - Abstract
Objective(s): Exhausted CD8+ T-cells over-express immune checkpoint receptors (ICRs), which interact with their ligands on malignant cells. However, some ICRs have been reported to be expressed on both T-cells and tumor cells, including V-domain immunoglobulin suppressor of T cell activation (VISTA), Galectin-9, and T-cell immunoglobulin mucin-3 (TIM-3). We aimed to evaluate the mRNA expression of VISTA, Galectin-9, and TIM-3 on CD8+ T-cells and leukemic cells in B-cell acute lymphoblastic leukemia (B-ALL).Materials and Methods: Samples were obtained from 26 untreated B-ALL patients and 25 control subjects. CD8+ T-cells were isolated using Magnetic Activated Cell Sorting (MACS). Relative gene expression was then evaluated by qRT-PCR with specific primers for VISTA, Galectin-9, and TIM-3. Also, the mRNA expression profile and clinical data of 154 B-ALL patients were obtained from the TARGET.Results: mRNA expression of Galectin-9 on CD8+ T-cells in B-ALL patients was significantly lower than those in the control group (P=0.043), while VISTA expression was not significantly different between the two study groups (P=0.259). Besides, TIM-3 expression was significantly higher in B-ALL patients than in the control group (P
- Published
- 2023
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