1. Suboptimal lipid management before and after ischaemic stroke and TIA-the North Dublin Population Stroke Study
- Author
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David Williams, Orla Sheehan, Aine Merwick, Elizabeth Callaly, Sean M. Murphy, Niamh Hannon, Chantelle Ní Chróinín, Lisa A. Kelly, Lorraine Kyne, Peter J. Kelly, Danielle Ní Chróinín, Eamon Dolan, Michael Marnane, Layan Akijian, Joseph Duggan, and Gillian Horgan
- Subjects
Male ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Population ,030204 cardiovascular system & hematology ,Cohort Studies ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Ischemia ,Diabetes mellitus ,Internal medicine ,Ischaemic stroke ,medicine ,Humans ,cardiovascular diseases ,Prospective Studies ,education ,Stroke ,Aged ,education.field_of_study ,Cholesterol ,business.industry ,Atrial fibrillation ,General Medicine ,Odds ratio ,Cholesterol, LDL ,medicine.disease ,Lipids ,chemistry ,Ischemic Attack, Transient ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,Ireland ,030217 neurology & neurosurgery - Abstract
Few population-based studies have assessed lipid adherence to international guidelines for primary and secondary prevention in stroke/transient ischaemic attack (TIA) patients. This study aims to evaluate adherence to lipid-lowering therapy (LLT) guidelines amongst patients with ischaemic stroke/TIA. Using hot and cold pursuit methods from multiple hospital/community sources, all stroke and TIA cases in North Dublin City were prospectively ascertained over a 1-year period. Adherence to National Cholesterol Education Programme (NCEP) III guidelines, before and after index ischaemic stroke/TIA, was assessed. Amongst 616 patients (428 ischaemic stroke, 188 TIA), total cholesterol was measured following the qualifying event in 76.5% (471/616) and low-density lipoprotein (LDL) in 60.1% (370/616). At initial stroke/TIA presentation, 54.1% (200/370) met NCEP III LDL goals. Compliance was associated with prior stroke (odds ratio [OR] 2.19, p = 0.02), diabetes (OR 1.91, p = 0.04), hypertension (OR 1.57, p = 0.03), atrial fibrillation (OR 1.78, p = 0.01), pre-event LLT (OR 2.85, p
- Published
- 2017