19 results on '"Kieran C. Murphy"'
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2. Impact of initial COVID-19 restrictions on psychiatry presentations to the emergency department of a large academic teaching hospital
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Mary Cannon, Julia O’Leary, David Cotter, Joseph McAndrew, Siobhan MacHale, Helen Barry, and Kieran C. Murphy
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medicine.medical_specialty ,emergency department ,History and Philosophy of Science ,Humans ,Medicine ,Hospitals, Teaching ,Psychiatry ,Suicidal ideation ,Applied Psychology ,Retrospective Studies ,Original Research ,SARS-CoV-2 ,business.industry ,COVID-19 ,Retrospective cohort study ,Emergency department ,Mental illness ,medicine.disease ,Mental health ,Test (assessment) ,Coronavirus ,Psychiatry and Mental health ,Distress ,Anxiety ,medicine.symptom ,Emergency Service, Hospital ,business ,Ireland ,mental health - Abstract
Objectives:To determine if the initial COVID-19 societal restrictions, introduced in Ireland in March 2020, impacted on the number and nature of psychiatry presentations to the emergency department (ED) of a large academic teaching hospital.Methods:We examined anonymised clinical data of psychiatry presentations to the ED during the initial 8-week period of COVID-19 restrictions. Data from corresponding 8-week periods in 2018 and 2019 were also extracted for comparison.Results:Psychiatry presentations to ED reduced by 21% during the COVID-19 restrictions, from 24/week to 19/week when compared with corresponding periods in 2018/2019 (Poisson’s Rate Test estimate of difference −5.2/week, 95% CI 1.3–9.1, p = 0.012). Numbers attending for out-of-hours assessment remained unchanged (81 v. 80), but numbers seeking assessment during normal hours decreased (71 v. 114). We observed increased presentations from the p = 0.002). We recorded an increase in anxiety disorders during the initial COVID-19 restrictions (31 v. 23), and a reduction in alcohol disorders (28 v. 52). The proportion of presentations with suicidal ideation (SI) or self-harm as factors remained unchanged.Conclusions:Rates of emergency presentation with mental illness reduced during the initial COVID-19 restrictions. This may represent an unmet burden of mental health needs. Younger people may be experiencing greater distress and mental illness during the current crisis. More people sought help for anxiety disorders during the COVID-19 restrictions compared with corresponding data from 2018 and 2019.
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- 2020
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3. Undergraduate learning in psychiatry: can we prepare our future medical graduates better?
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Kieran C. Murphy, Linda O'Rourke, and Vincent Russell
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medicine.medical_specialty ,education ,Context (language use) ,Primary care ,General medical services ,Secondary care ,03 medical and health sciences ,0302 clinical medicine ,History and Philosophy of Science ,Irish ,medicine ,Humans ,030212 general & internal medicine ,Sociology ,Students ,Psychiatry ,Curriculum ,Schools, Medical ,Applied Psychology ,Mental health ,language.human_language ,030227 psychiatry ,Psychiatry and Mental health ,language ,Mental health care ,Ireland - Abstract
Irish medical schools attract an increasingly diverse student population and produce graduates who will practise in many parts of the world. There are particular implications in this for the planning and delivery of the undergraduate psychiatry curriculum. In all countries, mental health services struggle for equitable resourcing, and mental health care within general medical services remains relatively neglected. The traditional undergraduate psychiatry offering has been justifiably criticised for being excessively oriented towards secondary care when the vast majority of medical graduates will pursue careers in primary care or in specialties other than psychiatry. Recently published articles in the Irish Journal of Psychological Medicine address the current challenges and opportunities in providing an undergraduate experience that better prepares students for the mental health aspects of medical practice in a global context. We summarise and discuss these contributions and the recent Royal College of Psychiatrists publication Choose Psychiatry: Guidance for Medical Schools.
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- 2020
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4. One year of psychiatric presentations to a hospital emergency department during COVID-19
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Yvonne Hartnett, Khadija Alshurafa, Joseph McAndrew, Darren Daly, Mohamed Alsaffar, David Cotter, Mary Cannon, Siobhan MacHale, Kieran C. Murphy, and Helen Barry
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Psychiatry and Mental health ,History and Philosophy of Science ,Applied Psychology - Abstract
Objectives: To examine the impact of the first full year of the COVID-19 pandemic and its associated restrictions on the volume and nature of psychiatric presentations to an emergency department (ED) in a large academic hospital. Methods: Anonymised clinical data on psychiatric presentations to the ED were collected for the 52-week period from the start of the COVID-19 pandemic and compared with corresponding 1 year periods in 2019 and 2018. Results: There was a significant increase in psychiatric presentations overall to the ED during the first year of the COVID-19 pandemic compared to previous years, in contrast to a reduction in total presentations for all other specialties. There was a marked increase in psychiatric presentations of those below 18 years, and in the 30–39 years and 40–49 years age groups, but a decrease in the 18–29 years group. There was a significant increase in anxiety disorder presentations but a decrease in alcohol related presentations. There was no significant change observed in the rates of presentations for self-harm or suicidal ideation. Conclusions: Psychiatric presentations to the ED have increased during the first year of the COVID-19 pandemic in contrast to a decrease in presentations for other medical specialties, with this increase being driven by out-of-hours presentations. The fourfold increase in presentations of young people below the age of 18 years to the ED with mental health difficulties is an important finding and suggests a disproportionate burden of psychological strain placed on this group during the pandemic.
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- 2022
5. Establishing and evaluating a Balint group for fourth-year medical students at an Irish University
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Gearoid Fitzgerald, Sorcha McManus, Yvonne Hartnett, David Killeen, and Kieran C. Murphy
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Students, Medical ,Balint group ,media_common.quotation_subject ,Empathy ,03 medical and health sciences ,0302 clinical medicine ,History and Philosophy of Science ,Irish ,Intervention (counseling) ,Humans ,Prospective Studies ,030212 general & internal medicine ,Schools, Medical ,Applied Psychology ,media_common ,Psychiatry ,Physician-Patient Relations ,Medical education ,Significant difference ,Resilience, Psychological ,language.human_language ,030227 psychiatry ,Psychiatry and Mental health ,Scale (social sciences) ,language ,Resilience scale ,Psychological resilience ,Psychology - Abstract
ObjectiveThe study was designed to establish and evaluate the impact of a 6-week Balint group on empathy and resilience in fourth-year medical students during their psychiatry rotation.MethodologyThis prospective study used the Jefferson Scale of Empathy – Student Version and the Brief Resilience Scale before and after 6-week Balint groups. Participating students also completed a qualitative assessment of their experience.ResultsStudents who participated were enthusiastic regarding the value of Balint groups in promoting self-reflection and gaining insight into self- and patient-care dynamics. There was a significant difference in empathy scores pre- and post-Balint intervention. There was no significant difference in resilience scores.ConclusionThe establishment of a 6-week Balint group for fourth-year medical students was successful in increasing empathy. Students reported a positive view of Balint and its beneficial role in this study group.
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- 2019
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6. Psychiatric and psychosocial morbidity 1 year after epilepsy surgery
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Helen Barry, N. Quigley, Maurice Clancy, Mary Clarke, S. Patel, David Cotter, Norman Delanty, Mary Cannon, and Kieran C. Murphy
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0303 health sciences ,education.field_of_study ,Psychosis ,medicine.medical_specialty ,business.industry ,Population ,Hospital Anxiety and Depression Scale ,medicine.disease ,03 medical and health sciences ,Psychiatry and Mental health ,Epilepsy ,0302 clinical medicine ,History and Philosophy of Science ,Quality of life ,medicine ,Epilepsy surgery ,education ,business ,Psychiatry ,Psychosocial ,030217 neurology & neurosurgery ,Applied Psychology ,030304 developmental biology ,Psychopathology - Abstract
Objectives: There is a high rate of psychiatric comorbidity in patients with epilepsy. However, the impact of surgical treatment of refractory epilepsy on psychopathology remains under investigation. We aimed to examine the impact of epilepsy surgery on psychopathology and quality of life at 1-year post-surgery in a population of patients with epilepsy refractory to medication. Methods: This study initially assessed 48 patients with refractory epilepsy using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), the Hospital Anxiety and Depression Scale (HADS) and the Quality of Life in Epilepsy Inventory 89 (QOLIE-89) on admission to an Epilepsy Monitoring Unit (EMU) as part of their pre-surgical assessment. These patients were again assessed using the SCID-I, QOLIE-89 and HADS at 1-year follow-up post-surgery. Results: There was a significant reduction in psychopathology, particularly psychosis, following surgery at 1-year follow-up (p < 0.021). There were no new cases of de novo psychosis and surgery was also associated with a significant improvement in the quality of life scores (p < 0.001). Conclusions: This study demonstrates the impact of epilepsy surgery on psychopathology and quality of life in a patient population with refractory surgery. The presence of a psychiatric illness should not be a barrier to access surgical treatment.
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- 2020
7. A psychoeducational intervention increases use of a delirium protocol by Neurologists and Neurosurgeons in patients with brain disorders
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C. Carey, Sonn Patel, Kieran C. Murphy, and David Cotter
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medicine.medical_specialty ,Referral ,business.industry ,Psychoeducational intervention ,Audit ,030204 cardiovascular system & hematology ,Neuropsychiatry ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,Mood ,History and Philosophy of Science ,Intervention (counseling) ,Emergency medicine ,medicine ,Delirium ,030212 general & internal medicine ,Medical diagnosis ,medicine.symptom ,business ,Applied Psychology - Abstract
Objectives: Over 50% of inpatients with neurological disorders may present with a co-morbid psychiatric illness. Delirium has a reported point prevalence of 20% in hospital inpatients and is frequently undetected. We aimed to (1) examine inpatient referrals to a Liaison Neuropsychiatry service and (2) review the diagnosis and management of delirium before and after an educational intervention. Methods: An initial 6-month audit of referrals to the inpatient Liaison Neuropsychiatry service was conducted in 2018. We then undertook a psychoeducational intervention to raise awareness of the diagnosis and management of delirium. We conducted a re-audit of referrals to the service in 2019. Results: On initial audit, of 84 referrals, the most common referral was for mood (38%; n = 32). Just 4% (n = 3) had a specific delirium query. Following assessment by Neuropsychiatry, organic disorders (43%; n = 32), including delirium (33%; n = 25), were the most common diagnoses. On re-audit, of 86 referrals, mood assessment remained the most common reason for referral (38%; n = 33) and 2% (n = 2) were referred for possible delirium. Organic disorders remained the most common diagnoses (53%; n = 45) including delirium (38%; n = 32). We found a significant increase in the use of the delirium protocol from 12% (n = 3) on initial audit to 47% (n = 15); p < 0.01 on re-audit despite no increase in the number of specific delirium queries. Conclusions: A psychoeducational intervention improves the management of delirium by Neurologists and Neurosurgeons in patients with brain disorders.
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- 2020
8. A comparison of undergraduate teaching of psychiatry across medical schools in the Republic of Ireland
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E. B. Sweeney, Rebecca Murphy, A. Campbell, Brian Hallahan, Allys Guerandel, Michael Gill, David Cotter, Fintan Byrne, David Meagher, Colm McDonald, Kieran C. Murphy, and Linda O'Rourke
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medicine.medical_specialty ,Objective structured clinical examination ,assessment ,education ,Physical examination ,small group teaching ,medical school ,The Republic ,Continuous assessment ,03 medical and health sciences ,0302 clinical medicine ,History and Philosophy of Science ,Forensic psychiatry ,medicine ,Humans ,Narrative ,030212 general & internal medicine ,Psychiatry ,Applied Psychology ,Schools, Medical ,Medical education ,medicine.diagnostic_test ,business.industry ,Medical school ,psychiatry ,teaching ,030227 psychiatry ,Psychiatry and Mental health ,Family medicine ,Curriculum ,Large group ,business ,Ireland ,Education, Medical, Undergraduate - Abstract
ObjectivesTo examine the delivery and assessment of psychiatry at undergraduate level in the six medical schools in the Republic of Ireland offering a medical degree programme.MethodsA narrative description of the delivery and assessment of psychiatry at undergraduate level by collaborative senior faculty members from all six universities in Ireland.ResultsPsychiatry is integrated to varying degrees across all medical schools. Clinical experience in general adult psychiatry and sub-specialities is provided by each medical school; however, the duration of clinical attachment varies, and the provision of some sub-specialities (i.e. forensic psychiatry) is dependent on locally available resources. Five medical schools provide ‘live’ large group teaching sessions (lectures), and all medical schools provide an array of small group teaching sessions. Continuous assessment encompasses 10–35% of the total assessment marks, depending on the medical school. Only one medical school does not provide a clinical examination in the form of an Objective Structured Clinical Examination with viva examinations occurring at three medical schools.ConclusionsMany similarities exist in relation to the delivery of psychiatry at undergraduate level in Ireland. Significant variability exists in relation to assessment with differences in continuous assessment, written and clinical exams and the use of vivas noted. The use of e-learning platforms has increased significantly in recent years, with their role envisaged to include cross-disciplinary teaching sessions and analysis of examinations and individual components within examinations which will help refine future examinations and enable greater sharing of resources between medical schools.
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- 2020
9. Implication of rates of referral to a specialised inpatient neuropsychiatry team
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Pauline Devitt, Finian M O'Brien, Ciaran Corcoran, and Kieran C. Murphy
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medicine.medical_specialty ,Referral ,business.industry ,Psychiatric assessment ,Neuropsychiatry ,Mental illness ,medicine.disease ,Mental health ,Psychiatry and Mental health ,History and Philosophy of Science ,Emergency medicine ,Epidemiology ,medicine ,Outpatient clinic ,Anxiety ,medicine.symptom ,business ,Applied Psychology - Abstract
Objectives: This study examined and compared the number and pattern of referrals from neurosurgery and neurology specialist services to the inpatient liaison neuropsychiatry service in the years 2002 and 2005. We estimated the prevalence of psychiatric illness and evaluated the results of subsequent psychiatric assessment and follow-up of all patients reviewed by the neuropsychiatry service.Methods: The medical notes of those patients referred to the neuropsychiatry team were retrospectively examined to obtain appropriate information on assessment and management of these cases.Results: There were 544 referrals over the two years selected for study. Rates of referral to the inpatient neuropsychiatry service increased overall by 35% between 2002 and 2005. Overall, referrals from neurology comprised 85%, neurosurgery 15%. Patients with epilepsy comprised the majority of referrals (36%). A total of 378 (73%) had an acute psychiatric disorder and this group had a significantly higher rate (p = 0.01) of past psychiatric disorder (40%) than that in those with no acute mental illness (33%). Depressive episode was the most frequent acute psychiatric diagnosis (38%), followed by anxiety and organic psychiatric disorder (both 15%). Overall, 21% of patients diagnosed with acute mental illness were referred on discharge to the neuropsychiatry outpatient clinic for specialist follow up and the remainder followed-up by either local mental health teams or their GP.Conclusions: These findings provide clear evidence that further resources should be allocated to expanding neuropsychiatry mental health services to improve detection and management of mental illness in this vulnerable patient group.
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- 2018
10. Psychogenic non-epileptic seizures in an Irish tertiary referral centre for epilepsy
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Norman Delanty, Finian M O'Brien, Kieran C. Murphy, and Catherine Dineen
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medicine.medical_specialty ,education.field_of_study ,genetic structures ,Referral ,business.industry ,Medical record ,Population ,Neuropsychology ,medicine.disease ,Psychiatry and Mental health ,Epilepsy ,History and Philosophy of Science ,Psychogenic non-epileptic seizures ,medicine ,Psychogenic disease ,Psychiatry ,education ,business ,Conversion disorder ,Applied Psychology - Abstract
Objectives: To examine the prevalence, psychiatric co-morbidity and management of psychogenic non-epileptic seizures (PNES) in patients admitted to a tertiary referral Epilepsy Monitoring Unit (EMU).Methods: Medical records of patients admitted to the EMU between 2003 and 2005 were examined and data from neurological, neuropsychiatric and neuropsychological assessments were analysed.Results: Over a three year period 224 patients were referred to the EMU and 44 (20%) were diagnosed with psychogenic non-epileptic seizures (PNES). A total of 13 people (6%) were diagnosed with both PNES and epilepsy. Of those diagnosed with PNES 34 (75%) were referred to psychology services for cognitive behavioural therapy (CBT) and 26 (58%) were followed-up by psychiatry services.Conclusions: The prevalence rates for PNES and co-existing PNES and epilepsy are consistent with previous reports. Rates of psychiatric co-morbidity were less than would be expected in this clinical population. Clear evidence-based guidelines to manage people with PNES are required.
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- 2018
11. Catatonia - case report and review
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Joan T. Moroney, Kieran C. Murphy, Finian M O'Brien, and Declan Lyons
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Pediatrics ,medicine.medical_specialty ,Activities of daily living ,business.industry ,Catatonia ,medicine.medical_treatment ,MEDLINE ,Psychotropic medication ,medicine.disease ,Psychiatry and Mental health ,Regimen ,Electroconvulsive therapy ,History and Philosophy of Science ,medicine ,Psychiatric hospital ,General hospital ,business ,Psychiatry ,Applied Psychology - Abstract
Catatonia is a neuro-psychiatric disorder that can occur in medical, psychiatric and drug-induced conditions but is often unrecognised. A 64 year-old woman was admitted to hospital for assessment of a significant deterioration in her ability to communicate and function normally so that she had become completely dependent on others for all activities of daily living for nearly three years. Outpatient medical and psychiatric assessments failed to clarify diagnosis. On admission to a general hospital, the neurology team initially believed she had a Parkinson's-like syndrome but after further investigation and comprehensive multidisciplinary assessment, including neuro-psychiatric review, she was diagnosed with catatonia. She was subsequently admitted to a psychiatric hospital where she received electro-convulsive therapy and changes to her psychotropic medication regimen. She responded well to treatment and within a short period of time was able to function independently again.
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- 2018
12. Non-graduate and graduate entry medical students attitudes to psychiatry
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Frederick Sundram, M Boohan, D Mullins, N Rizvi, Kieran C. Murphy, SM Pillay, and T Grant
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Attractiveness ,medicine.medical_specialty ,Medical education ,business.industry ,education ,Graduate entry ,Specialty ,Future career ,Psychiatry and Mental health ,History and Philosophy of Science ,General practice ,Medicine ,Positive attitude ,business ,Psychiatry ,Applied Psychology ,Career choice - Abstract
ObjectiveGraduate entry medical students’ views of psychiatry may differ from those of school leavers. This study hypothesised that (i) exposure to a psychiatry attachment is associated with a positive change in attitudes towards psychiatry in both graduate entry and non-graduate entry students, (ii) graduate entry students exhibit a more positive attitude to psychiatry compared to non-graduate entry students and (iii) graduate entry students are more interested in a career in psychiatry than non-graduate entry students.MethodsIn this study 247 medical students (118 females and 129 males) completing their psychiatry rotation were invited to complete questionnaires examining career choice, attitudes to psychiatry and career attractiveness for a range of specialties including surgery, medicine, general practice and psychiatry before and after their psychiatry attachment. Questionnaires were distributed prior to commencement of their attachment and redistributed on the final day of the attachment.ResultsOf the 165 participants in the study, 75 students entered medicine via the traditional route (without a primary degree), 49 entered via the graduate entry programme and 41 had a primary degree. Overall, medical students displayed positive attitudes towards psychiatry. However, while there was an improvement in attitudes towards psychiatry and the career attractiveness of psychiatry on completion of the rotation, no differences were found between graduate and non-graduate entry students. Psychiatry and general practice had lower ratings for career attractiveness than other specialities. No significant changes were found in the first and second choice of specialty.ConclusionOur results show that improvements in attitude and career attractiveness do not necessarily correlate with increased choice of psychiatry as a specialty. Graduate entry has been considered a possible opportunity for increasing recruitment in psychiatry but our results suggest that this may not be the case. Follow-up studies are required to determine whether career attractiveness correlates with future career choice.
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- 2018
13. The digital age: is this the future of medical education? A cross-sectional study to assess medical students' opinions about e-learning in psychiatry undergraduate medical education
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F. Jabbar, N. Fenlon, D Mullins, and Kieran C. Murphy
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Response rate (survey) ,Medical education ,medicine.medical_specialty ,Academic year ,business.industry ,Cross-sectional study ,E-learning (theory) ,Preference ,Learning styles ,Psychiatry and Mental health ,History and Philosophy of Science ,Virtual learning environment ,Medicine ,business ,Psychiatry ,Applied Psychology ,Pace - Abstract
ObjectivesThe main objectives were to assess medical students’ opinions about e-learning in psychiatry undergraduate medical education, and to investigate a possible relationship between learning styles and preferences for learning modalities.MethodDuring the academic year 2009/2010, all 231 senior Royal College of Surgeons in Ireland (RCSI) medical students in their penultimate year of study were invited to answer a questionnaire that was posted online on Moodle, the RCSI virtual learning environment.ResultsIn all, 186 students responded to the questionnaire, a response rate of 80%. Significantly more students stated a preference for live psychiatry tutorials over e-learning lectures. Students considered flexible learning, having the option of viewing material again and the ability to learn at one’s own pace with e-learning lectures, to be more valuable than having faster and easier information retrieval.ConclusionStudents prefer traditional in-class studying, even when they are offered a rich e-learning environment. Understanding students’ learning styles has been identified as an important element for e-learning development, delivery and instruction, which can lead to improved student performance.
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- 2018
14. Increased use of security personnel in Irish psychiatric hospitals: 2008-2012
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Stephen Shannon, Patrick J. Devitt, and Kieran C. Murphy
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medicine.medical_specialty ,business.industry ,Best practice ,Legislation ,Military psychiatry ,Mental health ,language.human_language ,Unit (housing) ,Psychiatry and Mental health ,History and Philosophy of Science ,Irish ,Work (electrical) ,Content analysis ,medicine ,language ,Psychiatry ,business ,Applied Psychology - Abstract
ObjectivesLittle is known about the involvement of security personnel in Irish psychiatric care. Content analysis of inspection reports is a feasible way to investigate this under-researched topic. We aimed to (i) Describe the number of approved centres per year in which we observed comments about the presence of security personnel in published reports of inspections conducted from 2008 to 2012 (ii) Report the main themes of all text relating to security personnel published in these inspection reports.MethodWe conducted a content analysis of all 349 inspection reports published between 2008 and 2012.ResultsThe number of approved centres in which security personnel were noted increased from 3% to 8% between the years 2008 and 2012. This increase was not statistically significant when the same unique centres were compared between years (p=0.684). Employment details such as contracted employment relationship, location relative to the approved centre and hours of work appeared inconsistent across centres. Role functions of security personnel differed across centres and ranged from monitoring the entrance of a unit to observing, restraining and secluding patients. Contrasting perceptions of suitability were evident in the inspection reports. The extent to which the training needs of security personnel were met was unclear from the reports.ConclusionsActivity of security personnel in psychiatric hospitals may not be role appropriate, compliant with legislation or conducive to treatment. Best practice guidelines should be developed in consultation with multiple stakeholders.
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- 2018
15. Autistic spectrum disorders
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Brian Hallahan and Kieran C. Murphy
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Psychiatry and Mental health ,medicine.medical_specialty ,genetic structures ,History and Philosophy of Science ,mental disorders ,medicine ,Cognition ,Autistic spectrum ,Psychiatry ,Psychology ,behavioral disciplines and activities ,Applied Psychology ,Clinical psychology - Abstract
Autistic spectrum disorders (ASD), are a group of disorders characterised by qualitative abnormalities in social and emotional behaviour and are associated with restricted, stereotyped and repetitive interests and activities. There has been considerable understanding of ASD in recent years. This educational review paper focuses on four areas of interest and relevance to trainees preparing for the membership examination of the Royal College of Psychiatrists (MRCPsych): (a) diagnosing ASD; (b) epidemiology of ASD; (c) aetiology, including genetic, cognitive and neurochemical/neuropathological theories in ASD; and (d) treatment of ASD. Relevant papers are discussed and recommendations for further reading are provided.
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- 2005
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16. Recent developments in the genetics of schizophrenia
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Michael Gill and Kieran C. Murphy
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Psychiatry and Mental health ,medicine.medical_specialty ,History and Philosophy of Science ,Schizophrenia (object-oriented programming) ,medicine ,Biology ,Psychiatry ,Applied Psychology - Abstract
Objectives:To examine the evidence concerning the recent developments in the genetics of schizophrenia.Methods:An extensive literature search was performed and relevant papers were examined and analysed.Findings:There is overwhelming evidence that schizophrenia shows familial aggregation. Recent molecular genetic studies support the presence of susceptibility genes on chromosomes 6 and 22. In addition, an association between schizophrenia, the dopamine D3 receptor gene and the 5-HT2areceptor gene has also been demonstrated.Conclusions:Recent advances in DNA technology have paved the way for the detection of genes of major and minor effects in the aetiology of schizophrenia. If the presence of the recently identified susceptibility genes is confirmed, it is likely that these genes will be recognised in the near future.
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- 1996
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17. Father-son incest: case report and review of the literature
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Kieran C. Murphy and Rory K Shelley
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Psychiatry and Mental health ,Psychotherapist ,History and Philosophy of Science ,medicine ,Sexual orientation ,Anxiety ,medicine.symptom ,Psychology ,Applied Psychology ,Depression (differential diagnoses) - Abstract
A case report of father-son incest is described. A review of the literature suggests that father-son incest may be significantly under-reported. We suggest that this may be because it is seldom sought after and even less readily recognised. The possibility of the male incest victim should be considered in males who present with depression, severe anxiety, low self-esteem and difficulties with sexual orientation.
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- 1993
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18. Schizophrenia: common perceptions - Schizophrenia: Challenging the Orthodox. Edited by C McDonald, K Schultze, R Murray and P Wright. (221 pages; £39.95; ISBN 1841843776 pb.) Taylor & Francis: Basingstoke, UK. 2004
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Kieran C. Murphy
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Psychiatry and Mental health ,Wright ,Psychoanalysis ,History and Philosophy of Science ,Schizophrenia (object-oriented programming) ,Psychology ,Applied Psychology - Published
- 2006
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19. Schizophrenia, lung cancer and glutathione-S-transferase-μ
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Kieran C. Murphy, Michelle M. Graham, T Mantle, and Rory K Shelley
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Psychiatry and Mental health ,Glutathione S-transferase ,History and Philosophy of Science ,biology ,Schizophrenia ,business.industry ,medicine ,Cancer research ,biology.protein ,Lung cancer ,medicine.disease ,business ,Applied Psychology - Abstract
Objectives:Several reports have suggested that, despite the high prevalence of cigarette smoking, the incidence of lung cancer is lower than would be expected in patients with schizophrenia. In addition, patients with lung cancer have been shown to have a lower expression of glutathione-Stransferase-μ (GST-μ) compared to healthy controls. In this study, we tested the hypothesis that GST-μ was a trait marker that protected patients with schizophrenia from developing lung cancer.Methods:One hundred patients who fulfilled DSMIIIR criteria for schizophrenia were examined for the presence or absence of GST-μ.Results:Significantly more male (86%) and female patients (64%) were smokers compared to general population rates of 30% and 30% respectively (p < 0.0001). There were no significant differences in the expression of GST-μ in patients (48%) compared to controls (46%).Conclusions:We found no difference in the expression of GST-μ in patients with schizophrenia compared to normal controls. It is therefore unlikely that GST-μ acts as a trait marker protecting patients with schizophrenia from lung cancer. However, a significantly large smoking prevalence rate was ascertained in the patient population.
- Published
- 1996
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