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Your search keyword '"Yoshimichi Sai"' showing total 8 results
Start Over Author "Yoshimichi Sai" Journal iryo yakugaku (japanese journal of pharmaceutical health care and sciences)
8 results on '"Yoshimichi Sai"'

4. Aggregation in a Suspension of Lansoprazole OD Tablets and Levofloxacin Hydrate Tablets in Water

Author

Tsutomu Shimada, Takuya Suzuki, Yukio Suga, Yukiko Nakagawa, Yoshimichi Sai, and Yusuke Shimura

Subjects
03 medical and health sciences, 0302 clinical medicine, Chromatography, Levofloxacin, Chemistry, 030503 health policy & services, Lansoprazole, medicine, 0305 other medical science, Hydrate, Suspension (vehicle), 030226 pharmacology & pharmacy, medicine.drug
Published
2017

7. Pharmacokinetics Parameters in Drug Package Inserts (3)

Author

Yoshimichi Sai, Takashi Kano, Yuko Okada, Nao Kodama, Lisa Kanamoto, Kaori Morimoto, and Takuo Ogihara

Subjects
Pharmacokinetics, business.industry, Medicine, business, Drug package inserts, Biomedical engineering
Published
2011

8. Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients

Author

Shinji Nakao, Hideaki Maeba, Ryosei Nishimura, Mikie Koshiba, Naoto Nagata, Koichi Yokogawa, Yukio Suga, Junko Ishizaki, Syoichi Koizumi, Yoshimichi Sai, Yasuro Igarashi, Satsuki Ito, and Ken-ichi Miyamoto

Subjects
Voriconazole, medicine.medical_specialty, Pediatrics, Adult patients, business.industry, medicine.medical_treatment, Hematopoietic stem cell transplantation, Serum concentration, Surgery, Cmin, Long period, Plasma concentration, Medicine, Liver dysfunction, business, medicine.drug
Abstract

The purpose of this study was to investigate whether the trough plasma concentration of voriconazole (VRCZ) in the steady-state (Cmin) influences efficacy and safety in adult and pediatric patients.Treatment was successful in 75% of pediatric patients and 56% of adult patients,and there was no association between Cmin and efficacy.However,liver dysfunction occurred more frequently in the case that Cmin was over 4μg/mL in both adult and pediatric patients.Also,pediatric patients,especially those younger than 2 years,required a higher dose of VRCZ than adults to achieve a similar Cmin.We concluded that the use of VRCZ at a constant dose over a long period may lead to an increase in Cmin.Therefore,careful,continuous monitoring of the Cmin of VRCZ is necessary for pediatric patients,particularly recipients of hematopoietic stem cell transplantation.

Published
2010

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