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Start Over Author "Notari, Stefania" Journal iubmb life
4 results on '"Notari, Stefania"'

4. The extraordinary ligand binding properties of human serum albumin.

Author

Fasano, Mauro, Curry, Stephen, Terreno, Enzo, Galliano, Monica, Fanali, Gabriella, Narciso, Pasquale, Notari, Stefania, and Ascenzi, Paolo

Subjects
SERUM albumin, BLOOD proteins, LIGANDS (Biochemistry), COORDINATION compounds, BIOCHEMISTRY, PHARMACOKINETICS, ALLOSTERIC proteins
Abstract

Human serum albumin (HSA), the most prominent protein in plasma, binds different classes of ligands at multiple sites. HSA provides a depot for many compounds, affects pharmacokinetics of many drugs, holds some ligands in a strained orientation providing their metabolic modification, renders potential toxins harmless transporting them to disposal sites, accounts for most of the antioxidant capacity of human serum, and acts as a NO-carrier. The globular domain structural organization of monomeric HSA is at the root of its allosteric properties which are reminiscent of those of multimeric proteins. Here, structural, functional, biotechnological, and biomedical aspects of ligand binding to HSA are summarized. [ABSTRACT FROM AUTHOR]

Published
2005
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