1. Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease.
- Author
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Elliott, Paul, Chambers, John C., Weihua Zhang, Clarke, Robert, Hopewell, Jemma C., Peden, John F., Erdmann, Jeanette, Braund, Peter, Engert, James C., Bennett, Derrick, Coin, Lachlan, Ashby, Deborah, Tzoulaki, Ioanna, Brown, Ian J., Mt-Isa, Shahrul, McCarthy, Mark I., Peltonen, Leena, Freimer, Nelson B., Farrall, Martin, and Ruokonen, Aimo
- Subjects
C-reactive protein ,CORONARY disease ,MEDICAL genetics ,HEART disease genetics ,HUMAN genome ,META-analysis ,GENETICS - Abstract
The article discusses a study aimed at conducting a genome-wide association analysis to identify common genetic variants associated with C-reactive protein (CRP) levels and coronary heart disease. A mendelian randomization study of the most closely associated single-nucleotide polymorphism (SNP) in the CRP locus was conducted by the researchers. Findings were compared with that predicted from meta-analysis of observational studies of CRP levels. It was concluded that there was no causal association between CRP levels and coronary heart disease.
- Published
- 2009
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