1. Benefits of danazol treatment in patients with hemophilia A (classic hemophilia)
- Author
-
H R, Gralnick, P, Maisonneuve, Y, Sultan, and M E, Rick
- Subjects
Adult ,Male ,Factor VIII ,Time Factors ,Danazol ,Pregnadienes ,Humans ,Blood Transfusion ,Hemophilia A - Abstract
Danazol, an attenuated androgen, was given intermittently in three patients with hemophilia A. The rise in factor VIII activity with danazol treatment was associated with a fivefold decrease in hemorrhagic episodes and plasma concentrate product utilization when compared with similar periods without the drug. Four other patients with moderate hemophilia A who received danazol for 14 days had an increase of 400% to 850% in their factor VIII levels. Of four patients without detectable levels of factor VIII who were treated with danazol, two had elevations of the factor VIII level, to 3% and 4%, respectively. Danazol appears to be an effective treatment for patients with hemophilia A.
- Published
- 1985