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Your search keyword '"Knopman, David"' showing total 35 results
Start Over Author "Knopman, David" Journal jama neurology
35 results on '"Knopman, David"'

1. Clinicopathologic Heterogeneity and Glial Activation Patterns in Alzheimer Disease

Author

Kouri, Naomi, primary, Frankenhauser, Isabelle, additional, Peng, Zhongwei, additional, Labuzan, Sydney A., additional, Boon, Baayla D. C., additional, Moloney, Christina M., additional, Pottier, Cyril, additional, Wickland, Daniel P., additional, Caetano-Anolles, Kelsey, additional, Corriveau-Lecavalier, Nick, additional, Tranovich, Jessica F., additional, Wood, Ashley C., additional, Hinkle, Kelly M., additional, Lincoln, Sarah J., additional, Spychalla, A. J., additional, Senjem, Matthew L., additional, Przybelski, Scott A., additional, Engelberg-Cook, Erica, additional, Schwarz, Christopher G., additional, Kwan, Rain S., additional, Lesser, Elizabeth R., additional, Crook, Julia E., additional, Carter, Rickey E., additional, Ross, Owen A., additional, Lachner, Christian, additional, Ertekin-Taner, Nilüfer, additional, Ferman, Tanis J., additional, Fields, Julie A., additional, Machulda, Mary M., additional, Ramanan, Vijay K., additional, Nguyen, Aivi T., additional, Reichard, R. Ross, additional, Jones, David T., additional, Graff-Radford, Jonathan, additional, Boeve, Bradley F., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, Kantarci, Kejal, additional, Day, Gregory S., additional, Duara, Ranjan, additional, Graff-Radford, Neill R., additional, Dickson, Dennis W., additional, Lowe, Val J., additional, Vemuri, Prashanthi, additional, and Murray, Melissa E., additional

Published
2024
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2. Shapes of the Trajectories of 5 Major Biomarkers of Alzheimer Disease

Author

Jack, Clifford R, Vemuri, Prashanthi, Wiste, Heather J, Weigand, Stephen D, Lesnick, Timothy G, Lowe, Val, Kantarci, Kejal, Bernstein, Matt A, Senjem, Matthew L, Gunter, Jeffrey L, Boeve, Bradley F, Trojanowski, John Q, Shaw, Leslie M, Aisen, Paul S, Weiner, Michael W, Petersen, Ronald C, Knopman, David S, and Initiative, for the Alzheimer's Disease Neuroimaging

Subjects
Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Dementia, Brain Disorders, Aging, Alzheimer's Disease, Biomedical Imaging, Acquired Cognitive Impairment, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Research, Neurodegenerative, Neurological, Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Amyloid beta-Peptides, Aniline Compounds, Apolipoprotein E4, Biomarkers, Cognition Disorders, Cohort Studies, Cross-Sectional Studies, Female, Fluorodeoxyglucose F18, Hippocampus, Humans, Immunoassay, Magnetic Resonance Imaging, Male, Mental Status Schedule, Nonlinear Dynamics, Peptide Fragments, Positron-Emission Tomography, Thiazoles, tau Proteins, Alzheimer’s Disease Neuroimaging Initiative
Abstract

ObjectiveTo characterize the shape of the trajectories of Alzheimer disease biomarkers as a function of Mini-Mental State Examination (MMSE) score.Design and settingLongitudinal registries from the Mayo Clinic and the Alzheimer's Disease Neuroimaging Initiative.PatientsTwo different samples (n = 343 and n = 598) were created that spanned the cognitive spectrum from normal to Alzheimer disease dementia. Subgroup analyses were performed in members of both cohorts (n = 243 and n = 328) who were amyloid positive at baseline.Main outcome measuresThe shape of biomarker trajectories as a function of MMSE score, adjusted for age, was modeled and described as baseline (cross-sectional) and within-subject longitudinal effects. Biomarkers evaluated were cerebrospinal fluid (CSF) Aβ42 and tau levels, amyloid and fluorodeoxyglucose positron emission tomography imaging, and structural magnetic resonance imaging.ResultsBaseline biomarker values generally worsened (ie, nonzero slope) with lower baseline MMSE score. Baseline hippocampal volume, amyloid positron emission tomography, and fluorodeoxyglucose positron emission tomography values plateaued (ie, nonlinear slope) with lower MMSE score in 1 or more analyses. Longitudinally, within-subject rates of biomarker change were associated with worsening MMSE score. Nonconstant within-subject rates (deceleration) of biomarker change were found in only 1 model.ConclusionsBiomarker trajectory shapes by MMSE score were complex and were affected by interactions with age and APOE status. Nonlinearity was found in several baseline effects models. Nonconstant within-subject rates of biomarker change were found in only 1 model, likely owing to limited within-subject longitudinal follow-up. Creating reliable models that describe the full trajectories of Alzheimer disease biomarkers will require significant additional longitudinal data in individual participants.

Published
2012

3. Association Between Microinfarcts and Blood Pressure Trajectories

Author

Graff-Radford, Jonathan, Raman, Mekala R., Rabinstein, Alejandro A., Przybelski, Scott A., Lesnick, Timothy G., Boeve, Bradley F., Murray, Melissa E., Dickson, Dennis W., Reichard, R. Ross, Parisi, Joseph E., Knopman, David S., Petersen, Ronald C., Jack, Clifford R., Jr, and Kantarci, Kejal

Published
2018
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8. Association of Ischemic Stroke Incidence, Severity, and Recurrence With Dementia in the Atherosclerosis Risk in Communities Cohort Study

Author

Koton, Silvia, primary, Pike, James Russell, additional, Johansen, Michelle, additional, Knopman, David S., additional, Lakshminarayan, Kamakshi, additional, Mosley, Thomas, additional, Patole, Shalom, additional, Rosamond, Wayne D., additional, Schneider, Andrea L. C., additional, Sharrett, A. Richey, additional, Wruck, Lisa, additional, Coresh, Josef, additional, and Gottesman, Rebecca F., additional

Published
2022
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14. Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes

Author

Mielke, Michelle M., primary, Frank, Ryan D., additional, Dage, Jeffrey L., additional, Jeromin, Andreas, additional, Ashton, Nicholas J., additional, Blennow, Kaj, additional, Karikari, Thomas K., additional, Vanmechelen, Eugene, additional, Zetterberg, Henrik, additional, Algeciras-Schimnich, Alicia, additional, Knopman, David S., additional, Lowe, Val, additional, Bu, Guojun, additional, Vemuri, Prashanthi, additional, Graff-Radford, Jonathan, additional, Jack, Clifford R., additional, and Petersen, Ronald C., additional

Published
2021
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23. Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework

Author

Jack, Clifford R., primary, Therneau, Terry M., additional, Weigand, Stephen D., additional, Wiste, Heather J., additional, Knopman, David S., additional, Vemuri, Prashanthi, additional, Lowe, Val J., additional, Mielke, Michelle M., additional, Roberts, Rosebud O., additional, Machulda, Mary M., additional, Graff-Radford, Jonathan, additional, Jones, David T., additional, Schwarz, Christopher G., additional, Gunter, Jeffrey L., additional, Senjem, Matthew L., additional, Rocca, Walter A., additional, and Petersen, Ronald C., additional

Published
2019
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24. Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment

Author

Kern, Silke, primary, Syrjanen, Jeremy A., additional, Blennow, Kaj, additional, Zetterberg, Henrik, additional, Skoog, Ingmar, additional, Waern, Margda, additional, Hagen, Clinton E., additional, van Harten, Argonde C., additional, Knopman, David S., additional, Jack, Clifford R., additional, Petersen, Ronald C., additional, and Mielke, Michelle M., additional

Published
2019
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26. Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

Author

Wennberg, Alexandra M., primary, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Murray, Melissa E., additional, Whitwell, Jennifer L., additional, Liesinger, Amanda M., additional, Petrucelli, Leonard, additional, Boeve, Bradley F., additional, Parisi, Joseph E., additional, Knopman, David S., additional, Petersen, Ronald C., additional, Dickson, Dennis W., additional, and Josephs, Keith A., additional

Published
2018
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27. Association of Initial β-Amyloid Levels With Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment.

Author

Knopman, David S., Lundt, Emily S., Therneau, Terry M., Albertson, Sabrina M., Gunter, Jeffrey L., Senjem, Matthew L., Schwarz, Christopher G., Mielke, Michelle M., Machulda, Mary M., Boeve, Bradley F., Jones, David T., Graff-Radford, Jon, Vemuri, Prashanthi, Kantarci, Kejal, Lowe, Val J., Petersen, Ronald C., and Jack, Clifford R.

Published
2021
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28. Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting

Author

Roberts, Rosebud O., primary, Aakre, Jeremiah A., additional, Kremers, Walter K., additional, Vassilaki, Maria, additional, Knopman, David S., additional, Mielke, Michelle M., additional, Alhurani, Rabe, additional, Geda, Yonas E., additional, Machulda, Mary M., additional, Coloma, Preciosa, additional, Schauble, Barbara, additional, Lowe, Val J., additional, Jack, Clifford R., additional, and Petersen, Ronald C., additional

Published
2018
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29. Association of Excessive Daytime Sleepiness With Longitudinal β-Amyloid Accumulation in Elderly Persons Without Dementia

Author

Carvalho, Diego Z., primary, St Louis, Erik K., additional, Knopman, David S., additional, Boeve, Bradley F., additional, Lowe, Val J., additional, Roberts, Rosebud O., additional, Mielke, Michelle M., additional, Przybelski, Scott A., additional, Machulda, Mary M., additional, Petersen, Ronald C., additional, Jack, Clifford R., additional, and Vemuri, Prashanthi, additional

Published
2018
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30. Population-Based Prevalence of Cerebral Cavernous Malformations in Older Adults

Author

Flemming, Kelly D., primary, Graff-Radford, Jonathan, additional, Aakre, Jeremiah, additional, Kantarci, Kejal, additional, Lanzino, Giuseppe, additional, Brown, Robert D., additional, Mielke, Michelle M., additional, Roberts, Rosebud O., additional, Kremers, Walter, additional, Knopman, David S., additional, Petersen, Ronald C., additional, and Jack, Clifford R., additional

Published
2017
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31. Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals

Author

Vemuri, Prashanthi, primary, Knopman, David S., additional, Lesnick, Timothy G., additional, Przybelski, Scott A., additional, Mielke, Michelle M., additional, Graff-Radford, Jonathan, additional, Murray, Melissa E., additional, Roberts, Rosebud O., additional, Vassilaki, Maria, additional, Lowe, Val J., additional, Machulda, Mary M., additional, Jones, David T., additional, Petersen, Ronald C., additional, and Jack, Clifford R., additional

Published
2017
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33. Age, Sex, andAPOEε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span

Author

Jack, Clifford R., primary, Wiste, Heather J., additional, Weigand, Stephen D., additional, Knopman, David S., additional, Vemuri, Prashanthi, additional, Mielke, Michelle M., additional, Lowe, Val, additional, Senjem, Matthew L., additional, Gunter, Jeffrey L., additional, Machulda, Mary M., additional, Gregg, Brian E., additional, Pankratz, V. Shane, additional, Rocca, Walter A., additional, and Petersen, Ronald C., additional

Published
2015
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