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30 results on '"Holmes, Jonathan"'

1. Evaluation of the Intermittent Exotropia Questionnaire using Rasch analysis.

Author

Leske, David, Holmes, Jonathan, and Melia, B

Subjects
Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Exotropia, Female, Health Status, Humans, Infant, Male, Quality of Life, Reproducibility of Results, Sickness Impact Profile, Surveys and Questionnaires
Abstract

IMPORTANCE: The Intermittent Exotropia Questionnaire (IXTQ) is a patient, proxy, and parental report of quality of life specific to children with intermittent exotropia. We refine the IXTQ using Rasch analysis to improve reliability and validity. OBSERVATION: Rasch analysis was performed on responses of 575 patients with intermittent exotropia enrolled from May 15, 2008, through July 24, 2013, and their parents from each of the 4 IXTQ health-related quality-of-life questionnaires (child 5 through 7 years of age and child 8 through 17 years of age, proxy, and parent questionnaires). Questionnaire performance and structure were confirmed in a separate cohort of 379 patients with intermittent exotropia. One item was removed from the 12-item child and proxy questionnaires, and response options in the 8- to 17-year-old child IXTQ and proxy IXTQ were combined into 3 response options for both questionnaires. Targeting was relatively poor for the child and proxy questionnaires. For the parent questionnaire, 3 subscales (psychosocial, function, and surgery) were evident. One item was removed from the psychosocial subscale. Resulting subscales had appropriate targeting. CONCLUSIONS AND RELEVANCE: The Rasch-revised IXTQ may be a useful instrument for determining how intermittent exotropia affects health-related quality of life of children with intermittent exotropia and their parents, particularly for cohort studies.

Published
2015

7. Low-Dose 0.01% Atropine Eye Drops vs Placebo for Myopia Control: A Randomized Clinical Trial.

Author

Repka, Michael X., Weise, Katherine K., Chandler, Danielle L., Wu, Rui, Melia, B. Michele, Manny, Ruth E., Kehler, Lori Ann F., Jordan, Catherine O., Raghuram, Aparna, Summers, Allison I., Lee, Katherine A., Petersen, David B., Erzurum, S. A., Pang, Yi, Lenhart, Phoebe D., Ticho, Benjamin H., Beck, Roy W., Kraker, Raymond T., Holmes, Jonathan M., and Cotter, Susan A.

Published
2023
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17. Plasma Levels of Bevacizumab and Vascular Endothelial Growth Factor After Low-Dose Bevacizumab Treatment for Retinopathy of Prematurity in Infants.

Author

Hartnett, M. Elizabeth, Wallace, David K., Dean, Trevano W., Li, Zhuokai, Boente, Charline S., Dosunmu, Eniolami O., Freedman, Sharon F., Golden, Richard P., Kong, Lingkun, Prakalapakorn, S. Grace, Repka, Michael X., Smith, Lois E., Wang, Haibo, Kraker, Raymond T., Cotter, Susan A., Holmes, Jonathan M., and Writing Committee for the Pediatric Eye Disease Investigator Group

Published
2022
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18. Visual Acuity and Ophthalmic Outcomes 5 Years After Cataract Surgery Among Children Younger Than 13 Years.

Author

Repka, Michael X., Dean, Trevano W., Kraker, Raymond T., Li, Zhuokai, Yen, Kimberly G., de Alba Campomanes, Alejandra G., Young, Marielle P., Rahmani, Bahram, Haider, Kathryn M., Whitehead, George F., Lambert, Scott R., Kurup, Sudhi P., Kraus, Courtney L., Cotter, Susan A., Holmes, Jonathan M., and Pediatric Eye Disease Investigator Group

Published
2022
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21. Assessment of Pediatric Optic Neuritis Visual Acuity Outcomes at 6 Months.

Author

Pineles, Stacy L., Repka, Michael X., Liu, Grant T., Waldman, Amy T., Borchert, Mark S., Khanna, Sangeeta, Heidary, Gena, Graves, Jennifer S., Shah, Veeral S., Kupersmith, Mark J., Kraker, Raymond T., Wallace, David K., Cotter, Susan A., Holmes, Jonathan M., and Writing Committee for the Pediatric Eye Disease Investigator Group (PEDIG)

Published
2020
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22. Short-term Outcomes After Very Low-Dose Intravitreous Bevacizumab for Retinopathy of Prematurity.

Author

Wallace, David K., Kraker, Raymond T., Freedman, Sharon F., Crouch, Eric R., Bhatt, Amit R., Hartnett, M. Elizabeth, Yang, Michael B., Rogers, David L., Hutchinson, Amy K., VanderVeen, Deborah K., Haider, Kathryn M., Siatkowski, R. Michael, Dean, Trevano W., Beck, Roy W., Repka, Michael X., Smith, Lois E., Good, William V., Kong, Lingkun, Cotter, Susan A., and Holmes, Jonathan M.

Published
2020
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24. Overminus Lens Therapy for Children 3 to 10 Years of Age With Intermittent Exotropia: A Randomized Clinical Trial

Author

Chen, Angela M., Erzurum, S. Ayse, Chandler, Danielle L., Hercinovic, Amra, Melia, B. Michele, Bhatt, Amit R., Suh, Donny W., Vricella, Marilyn, Erickson, John W., Miller, Aaron M., Marsh, Justin D., Bodack, Marie I., Martinson, Stacy R., Titelbaum, Jenna R., Gray, Michael E., Holtorf, Hannah L., Kong, Lingkun, Kraker, Raymond T., Rahmani, Bahram, Shah, Birva K., Holmes, Jonathan M., and Cotter, Susan A.

Abstract

IMPORTANCE: This is the first large-scale randomized clinical trial evaluating the effectiveness and safety of overminus spectacle therapy for treatment of intermittent exotropia (IXT). OBJECTIVE: To evaluate the effectiveness of overminus spectacles to improve distance IXT control. DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial conducted at 56 clinical sites between January 2017 and January 2019 associated with the Pediatric Eye Disease Investigator Group enrolled 386 children aged 3 to 10 years with IXT, a mean distance control score of 2 or worse, and a refractive error between 1.00 and −6.00 diopters (D). Data analysis was performed from February to December 2020. INTERVENTIONS: Participants were randomly assigned to overminus spectacle therapy (−2.50 D for 12 months, then −1.25 D for 3 months, followed by nonoverminus spectacles for 3 months) or to nonoverminus spectacle use. MAIN OUTCOMES AND MEASURES: Primary and secondary outcomes were the mean distance IXT control scores of participants examined after 12 months of treatment (primary outcome) and at 18 months (3 months after treatment ended) assessed by an examiner masked to treatment group. Change in refractive error from baseline to 12 months was compared between groups. Analyses were performed using the intention-to-treat population. RESULTS: The mean (SD) age of 196 participants randomized to overminus therapy and 190 participants randomized to nonoverminus treatment was 6.3 (2.1) years, and 226 (59%) were female. Mean distance control at 12 months was better in participants treated with overminus spectacles than with nonoverminus spectacles (1.8 vs 2.8 points; adjusted difference, −0.8; 95% CI, −1.0 to −0.5; P < .001). At 18 months, there was little or no difference in mean distance control between overminus and nonoverminus groups (2.4 vs 2.7 points; adjusted difference, −0.2; 95% CI, −0.5 to 0.04; P = .09). Myopic shift from baseline to 12 months was greater in the overminus than the nonoverminus group (−0.42 D vs −0.04 D; adjusted difference, −0.37 D; 95% CI, −0.49 to −0.26 D; P < .001), with 33 of 189 children (17%) in the overminus group vs 2 of 169 (1%) in the nonoverminus group having a shift higher than 1.00 D. CONCLUSIONS AND RELEVANCE: Children 3 to 10 years of age had improved distance exotropia control when assessed wearing overminus spectacles after 12 months of overminus treatment; however, this treatment was associated with increased myopic shift. The beneficial effect of overminus lens therapy on distance exotropia control was not maintained after treatment was tapered off for 3 months and children were examined 3 months later. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02807350

Published
2021
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28. Assessment of Lower Doses of Intravitreous Bevacizumab for Retinopathy of Prematurity: A Phase 1 Dosing Study.

Author

Wallace, David K., Kraker, Raymond T., Freedman, Sharon F., Crouch, Eric R., Hutchinson, Amy K., Bhatt, Amit R., Rogers, David L., Yang, Michael B., Haider, Kathryn M., VanderVeen, Deborah K., Siatkowski, R. Michael, Dean, Trevano W., Beck, Roy W., Repka, Michael X., Smith, Lois E., Good, William V., Hartnett, Mary Elizabeth, Lingkun Kong, Holmes, Jonathan M., and Kong, Lingkun

Published
2017
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