20 results on '"O'Donovan, Michael"'
Search Results
2. Ultrarare Coding Variants and Cognitive Function in Schizophrenia
- Author
-
Creeth, Hugo D. J., primary, Rees, Elliott, additional, Legge, Sophie E., additional, Dennison, Charlotte A., additional, Holmans, Peter, additional, Walters, James T. R., additional, O’Donovan, Michael C., additional, and Owen, Michael J., additional
- Published
- 2022
- Full Text
- View/download PDF
3. Genetic Liabilities Differentiating Bipolar Disorder, Schizophrenia, and Major Depressive Disorder, and Phenotypic Heterogeneity in Bipolar Disorder
- Author
-
Richards, Alexander L., primary, Cardno, Alastair, additional, Harold, Gordon, additional, Craddock, Nicholas J., additional, Di Florio, Arianna, additional, Jones, Lisa, additional, Gordon-Smith, Katherine, additional, Jones, Ian, additional, Sellers, Ruth, additional, Walters, James T. R., additional, Holmans, Peter A., additional, Owen, Michael J., additional, and O’Donovan, Michael C., additional
- Published
- 2022
- Full Text
- View/download PDF
4. Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder
- Author
-
Allardyce, Judith, Leonenko, Ganna, Hamshere, Marian, Pardiñas, Antonio F., Forty, Liz, Knott, Sarah, Gordon-Smith, Katherine, Porteous, David J., Haywood, Caroline, Di Florio, Arianna, Jones, Lisa, McIntosh, Andrew M., Owen, Michael J., Holmans, Peter, Walters, James T. R., Craddock, Nicholas, Jones, Ian, O’Donovan, Michael C., and Escott-Price, Valentina
- Published
- 2018
- Full Text
- View/download PDF
5. Associations Between Schizophrenia Polygenic Liability, Symptom Dimensions, and Cognitive Ability in Schizophrenia
- Author
-
Legge, Sophie E., primary, Cardno, Alastair G., additional, Allardyce, Judith, additional, Dennison, Charlotte, additional, Hubbard, Leon, additional, Pardiñas, Antonio F., additional, Richards, Alexander, additional, Rees, Elliott, additional, Di Florio, Arianna, additional, Escott-Price, Valentina, additional, Zammit, Stanley, additional, Holmans, Peter, additional, Owen, Michael J., additional, O’Donovan, Michael C., additional, and Walters, James T. R., additional
- Published
- 2021
- Full Text
- View/download PDF
6. Phenotypic Manifestation of Genetic Risk for Schizophrenia During Adolescence in the General Population
- Author
-
Jones, Hannah J., Stergiakouli, Evie, Tansey, Katherine E., Hubbard, Leon, Heron, Jon, Cannon, Mary, Holmans, Peter, Lewis, Glyn, Linden, David E. J., Jones, Peter B., Davey Smith, George, O’Donovan, Michael C., Owen, Michael J., Walters, James T., and Zammit, Stanley
- Published
- 2016
- Full Text
- View/download PDF
7. Association of Antihypertensive Drug Target Genes With Psychiatric Disorders
- Author
-
Chauquet, Solal, primary, Zhu, Zhihong, additional, O’Donovan, Michael C., additional, Walters, James T. R., additional, Wray, Naomi R., additional, and Shah, Sonia, additional
- Published
- 2021
- Full Text
- View/download PDF
8. Association of Recent Stressful Life Events With Mental and Physical Health in the Context of Genomic and Exposomic Liability for Schizophrenia
- Author
-
Pries, Lotta-Katrin, primary, van Os, Jim, additional, ten Have, Margreet, additional, de Graaf, Ron, additional, van Dorsselaer, Saskia, additional, Bak, Maarten, additional, Lin, Bochao D., additional, van Eijk, Kristel R., additional, Kenis, Gunter, additional, Richards, Alexander, additional, O’Donovan, Michael C., additional, Luykx, Jurjen J., additional, Rutten, Bart P. F., additional, and Guloksuz, Sinan, additional
- Published
- 2020
- Full Text
- View/download PDF
9. Implication of a Rare Deletion at Distal 16p11.2 in Schizophrenia
- Author
-
Guha, Saurav, Rees, Elliott, Darvasi, Ariel, Ivanov, Dobril, Ikeda, Masashi, Bergen, Sarah E., Magnusson, Patrik K., Cormican, Paul, Morris, Derek, Gill, Michael, Cichon, Sven, Rosenfeld, Jeffrey A., Lee, Annette, Gregersen, Peter, Kane, John M., Malhotra, Anil K., Rietschel, Marcella, Nöthen, Markus, Degenhardt, Franziska, Priebe, Lutz, Breuer, René, Strohmaier, Jana, Ruderfer, Douglas M., Moran, Jennifer L., Chambert, Kimberly D., Sanders, Alan R., Shi, Jianxin, Kendler, Kenneth, Riley, Brien, O’Neill, Tony, Walsh, Dermot, Malhotra, Dheeraj, Corvin, Aiden, Purcell, Shaun, Sklar, Pamela, Iwata, Nakao, Hultman, Christina M., Sullivan, Patrick F., Sebat, Jonathan, McCarthy, Shane, Gejman, Pablo V., Levinson, Douglas F., Owen, Michael J., O’Donovan, Michael C., Lencz, Todd, and Kirov, George
- Published
- 2013
- Full Text
- View/download PDF
10. Comparison of Genetic Liability for Sleep Traits Among Individuals With Bipolar Disorder I or II and Control Participants
- Author
-
Lewis, Katie J. S., primary, Richards, Alexander, additional, Karlsson, Robert, additional, Leonenko, Ganna, additional, Jones, Samuel E., additional, Jones, Hannah J., additional, Gordon-Smith, Katherine, additional, Forty, Liz, additional, Escott-Price, Valentina, additional, Owen, Michael J., additional, Weedon, Michael N., additional, Jones, Lisa, additional, Craddock, Nick, additional, Jones, Ian, additional, Landén, Mikael, additional, O’Donovan, Michael C., additional, and Di Florio, Arianna, additional
- Published
- 2020
- Full Text
- View/download PDF
11. Association of Genetic Liability to Psychotic Experiences With Neuropsychotic Disorders and Traits
- Author
-
Legge, Sophie E., primary, Jones, Hannah J., additional, Kendall, Kimberley M., additional, Pardiñas, Antonio F., additional, Menzies, Georgina, additional, Bracher-Smith, Matthew, additional, Escott-Price, Valentina, additional, Rees, Elliott, additional, Davis, Katrina A. S., additional, Hotopf, Matthew, additional, Savage, Jeanne E., additional, Posthuma, Danielle, additional, Holmans, Peter, additional, Kirov, George, additional, Owen, Michael J., additional, O’Donovan, Michael C., additional, Zammit, Stanley, additional, and Walters, James T. R., additional
- Published
- 2019
- Full Text
- View/download PDF
12. Characterizing Developmental Trajectories and the Role of Neuropsychiatric Genetic Risk Variants in Early-Onset Depression
- Author
-
Rice, Frances, Riglin, Lucy, Thapar, Ajay K, Heron, Jon, Anney, Richard, O'Donovan, Michael C, and Thapar, Anita
- Subjects
Male ,Depressive Disorder, Major ,Adolescent ,Depression ,Research ,Mental Disorders ,Comorbidity ,Attention Deficit Disorder with Hyperactivity ,Risk Factors ,mental disorders ,Disease Progression ,Schizophrenia ,Online First ,Humans ,Female ,Genetic Predisposition to Disease ,Longitudinal Studies ,Prospective Studies ,Age of Onset ,Child ,Original Investigation - Abstract
Key Points Question Do neuropsychiatric disorder genetic risk variants influence developmental trajectories of depression in youth? Findings In this population-based study including 7543 adolescents, distinct depression trajectory classes were identified. A later-adolescence–onset class (17.3% of the sample) showed a typical depression trajectory and was associated with major depressive disorder risk alleles, and an early-adolescence–onset class (9.0%) showed clinically significant symptoms at age 12 years and was associated with schizophrenia and attention-deficit hyperactivity disorder genetic risk, childhood attention-deficit hyperactivity disorder, and neurodevelopmental traits. Meaning Depression in youth is heterogeneous; findings are consistent with emerging evidence for a neurodevelopmental component to some cases of depression and that this component is more likely when onset is very early., Importance Depression often first manifests in adolescence. Thereafter, individual trajectories vary substantially, but it is not known what shapes depression trajectories in youth. Adult studies suggest that genetic risk for schizophrenia, a psychiatric disorder with a neurodevelopmental component, may contribute to an earlier onset of depression. Objective To test the hypothesis that there are distinct trajectories of depressive symptoms and that genetic liability for neurodevelopmental psychiatric disorders (eg, schizophrenia, attention deficit/hyperactivity disorder [ADHD]), as well as for major depressive disorder (MDD), contribute to early-onset depression. Design, Setting, and Participants The Avon Longitudinal Study of Parents and Children is an ongoing, prospective, longitudinal, population-based cohort that has been collecting data since September 6, 1990, including data on 7543 adolescents with depressive symptoms at multiple time points. The present study was conducted between November 10, 2017, and August 14, 2018. Main Outcomes and Measures Trajectories based on self-reported depressive symptoms dichotomized by the clinical cutpoint; MDD, schizophrenia, and ADHD polygenic risk score (PRS) were predictors. Results In 7543 adolescents with depression data on more than 1 assessment point between a mean (SD) age of 10.64 (0.25) years and 18.65 (0.49) years (3568 [47.3%] male; 3975 [52.7%] female), 3 trajectory classes were identified: persistently low (73.7%), later-adolescence onset (17.3%), and early-adolescence onset (9.0%). The later-adolescence–onset class was associated with MDD genetic risk only (MDD PRS: odds ratio [OR], 1.27; 95% CI, 1.09-1.48; P = .003). The early-adolescence–onset class was also associated with MDD genetic risk (MDD PRS: OR, 1.24; 95% CI, 1.06-1.46; P = .007) but additionally with genetic risk for neurodevelopmental disorders (schizophrenia PRS: OR, 1.22; 95% CI, 1.04-1.43; P = .01; ADHD PRS: OR, 1.32; 95% CI, 1.13-1.54; P, This population-based study examines the association between genetic risk variants for neuropsychiatric disorders and the age at onset and trajectories of depression in children.
- Published
- 2018
13. Association of Rare Copy Number Variants With Risk of Depression
- Author
-
Kendall, Kimberley Marie, primary, Rees, Elliott, additional, Bracher-Smith, Matthew, additional, Legge, Sophie, additional, Riglin, Lucy, additional, Zammit, Stanley, additional, O’Donovan, Michael Conlon, additional, Owen, Michael John, additional, Jones, Ian, additional, Kirov, George, additional, and Walters, James Tynan Rhys, additional
- Published
- 2019
- Full Text
- View/download PDF
14. Characterizing Developmental Trajectories and the Role of Neuropsychiatric Genetic Risk Variants in Early-Onset Depression
- Author
-
Rice, Frances, primary, Riglin, Lucy, additional, Thapar, Ajay K., additional, Heron, Jon, additional, Anney, Richard, additional, O’Donovan, Michael C., additional, and Thapar, Anita, additional
- Published
- 2019
- Full Text
- View/download PDF
15. Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations
- Author
-
Van Hemert, Albert M., Porteous, David J., O'Donovan, Michael C., McIntosh, Andrew M., Lewis, Glyn, Hayward, Caroline, Traylor, Matthew, Thomson, Pippa A., Tansey, Katherine E., Smith, Daniel J., Owen, Michael J., O'Reilly, Paul F., McGuffin, Peter, Marchini, Jonathan, MacIntyre, Donald J., Kretzschmar, Warren W., Hall, Lynsey S., Gaspar, Helena A., Escott-Price, Valentina, Eley, Thalia C., Deary, Ian J., Davies, Gail, Craddock, Nick, Coleman, Jonathan R.I., Clarke, Toni-Kim, Cai, Na, Blackwood, Douglas H.R., Adams, Mark J., Rivera, Margarita, Mullins, Niamh, Lewis, Cathryn, Kan, Carol, Dehghan, Abbas, Breen, Gerome, Sullivan, Patrick F., Borglum, Anders D., Levinson, Douglas F., Werge, Thomas, Weissman, Myrna M., Volzke, Henry, Uher, Rudolf, Tiemeier, Henning, Stefansson, Kari, Smoller, Jordan W., Schulze, Thomas G., Schaefer, Catherine, Potash, James B., Trubetskoy, Vassily, Treutlein, Jens, Thorgeirsson, Thorgeir E., Thompson, Wesley, Teismann, Henning, Steinberg, Stacy, Stefansson, Hreinn, Smit, Johannes H., Sinnamon, Grant C.B., Sigurdsson, Engilbert, Shyn, Stanley I., Shi, Jianxin, Shen, Ling, Schulte, Eva C., Schoevers, Robert, Mirza, Saira Saeed, Riley, Brien P., Rice, John P., Qvist, Per, Quiroz, Jorge A., Posthuma, Danielle, Pettersson, Erik, Peterson, Roseann E., Pedersen, Marianne Giortz, Pedersen, Carsten Bocker, Painter, Jodie N., Oskarsson, Hogni, Nyholt, Dale R., Nivard, Michel G., Ng, Bernard, Mostafavi, Sara, Montgomery, Grant W., Mondimore, Francis M., Milani, Lili, Mihailov, Evelin, Middeldorp, Christel M., Mehta, Divya, Medland, Sarah E., McGrath, Patrick, Mbarek, Hamdi, Maier, Wolfgang, Maier, Robert M., MacKinnon, Dean F., Lind, Penelope A., Li, Yihan, Kutalik, Zoltan, Krogh, Jesper, Kraft, Julia, Kohane, Isaac S., Knowles, James A., Jorgenson, Eric, Jansen, Rick, Ising, Marcus, Hougaard, David M., Hottenga, Jouke-Jan, Horn, Carsten, Hoffmann, Per, Hickie, Ian B., Herms, Stefan, Hansen, Thomas F., Hansen, Christine Soholm, Grove, Jakob, Gordon, Scott D., Goes, Fernando S., Frank, Josef, Finucane, Hilary K., Kiadeh, Farnush Farhadi Hassan, Dunn, Erin C., Dolan, Conor V., Direk, Nese, Derks, Eske M., Degenhardt, Franziska, Crawford, Gregory E., Couvy-Duchesne, Baptiste, Colodro-Conde, Lucia, Christensen, Jane Hvarregaard, Castelao, Enrique, Bybjerg-Grauholm, Jonas, Buttenschon, Henriette N., Bryois, Julien, Bigdeli, Tim B., Beekman, Aartjan T.F., Bakvad-Hansen, Marie, Bacanu, Silviu-Alin, Andlauer, Till F.M., Air, Tracy M., Agerbo, Esben, Abdellaoui, Abdel, Byrne, Enda M., Mattheisen, Manuel, Ripke, Stephan, Penninx, Brenda W.J.H., Boomsma, Dorret I., Wray, Naomi R., Van Der Auwera, Sandra, Teumer, Alexander, Strohmaier, Jana, Streit, Fabian, Rietschel, Marcella, Preisig, Martin, Pistis, Giorgio, Nauck, Matthias, Homuth, Georg, Grabe, Hans J., Forstner, Andreas J., Baune, Bernhard T., Peyrot, Wouter J., Lamers, Femke, Milaneschi, Yuri, Gill, Michael, Binder, Elisabeth B., Trzaskowski, Maciej, Perlis, Roy H., Pedersen, Nancy L., Paciga, Sara A., Nothen, Markus M., Nordentoft, Merete, Muller-Myhsok, Bertram, Mortensen, Preben Bo, Mors, Ole, Metspalu, Andres, Martin, Nicholas G., Magnusson, Patrik K., Madden, Pamela A.F., Lucae, Susanne, Li, Qingqin S., Kloiber, Stefan, Kendler, Kenneth S., Heath, Andrew C., Hamilton, Steven P., Esko, Tonu, Domschke, Katharina, Domenici, Enrico, DePaulo, J. Raymond, De Geus, E.J.C., Dannlowski, Udo, Cichon, Sven, Arolt, Volker, Zhang, Futao, Yang, Jian, Xi, Hualin S., Wu, Yang, Witt, Stephanie H., Willemsen, Gonneke, Wellmann, Jurgen, Weinsheimer, Shantel Marie, Webb, Bradley T., Wang, Yunpeng, Visscher, Peter M., Viktorin, Alexander, Umbricht, Daniel, Uitterlinden, Andre G., Berger, Klaus, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Psychiatry, APH - Digital Health, Biological Psychology, Clinical Psychology, APH - Methodology, Epidemiology, Urology, Child and Adolescent Psychiatry / Psychology, Internal Medicine, Medical Informatics, and Immunology
- Subjects
Netherlands Twin Register (NTR) ,Adult ,Male ,medicine.medical_specialty ,International Cooperation ,Population ,Genome-wide association study ,Overweight ,Weight Gain ,behavioral disciplines and activities ,Body Mass Index ,03 medical and health sciences ,0302 clinical medicine ,SDG 3 - Good Health and Well-being ,Internal medicine ,mental disorders ,medicine ,Journal Article ,Humans ,Genetic Predisposition to Disease ,Obesity ,Psychiatry ,education ,Problem Solving ,Depression (differential diagnoses) ,Original Investigation ,Craving ,Psychiatric Status Rating Scales ,education.field_of_study ,Depressive Disorder, Major ,Odds ratio ,medicine.disease ,030227 psychiatry ,Multicenter Study ,Diagnostic and Statistical Manual of Mental Disorders ,Psychiatry and Mental health ,C-Reactive Protein ,Cohort ,Major depressive disorder ,Female ,medicine.symptom ,Psychology ,Body mass index ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
© 2017 American Medical Association. All rights reserved.IMPORTANCE The association between major depressive disorder (MDD) and obesitymay stem from shared immunometabolic mechanisms particularly evident in MDD with atypical features, characterized by increased appetite and/or weight (A/W) during an active episode. OBJECTIVE To determine whether subgroups of patients with MDD stratified according to the A/W criterion had a different degree of genetic overlap with obesity-related traits (body mass index [BMI] and levels of C-reactive protein [CRP] and leptin). DESIGN, SETTING, AND PATIENTS This multicenter study assembled genome-wide genotypic and phenotypic measures from 14 data sets of the Psychiatric Genomics Consortium. Data sets were drawn from case-control, cohort, and population-based studies, including 26 628 participants with established psychiatric diagnoses and genome-wide genotype data. Data on BMI were available for 15 237 participants. Data were retrieved and analyzed from September 28, 2015, through May 20, 2017. MAIN OUTCOMES AND MEASURES Lifetime DSM-IV MDDwas diagnosed using structured diagnostic instruments. Patients with MDD were stratified into subgroups according to change in the DSM-IV A/W symptoms as decreased or increased. RESULTS Data included 11 837 participants with MDD and 14 791 control individuals, for a total of 26 628 participants (59.1% female and 40.9%male). Among participants with MDD, 5347 (45.2%) were classified in the decreased A/W and 1871 (15.8%) in the increased A/W subgroups. Common genetic variants explained approximately 10% of the heritability in the 2 subgroups. The increased A/W subgroup showed a strong and positive genetic correlation (SE) with BMI (0.53 [0.15]; P = 6.3 × 10-4), whereas the decreased A/W subgroup showed an inverse correlation (-0.28 [0.14]; P = .06). Furthermore, the decreased A/W subgroup had a higher polygenic risk for increased BMI (odds ratio [OR], 1.18; 95%CI, 1.12-1.25; P = 1.6 × 10-10) and levels of CRP (OR, 1.08; 95%CI, 1.02-1.13; P = 7.3 × 10-3) and leptin (OR, 1.09; 95%CI, 1.06-1.12; P = 1.7 × 10-3). CONCLUSIONS AND RELEVANCE The phenotypic associations between atypical depressive symptoms and obesity-related traits may arise from shared pathophysiologic mechanisms in patients with MDD. Development of treatments effectively targeting immunometabolic dysregulations may benefit patients with depression and obesity, both syndromes with important disability.
- Published
- 2017
16. Association of Genetic Risk Variants With Attention-Deficit/Hyperactivity Disorder Trajectories in the General Population
- Author
-
Riglin, Lucy, primary, Collishaw, Stephan, additional, Thapar, Ajay K., additional, Dalsgaard, Søren, additional, Langley, Kate, additional, Smith, George Davey, additional, Stergiakouli, Evie, additional, Maughan, Barbara, additional, O’Donovan, Michael C., additional, and Thapar, Anita, additional
- Published
- 2016
- Full Text
- View/download PDF
17. Analysis of Intellectual Disability Copy Number Variants for Association With Schizophrenia
- Author
-
Rees, Elliott, primary, Kendall, Kimberley, additional, Pardiñas, Antonio F., additional, Legge, Sophie E., additional, Pocklington, Andrew, additional, Escott-Price, Valentina, additional, MacCabe, James H., additional, Collier, David A., additional, Holmans, Peter, additional, O’Donovan, Michael C., additional, Owen, Michael J., additional, Walters, James T. R., additional, and Kirov, George, additional
- Published
- 2016
- Full Text
- View/download PDF
18. A Breakthrough in Schizophrenia Genetics
- Author
-
Kendler, Kenneth S., primary and O'Donovan, Michael C., additional
- Published
- 2014
- Full Text
- View/download PDF
19. The Genetic Architecture of Depression in Individuals of East Asian Ancestry
- Author
-
Giannakopoulou, Olga, Lin, Kuang, Meng, Xiangrui, Su, Mei-Hsin, Kuo, Po-Hsiu, Peterson, Roseann E., Awasthi, Swapnil, Moscati, Arden, Coleman, Jonathan R. I., Bass, Nick, Millwood, Iona Y., Chen, Yiping, Chen, Zhengming, Chen, Hsi-Chung, Lu, Mong-Liang, Huang, Ming-Chyi, Chen, Chun-Hsin, Stahl, Eli A., Loos, Ruth J. F., Mullins, Niamh, Ursano, Robert J., Kessler, Ronald C., Stein, Murray B., Sen, Srijan, Scott, Laura J., Burmeister, Margit, Fang, Yu, Tyrrell, Jess, Jiang, Yunxuan, Tian, Chao, McIntosh, Andrew M., Ripke, Stephan, Dunn, Erin C., Kendler, Kenneth S., Walters, Robin G., Lewis, Cathryn M., Kuchenbaecker, Karoline, Wray, Naomi R., Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F. M., Bacanu, Silviu-Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T. F., Bigdeli, Tim B., Binder, Elisabeth B., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane Hvarregaard, Clarke, Toni-Kim, Colodro-Conde, Lucía, Coon, Hilary, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Degenhardt, Franziska, Derks, Eske M., Direk, Nese, Dolan, Conor V., Eley, Thalia C., Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K., Foo, Jerome C., Forstner, Andreas J., Frank, Josef, Gaspar, Héléna A., Gill, Michael, Goes, Fernando S., Gordon, Scott D., Grove, Jakob, Hall, Lynsey S., Hansen, Christine Søholm, Hansen, Thomas F., Herms, Stefan, Hickie, Ian B., Hoffmann, Per, Homuth, Georg, Horn, Carsten, Hottenga, Jouke-Jan, Howard, David M., Hougaard, David M., Ising, Marcus, Jansen, Rick, Jones, Ian, Jones, Lisa A., Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Kutalik, Zoltán, Li, Yihan, Lind, Penelope A., Luykx, Jurjen J., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Mondimore, Francis M., Montgomery, Grant W., Mostafavi, Sara, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O'Reilly, Paul F., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Pettersson, Erik, Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Sinnamon, Grant C. B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thompson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T, Berger, Klaus, Boomsma, Dorret I., Cichon, Sven, Dannlowski, Udo, de Geus, EJC, DePaulo, J. Raymond, Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela AF, Magnusson, Patrik K., Martin, Nicholas G., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nordentoft, Merete, Nöthen, Markus M., O'Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda WJH, Perlis, Roy H., Porteous, David J., Potash, James B., Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M., Werge, Thomas, Levinson, Douglas F., Breen, Gerome, Børglum, Anders D., Sullivan, Patrick F., Agee, Michelle, Aslibekyan, Stella, Auton, Adam, Babalola, Elizabeth, Bell, Robert K., Bielenberg, Jessica, Bryc, Katarzyna, Bullis, Emily, Cameron, Briana, Coker, Daniella, Cuellar Partida, Gabriel, Dhamija, Devika, Das, Sayantan, Elson, Sarah L., Filshtein, Teresa, Fletez-Brant, Kipper, Fontanillas, Pierre, Freyman, Will, Gandhi, Pooja M., Heilbron, Karl, Hicks, Barry, Hinds, David A., Huber, Karen E., Jewett, Ethan M., Kleinman, Aaron, Kukar, Katelyn, Lane, Vanessa, Lin, Keng-Han, Lowe, Maya, Luff, Marie K., McCreight, Jennifer C., McIntyre, Matthew H., McManus, Kimberly F., Micheletti, Steven J., Moreno, Meghan E., Mountain, Joanna L., Mozaffari, Sahar V., Nandakumar, Priyanka, Noblin, Elizabeth S., O'Connell, Jared, Petrakovitz, Aaron A., Poznik, G. David, Schumacher, Morgan, Shastri, Anjali J., Shelton, Janie F., Shi, Jingchunzi, Shringarpure, Suyash, Tran, Vinh, Tung, Joyce Y., Wang, Xin, Wang, Wei, Weldon, Catherine H., Wilton, Peter, Avery, Daniel, Bennett, Derrick, Bian, Zheng, Boxall, Ruth, Bragg, Fiona, Chan, Ka Hung, Chang, Liang, Chang, Yumei, Chen, Biyun, Chen, Jinyan, Chen, Junshi, Chen, Naying, Chen, Ningyu, Chen, Xiaofang, Cheng, Liang, Clarke, Johnathan, Clarke, Robert, Collins, Rory, Dong, Caixia, Du, Huaidong, Du, Ranran, Fairhurst-Hunter, Zammy, Fan, Lei, Feng, Shixian, Fu, Zhongxi, Gan, Wei, Gao, Ruqin, Gao, Yulian, Ge, Pengfei, Gilbert, Simon, Gong, Weiwei, Gu, Qijun, Guo, Yu, Guo, Zhendong, Guo, Ziyan, Hacker, Alex, Han, Xiao, Hariri, Parisa, He, Pan, He, Tianyou, Hill, Mike, Holmes, Michael, Hou, Can, Hou, Wei, Hu, Chen, Hu, Ruying, Hu, Ximin, Hu, Yihe, Hua, Hua, Hua, Yujie, Huang, Yuelong, Im, Pek Kei, Iona, Andri, Jiang, Qilian, Jin, Jianrong, Kakkoura, Maria, Kang, Quan, Kartsonaki, Christiana, Kerosi, Rene, Kong, Ling, Lan, Jian, Lancaster, Garry, Li, Feifei, Li, Huimei, Li, Jianguo, Li, Liming, Li, Mingqiang, LI, Shanpeng, Li, Yanjie, Li, Yilei, Li, Zhongxiao, Lingli, Lingli, Liu, Chao, Liu, Depei, Liu, Duo, Liu, Fang, Liu, Huilin, Liu, Jiaqiu, Liu, Jingchao, Liu, Yongmei, Liu, Yun, Long, Huajun, Lu, Yan, Luo, Guojin, Lv, Jun, Lv, Silu, Ma, Liangcai, Mao, Enke, McDonnell, John, Meng, Fanwen, Meng, Jinhuai, Millwood, Iona, Nie, Qunhua, Ning, Feng, Pan, Dongxia, Pan, Rong, Pang, Zengchang, Pei, Pei, Peto, Richard, Pozarickij, Alfred, Qian, Yijian, Qin, Yulu, Qu, Chan, Ren, Xiaolan, Ryder, Paul, Sansome, Sam, Schmidt, Dan, Sherliker, Paul, Sohoni, Rajani, Stevens, Becky, Su, Jian, Sun, Huarong, Sun, Qiang, Sun, Xiaohui, Tang, Aiyu, Tang, Zhenzhu, Tao, Ran, Tian, Xiaocao, Turnbull, Iain, Walters, Robin, Wan, Meng, Wang, Chunmei, Wang, Chen, Wang, Hao, Wang, Junzheng, Wang, Lin, Wang, Ping, Wang, Tao, Wang, Shaojie, Wang, Sisi, Wang, Xiaohuan, Wei, Liuping, Weng, Min, Wright, Neil, Wu, Ming, Wu, Xianping, Wu, Shukuan, Xie, Kaixu, Xu, Qiaohua, Xu, Qinai, Xu, Xin, Yan, Shichun, Yang, Ling, Yang, Xiaoming, Yang, Jie, Yao, Pang, Yin, Li, Yu, Bo, Yu, Canqing, Yu, Min, Zhai, Yaoming, Zhang, Hao, Zhang, Hui, Zhang, Jun, Zhang, Libo, Zhang, Ningmei, Zhang, Xi, Zhang, Xiaoyi, Zhang, Xukui, Zhong, Xunfu, Zhou, Ding Zhang, Zhou, Gang, Zhou, Jinyi, Zhou, Liyuan, Zhou, Weiwei, Zhou, Xue, Zhou, Yonglin, and Zou, Mingyuan
- Full Text
- View/download PDF
20. Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants With Treatment Resistance in Schizophrenia.
- Author
-
Pardiñas AF, Smart SE, Willcocks IR, Holmans PA, Dennison CA, Lynham AJ, Legge SE, Baune BT, Bigdeli TB, Cairns MJ, Corvin A, Fanous AH, Frank J, Kelly B, McQuillin A, Melle I, Mortensen PB, Mowry BJ, Pato CN, Periyasamy S, Rietschel M, Rujescu D, Simonsen C, St Clair D, Tooney P, Wu JQ, Andreassen OA, Kowalec K, Sullivan PF, Murray RM, Owen MJ, MacCabe JH, O'Donovan MC, Walters JTR, Ajnakina O, Alameda L, Barnes TRE, Berardi D, Bonora E, Camporesi S, Cleusix M, Conus P, Crespo-Facorro B, D'Andrea G, Demjaha A, Do KQ, Doody GA, Eap CB, Ferchiou A, Di Forti M, Guidi L, Homman L, Jenni R, Joyce EM, Kassoumeri L, Khadimallah I, Lastrina O, Muratori R, Noyan H, O'Neill FA, Pignon B, Restellini R, Richard JR, Schürhoff F, Španiel F, Szöke A, Tarricone I, Tortelli A, Üçok A, and Vázquez-Bourgon J
- Subjects
- Female, Genetic Predisposition to Disease genetics, Genome-Wide Association Study, Humans, Male, Multifactorial Inheritance genetics, Psychotic Disorders drug therapy, Schizophrenia diagnosis, Schizophrenia drug therapy, Schizophrenia genetics
- Abstract
Importance: About 20% to 30% of people with schizophrenia have psychotic symptoms that do not respond adequately to first-line antipsychotic treatment. This clinical presentation, chronic and highly disabling, is known as treatment-resistant schizophrenia (TRS). The causes of treatment resistance and their relationships with causes underlying schizophrenia are largely unknown. Adequately powered genetic studies of TRS are scarce because of the difficulty in collecting data from well-characterized TRS cohorts., Objective: To examine the genetic architecture of TRS through the reassessment of genetic data from schizophrenia studies and its validation in carefully ascertained clinical samples., Design, Setting, and Participants: Two case-control genome-wide association studies (GWASs) of schizophrenia were performed in which the case samples were defined as individuals with TRS (n = 10 501) and individuals with non-TRS (n = 20 325). The differences in effect sizes for allelic associations were then determined between both studies, the reasoning being such differences reflect treatment resistance instead of schizophrenia. Genotype data were retrieved from the CLOZUK and Psychiatric Genomics Consortium (PGC) schizophrenia studies. The output was validated using polygenic risk score (PRS) profiling of 2 independent schizophrenia cohorts with TRS and non-TRS: a prevalence sample with 817 individuals (Cardiff Cognition in Schizophrenia [CardiffCOGS]) and an incidence sample with 563 individuals (Genetics Workstream of the Schizophrenia Treatment Resistance and Therapeutic Advances [STRATA-G])., Main Outcomes and Measures: GWAS of treatment resistance in schizophrenia. The results of the GWAS were compared with complex polygenic traits through a genetic correlation approach and were used for PRS analysis on the independent validation cohorts using the same TRS definition., Results: The study included a total of 85 490 participants (48 635 [56.9%] male) in its GWAS stage and 1380 participants (859 [62.2%] male) in its PRS validation stage. Treatment resistance in schizophrenia emerged as a polygenic trait with detectable heritability (1% to 4%), and several traits related to intelligence and cognition were found to be genetically correlated with it (genetic correlation, 0.41-0.69). PRS analysis in the CardiffCOGS prevalence sample showed a positive association between TRS and a history of taking clozapine (r2 = 2.03%; P = .001), which was replicated in the STRATA-G incidence sample (r2 = 1.09%; P = .04)., Conclusions and Relevance: In this GWAS, common genetic variants were differentially associated with TRS, and these associations may have been obscured through the amalgamation of large GWAS samples in previous studies of broadly defined schizophrenia. Findings of this study suggest the validity of meta-analytic approaches for studies on patient outcomes, including treatment resistance.
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.