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A letter published in JAMA Psychiatry commends a systematic review on the prevalence of psychiatric comorbidities among people experiencing homelessness. However, caution is urged in interpreting the estimate that approximately one-fourth of people experiencing homelessness may have antisocial personality disorder (ASPD). The process of diagnosing ASPD and conduct disorder (CD) may involve value judgments that can contribute to misdiagnosis, particularly in the context of structural racism and the criminalization of homelessness. The letter emphasizes the need for comprehensive sociocultural context and more rigorous research in interpreting ASPD estimates among people experiencing homelessness. [Extracted from the article]