1. [Antigenicity study of T-3761].
- Author
-
Shibata T, Iwai N, Miyazaki M, Kawamura Y, and Kodama T
- Subjects
- Anaphylaxis, Animals, Anti-Infective Agents administration & dosage, Dogs, Guinea Pigs, Hemagglutination Tests, Immunoglobulin E analysis, Immunoglobulin E biosynthesis, Male, Mice, Mice, Inbred BALB C, Oxazines administration & dosage, Passive Cutaneous Anaphylaxis, Rats, Anti-Infective Agents immunology, Fluoroquinolones, Oxazines immunology
- Abstract
Antigenicity studies of T-3761, a new quinolone derivative, were conducted and the following results were obtained. 1. By active systemic anaphylaxis test in guinea pigs, neither immunogenicity nor allergenicity of T-3761 was noted. 2. By homologous 4-hour passive cutaneous anaphylaxis (PCA) test using the serum obtained from these guinea pigs, neither immunogenicity nor allergenicity of T-3761 was noted. 3. The potential of IgE antibody production in mice was examined by heterologous 24-hour PCA test in rats. But neither the potential of IgE antibody production nor allergenicity of T-3761 was noted. 4. By passive hemagglutination assay, we analysed the antibody titer in rats and dogs serum obtained from three-month toxicity repeated dose studies (oral and intravenously administration). But the hemagglutination response was negative and specific antibodies were not detected.
- Published
- 1995