1. Antimicrobial Resistance Patterns of Common Gram-Negative Microorganisms Isolated from Patients with Lower Respiratory Tract Infections in a Teaching Hospital in Vietnam.
- Author
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Le HH, Nguyen AV, Vu LH, Nguyen VTH, Pham HQ, Le HV, Nguyen ST, Le HT, Dinh HV, Le NV, Le TD, Le MN, Nguyen VH, Hoang KT, and Le HHL
- Subjects
- Humans, Middle Aged, Vietnam epidemiology, Cross-Sectional Studies, Adult, Male, Female, Aged, Young Adult, Adolescent, Child, Aged, 80 and over, Child, Preschool, Infant, Gram-Negative Bacteria drug effects, Gram-Negative Bacteria isolation & purification, Anti-Bacterial Agents pharmacology, Respiratory Tract Infections microbiology, Respiratory Tract Infections epidemiology, Gram-Negative Bacterial Infections microbiology, Gram-Negative Bacterial Infections epidemiology, Hospitals, Teaching, Microbial Sensitivity Tests, Drug Resistance, Bacterial
- Abstract
This cross-sectional study investigated the antimicrobial resistance (AMR) patterns of gram-negative pathogens isolated from 4,789 hospitalized patients with lower respiratory tract infections (LRTIs). Of the collected specimens, 1,325 (27.7%) tested positive for gram-negative bacteria. Acinetobacter baumannii (38.6%), Pseudomonas aeruginosa (33.5%), Klebsiella pneumoniae (18.7%), Escherichia coli (5.6%), and Klebsiella aerogenes (3.5%) were the most prevalent isolates. AMR analysis revealed high resistance rates (79.9%-100%) of A. baumannii isolates to multiple classes of antibiotics except amikacin, trimethoprim/sulfamethoxazole, and colistin. P. aeruginosa displayed low resistance to colistin (< 10%) but high resistance to other antibiotics. K. pneumoniae displayed high resistance rates of 90.0%-100.0% to most penicillins, whereas resistance rates were notably lower for colistin (7.1%) and amikacin (16.7%). K. aerogenes exhibited high resistance to various antibiotics and sensitivity to amikacin (95.1%), ampicillin (100.0%), and colistin (100.0%). E. coli isolates exhibited resistance to ampicillin (96.9%) and maximum sensitivity to several antibiotics. Our study identified significant AMR trends and highlighted the prevalence of multidrug-resistant strains (93.6% for K. aerogenes and 69.1%-92.4% for other isolates). These findings emphasize the urgent need for appropriate antibiotic management practices to combat AMR in gram-negative pathogens associated with LRTIs.
- Published
- 2024
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