1. 11C-Para-aminobenzoic acid PET imaging of S. aureus and MRSA infection in preclinical models and humans
- Author
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Ordonez, Alvaro A, Parker, Matthew FL, Miller, Robert J, Plyku, Donika, Ruiz-Bedoya, Camilo A, Tucker, Elizabeth W, Luu, Justin M, Dikeman, Dustin A, Lesniak, Wojciech G, Holt, Daniel P, Dannals, Robert F, Miller, Lloyd S, Rowe, Steven P, Wilson, David M, and Jain, Sanjay K
- Subjects
Clinical Research ,Infectious Diseases ,Emerging Infectious Diseases ,Antimicrobial Resistance ,Biomedical Imaging ,Bioengineering ,Aetiology ,2.2 Factors relating to the physical environment ,Infection ,4-Aminobenzoic Acid ,Adult ,Animals ,Carbon Radioisotopes ,Contrast Media ,Female ,Humans ,Male ,Methicillin-Resistant Staphylococcus aureus ,Positron-Emission Tomography ,Rabbits ,Rats ,Staphylococcal Infections ,Tissue Distribution ,Young Adult ,Bacterial infections ,Diagnostic imaging ,Infectious disease - Abstract
Tools for noninvasive detection of bacterial pathogens are needed but are not currently available for clinical use. We have previously shown that para-aminobenzoic acid (PABA) rapidly accumulates in a wide range of pathogenic bacteria, motivating the development of related PET radiotracers. In this study, 11C-PABA PET imaging was used to accurately detect and monitor infections due to pyogenic bacteria in multiple clinically relevant animal models. 11C-PABA PET imaging selectively detected infections in muscle, intervertebral discs, and methicillin-resistant Staphylococcus aureus-infected orthopedic implants. In what we believe to be first-in-human studies in healthy participants, 11C-PABA was safe, well-tolerated, and had a favorable biodistribution, with low background activity in the lungs, muscles, and brain. 11C-PABA has the potential for clinical translation to detect and localize a broad range of bacteria.
- Published
- 2022