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Stability of dispersed materials remains an important question in a wide variety of fields such as cosmetics, catalysis, food or energy and the environment. As stability is directly linked to the size of the dispersed colloids it is essential to assess the size distribution of colloidal suspensions. Nowadays, microfluidic-based approaches generate increasing interest as they represent flexible and fast measurements allowing high throughput experimentations. However, characterization of colloidal dispersions is usually performed by dynamic light scattering (DLS), that requires static measurements as well as significant volumes, that are not compatible with on-line analysis and microfluidics. Moreover, due to flow-induced decorrelation terms, DLS measurements in microfluidic channels are only accurate at very low shear rates.This work aimed at developing an on-line microfluidic device for dispersed materials characterization using DLS. The main challenges of this project were i) to adapt the microfabrication of the PDMS device in order to combine microchannels of hundreds of microns with a milli-fluidic cavity to perform the DLS measurements, and ii) to downsize the DLS set up. A PDMS microchip, consisting in a millimeter cavity for DLS measurements in parallel with a microchannel, was designed to perform the measurement on the sample without stopping the suspension flow during the microfluidic experiment. The cavity geometry was then optimized thanks to numerical simulation to ensure a good sweep efficiency and to downscale as much as possible without impairing the DLS signal.By adapting the microfabrication process, a PDMS microfluidic chip was designed allowing the size measurements of successive suspensions containing 100 and 12 ​nm diameter particles. This work is a first step towards the implementation of a new technological building block for online microfluidic characterization.© 2017 Elsevier Inc. All rights reserved.