1. Epidemiologic Features of Systemic Vasculitides in the Southeast Region of Brazil
- Author
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Jozelia Rêgo, Roger A. Levy, Gilda Aparecida Ferreira, Valquiria Garcia Dinis, Bruno Schau, Alexandre Wagner Silva de Souza, Ana Luisa Calich, Mittermayer Barreto Santiago, Joice Moraes F M Belem, Morgana Ohira Gazzeta, Manuella Lima Gomes Ochtrop, Ana Beatriz Santos Bacchiega, Ana Luisa Pedreira, Henrique de Ataíde Mariz, Ruben Horst Duque, Rosa Maria Rodrigues Pereira, Mariana O. Perez, Zoraida Sachetto, Célio Roberto Gonçalves, Fabrícia Fonseca Simil, and Leandro Lara do Prado
- Subjects
medicine.medical_specialty ,Adolescent ,business.industry ,Polyarteritis nodosa ,Granulomatosis with Polyangiitis ,Churg-Strauss Syndrome ,medicine.disease ,Dermatology ,Hospitals ,Giant cell arteritis ,Cross-Sectional Studies ,Rheumatology ,medicine ,Humans ,Outpatient clinic ,Child ,business ,Microscopic polyangiitis ,Vasculitis ,Granulomatosis with polyangiitis ,Cryoglobulinemic vasculitis ,Brazil ,Systemic vasculitis - Abstract
Background/objective The epidemiology of vasculitis is variable in different geographic areas, and this issue has not been approached in Brazil yet. The objective of this study was to assess the frequency of vasculitis in specialized centers in Brazil. Methods This cross-sectional study was performed in 9 vasculitis outpatient clinics from 6 different states mainly from the Southeast and the Northeast regions of Brazil between 2015 and 2017. Diagnosis and/or classification criteria for Behcet disease (BD), Takayasu arteritis (TA), giant cell arteritis (GCA), polyarteritis nodosa (PAN), granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), eosinophilic granulomatosis with polyangiitis (EGPA), and cryoglobulinemic vasculitis (CryoVas) were used to include patients with at least 6 months of follow-up in this hospital-based survey. Results A total of 1233 patients with systemic vasculitis were included from the Southeast region. Behcet disease was the most frequent vasculitis (35.0%) followed by TA (26.4%), GPA (16.2%), PAN (5.8%), GCA (5.8%), EGPA (4.3%), MPA (3.4%), and CryoVas (3.0%). Up to 7.8% of vasculitis patients had a juvenile onset, and the frequency of vasculitides found in children and adolescents was as follows: TA (52.6%), BD (24.7%), GPA (12.4%), and PAN (10.3%). No cases of EGPA, MPA, and CryoVas were diagnosed before the age of 18 years. As a comparator, 103 vasculitis patients were included in the Northeast of Brazil where TA was found in 36.9% and BD in 31.1% of vasculitis cases. No GCA cases were found in the Northeast part of Brazil. Conclusions Similar to the epidemiology of vasculitis in Asia, BD and TA are the most frequent vasculitis in Southeastern Brazilian referral centers.
- Published
- 2019