6 results on '"Allen, Naomi"'
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2. Selenium and Prostate Cancer: Analysis of Individual Participant Data From Fifteen Prospective Studies.
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Allen, Naomi E., Travis, Ruth C., Appleby, Paul N., Albanes, Demetrius, Barnett, Matt J., Black, Amanda, Bueno-de-Mesquita, H. Bas, Deschasaux, Mélanie, Galan, Pilar, Goodman, Gary E., Goodman, Phyllis J., Gunter, Marc J., Heliövaara, Markku, Helzlsouer, Kathy J., Henderson, Brian E., Hercberg, Serge, Knekt, Paul, Kolonel, Laurence N., Lasheras, Christina, and Linseisen, Jakob
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PHYSIOLOGICAL effects of selenium , *PROSTATE cancer risk factors , *LOGISTIC regression analysis , *DISEASE progression , *CONFIDENCE intervals , *BLOOD sampling , *SELENIUM analysis , *LONGITUDINAL method , *NAILS (Anatomy) , *PROBABILITY theory , *PROSTATE tumors , *RESEARCH funding , *RISK assessment , *SELENIUM , *TOES , *CASE-control method - Abstract
Background: Some observational studies suggest that a higher selenium status is associated with a lower risk of prostate cancer but have been generally too small to provide precise estimates of associations, particularly by disease stage and grade.Methods: Collaborating investigators from 15 prospective studies provided individual-participant records (from predominantly men of white European ancestry) on blood or toenail selenium concentrations and prostate cancer risk. Odds ratios of prostate cancer by selenium concentration were estimated using multivariable-adjusted conditional logistic regression. All statistical tests were two-sided.Results: Blood selenium was not associated with the risk of total prostate cancer (multivariable-adjusted odds ratio [OR] per 80 percentile increase = 1.01, 95% confidence interval [CI] = 0.83 to 1.23, based on 4527 case patients and 6021 control subjects). However, there was heterogeneity by disease aggressiveness (ie, advanced stage and/or prostate cancer death, Pheterogeneity = .01), with high blood selenium associated with a lower risk of aggressive disease (OR = 0.43, 95% CI = 0.21 to 0.87) but not with nonaggressive disease. Nail selenium was inversely associated with total prostate cancer (OR = 0.29, 95% CI = 0.22 to 0.40, Ptrend < .001, based on 1970 case patients and 2086 control subjects), including both nonaggressive (OR = 0.33, 95% CI = 0.22 to 0.50) and aggressive disease (OR = 0.18, 95% CI = 0.11 to 0.31, Pheterogeneity = .08).Conclusions: Nail, but not blood, selenium concentration is inversely associated with risk of total prostate cancer, possibly because nails are a more reliable marker of long-term selenium exposure. Both blood and nail selenium concentrations are associated with a reduced risk of aggressive disease, which warrants further investigation. [ABSTRACT FROM AUTHOR]- Published
- 2016
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3. Fruit and Vegetable Intake and Overall Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC)
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Boffetta, Paolo, primary, Couto, Elisabeth, additional, Wichmann, Janine, additional, Ferrari, Pietro, additional, Trichopoulos, Dimitrios, additional, Bueno-de-Mesquita, H. Bas, additional, van Duijnhoven, Fränzel J. B., additional, Büchner, Frederike L., additional, Key, Tim, additional, Boeing, Heiner, additional, Nöthlings, Ute, additional, Linseisen, Jakob, additional, Gonzalez, Carlos A., additional, Overvad, Kim, additional, Nielsen, Michael R. S., additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Morois, Sophie, additional, Lagiou, Pagona, additional, Naska, Androniki, additional, Benetou, Vassiliki, additional, Kaaks, Rudolf, additional, Rohrmann, Sabine, additional, Panico, Salvatore, additional, Sieri, Sabina, additional, Vineis, Paolo, additional, Palli, Domenico, additional, van Gils, Carla H., additional, Peeters, Petra H., additional, Lund, Eiliv, additional, Brustad, Magritt, additional, Engeset, Dagrun, additional, Huerta, José María, additional, Rodríguez, Laudina, additional, Sánchez, Maria-José, additional, Dorronsoro, Miren, additional, Barricarte, Aurelio, additional, Hallmans, Göran, additional, Johansson, Ingegerd, additional, Manjer, Jonas, additional, Sonestedt, Emily, additional, Allen, Naomi E., additional, Bingham, Sheila, additional, Khaw, Kay-Tee, additional, Slimani, Nadia, additional, Jenab, Mazda, additional, Mouw, Traci, additional, Norat, Teresa, additional, Riboli, Elio, additional, and Trichopoulou, Antonia, additional
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- 2010
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4. Body Size and Risk of Colon and Rectal Cancer in the European Prospective Investigation Into Cancer and Nutrition (EPIC)
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Pischon, Tobias, primary, Lahmann, Petra H., additional, Boeing, Heiner, additional, Friedenreich, Christine, additional, Norat, Teresa, additional, Tjønneland, Anne, additional, Halkjaer, Jytte, additional, Overvad, Kim, additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Guernec, Gregory, additional, Bergmann, Manuela M., additional, Linseisen, Jakob, additional, Becker, Nikolaus, additional, Trichopoulou, Antonia, additional, Trichopoulos, Dimitrios, additional, Sieri, Sabina, additional, Palli, Domenico, additional, Tumino, Rosario, additional, Vineis, Paolo, additional, Panico, Salvatore, additional, Peeters, Petra H. M., additional, Bueno-de-Mesquita, H. Bas, additional, Boshuizen, Hendriek C., additional, Van Guelpen, Bethany, additional, Palmqvist, Richard, additional, Berglund, Göran, additional, Gonzalez, Carlos Alberto, additional, Dorronsoro, Miren, additional, Barricarte, Aurelio, additional, Navarro, Carmen, additional, Martinez, Carmen, additional, Quirós, J. Ramón, additional, Roddam, Andrew, additional, Allen, Naomi, additional, Bingham, Sheila, additional, Khaw, Kay-Tee, additional, Ferrari, Pietro, additional, Kaaks, Rudolf, additional, Slimani, Nadia, additional, and Riboli, Elio, additional
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- 2006
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5. Meat Intake and Risk of Stomach and Esophageal Adenocarcinoma Within the European Prospective Investigation Into Cancer and Nutrition (EPIC)
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González, Carlos A., primary, Jakszyn, Paula, additional, Pera, Guillem, additional, Agudo, Antonio, additional, Bingham, Sheila, additional, Palli, Domenico, additional, Ferrari, Pietro, additional, Boeing, Heiner, additional, del Giudice, Giuseppe, additional, Plebani, Mario, additional, Carneiro, Fátima, additional, Nesi, Gabriella, additional, Berrino, Franco, additional, Sacerdote, Carlotta, additional, Tumino, Rosario, additional, Panico, Salvatore, additional, Berglund, Göran, additional, Simán, Henrik, additional, Nyrén, Olof, additional, Hallmans, Göran, additional, Martinez, Carmen, additional, Dorronsoro, Miren, additional, Barricarte, Aurelio, additional, Navarro, Carmen, additional, Quirós, José R., additional, Allen, Naomi, additional, Key, Timothy J., additional, Day, Nicholas E., additional, Linseisen, Jakob, additional, Nagel, Gabriele, additional, Bergmann, Manuela M., additional, Overvad, Kim, additional, Jensen, Majken K., additional, Tjonneland, Anne, additional, Olsen, Anja, additional, Bueno-de-Mesquita, H. Bas, additional, Ocke, Marga, additional, Peeters, Petra H. M., additional, Numans, Mattijs E., additional, Clavel-Chapelon, Françoise, additional, Boutron-Ruault, Marie-Christine, additional, Trichopoulou, Antonia, additional, Psaltopoulou, Theodora, additional, Roukos, Dimitrios, additional, Lund, Eiliv, additional, Hemon, Bertrand, additional, Kaaks, Rudolf, additional, Norat, Teresa, additional, and Riboli, Elio, additional
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- 2006
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6. Moderate Alcohol Intake and Cancer Incidence in Women.
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Allen, Naomi E., Beral, Valerie, Casabonne, Delphine, Sau Wan Kan, Reeves, Gillian K., Brown, Anna, and Green, Jane
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CANCER in women , *BREAST cancer , *PHARYNGEAL cancer , *THYROID cancer , *ALCOHOL drinking , *SMOKING , *HODGKIN'S disease - Abstract
Background With the exception of breast cancer, little is known about the effect of moderate intakes of alcohol, or of particular types of alcohol, on cancer risk in women. Methods A total of 1280296 middle-aged women in the United Kingdom enrolled in the Million Women Study were routinely followed for incident cancer. Cox regression models were used to calculate adjusted relative risks and 95% confidence intervals (CIs) for 21 site-specific cancers according to amount and type of alcoholic beverage consumed. All statistical tests were two-sided. Results A quarter of the cohort reported drinking no alcohol; 98% of drinkers consumed fewer than 21 drinks per week, with drinkers consuming an average of 10 g alcohol (1 drink) per day. During an average 7.2 years of follow-up per woman 68775 invasive cancers occurred. Increasing alcohol consumption was associated with increased risks of cancers of the oral cavity and pharynx (increase per 10 g/d = 29%, 95% Cl = 14% to 45%, Ptrend <.001), esophagus (22%, 95% CI = 8% to 38%, Ptrend, = .002), larynx (44%, 95% Cl = 10% to 88%, Ptrend = .008), rectum (10%, 95% CI = 2% to 18%, Ptrend = .02), liver (24%, 95% Cl = 2% to 51%, Ptrend = .03), breast (12%, 95% Cl = 9% to 14%, Ptrend <.001), and total cancer (6%, 95% Cl = 4% to 7%, Ptrend < .001). The trends were similar in women who drank wine exclusively and other consumers of alcohol. For cancers of the upper aerodigestive tract, the alcohol-associated risk was confined to current smokers, with little or no effect of alcohol among never and past smokers (Pheterogeneity < .001). Increasing levels of alcohol consumption were associated with a decreased risk of thyroid cancer (Ptrend =.005), non-Hodgkin lymphoma (Ptrend =.001), and renal cell carcinoma (Ptrend=.03) Conclusions Low to moderate alcohol consumption in women increases the risk of certain cancers. For every additional drink regularly consumed per day, the increase in incidence up to age 75 years per 1000 for women in developed countries is estimated to be about 11 for breast cancer, 1 for cancers of the oral cavity and pharynx, 1 for cancer of the rectum, and 0.7 each for cancers of the esophagus, larynx and liver, giving a total excess of about 15 cancers per 1000 women up to age 75. [ABSTRACT FROM AUTHOR]
- Published
- 2009
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