37 results on '"Freedman, Neal D."'
Search Results
2. Trends in smoking-attributable and smoking-unrelated lung cancer death rates in the United States, 1991-2018.
- Author
-
Shiels, Meredith S, Graubard, Barry I, McNeel, Timothy S, Kahle, Lisa, and Freedman, Neal D
- Subjects
LUNG cancer ,DEATH rate ,PASSIVE smoking ,AIR pollution ,SMOKING - Abstract
Background In the United States, lung cancer death rates have been declining for decades, primarily as a result of pronounced decreases in cigarette smoking. It is unclear, however, whether there have been similar declines in mortality rates of lung cancer unrelated to smoking. We estimated trends in US lung cancer death rates attributable and not attributable to smoking from 1991 to 2018. Methods The study included 30- to 79-year-olds in the National Health Interview Survey who were linked to the National Death Index, 1991-2014. Adjusted hazard ratios for smoking status and lung cancer death were estimated, and age-specific population attributable fractions were calculated. Annual population attributable fractions were multiplied by annual US national lung cancer mortality, partitioning rates into smoking-attributable and smoking-unrelated lung cancer deaths. All statistical tests were 2-sided. Results During 1991-2018, the proportion of never smokers increased among both men (35.1%-54.6%) and women (54.0%-65.4%). Compared with those who had ever smoked, those who had never smoked had 86% lower risk (hazard ratio = 0.14; 95% confidence interval [CI] = 0.12 to 0.16) of lung cancer death. The fraction of lung cancer deaths attributable to smoking decreased from 81.4% (95% CI = 78.9 to 81.4) to 74.7% (95% CI = 78.1 to 71.4). Smoking-attributable lung cancer death rates declined 2.7% per year (95% CI = ‒2.9% to ‒2.5%) and smoking-unrelated lung cancer death rates declined 1.8% per year (95% CI = ‒2.0% to ‒1.5%); these declines have accelerated in recent years. Conclusions An increasing proportion of lung cancer deaths are unrelated to smoking based on declines in smoking prevalence. Smoking-unrelated lung cancer death rates have declined, however, perhaps because of decreases in secondhand smoke and air pollution exposure as well as treatment improvements. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Trends in smoking-attributable and smoking-unrelated lung cancer death rates in the U.S., 1991-2018
- Author
-
Shiels, Meredith S, primary, Graubard, Barry I, additional, McNeel, Timothy S, additional, Kahle, Lisa, additional, and Freedman, Neal D, additional
- Published
- 2023
- Full Text
- View/download PDF
4. Exposure to polycyclic aromatic hydrocarbons, volatile organic compounds, and tobacco-specific nitrosamines and incidence of esophageal cancer
- Author
-
Etemadi, Arash, primary, Poustchi, Hossein, additional, Chang, Cindy M, additional, Calafat, Antonia M, additional, Blount, Benjamin C, additional, Bhandari, Deepak, additional, Wang, Lanqing, additional, Roshandel, Gholamreza, additional, Alexandridis, Apostolos, additional, Botelho, Julianne Cook, additional, Xia, Baoyun, additional, Wang, Yuesong, additional, Sosnoff, Connie S, additional, Feng, Jun, additional, Nalini, Mahdi, additional, Khoshnia, Masoud, additional, Pourshams, Akram, additional, Sotoudeh, Masoud, additional, Gail, Mitchell H, additional, Dawsey, Sanford M, additional, Kamangar, Farin, additional, Boffetta, Paolo, additional, Brennan, Paul, additional, Abnet, Christian C, additional, Malekzadeh, Reza, additional, and Freedman, Neal D, additional
- Published
- 2023
- Full Text
- View/download PDF
5. Ambient fine particulate matter and breast cancer incidence in a large prospective US cohort.
- Author
-
White, Alexandra J, Fisher, Jared A, Sweeney, Marina R, Freedman, Neal D, Kaufman, Joel D, Silverman, Debra T, and Jones, Rena R
- Subjects
PARTICULATE matter ,BREAST cancer ,WATERSHEDS ,AIR pollutants ,ESTROGEN receptors ,HORMONE receptor positive breast cancer - Abstract
Background Fine particulate matter (PM
2.5 ) has been inconsistently associated with breast cancer incidence, however, few studies have considered historic exposure when levels were higher. Methods Outdoor residential PM2.5 concentrations were estimated using a nationwide spatiotemporal model for women in the National Institutes of Health–AARP Diet and Health Study, a prospective cohort located in 6 states (California, Florida, Louisiana, New Jersey, North Carolina, and Pennsylvania) and 2 metropolitan areas (Atlanta, GA, and Detroit, MI) and enrolled in 1995-1996 (n = 196 905). Annual average PM2.5 concentrations were estimated for a 5-year historical period 10 years prior to enrollment (1980-1984). We used Cox regression to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between a 10 µg/m3 increase in PM2.5 and breast cancer incidence overall and by estrogen receptor status and catchment area. Results With follow-up of participants through 2017, a total of 15 870 breast cancer cases were identified. A 10 ug/m3 increase in PM2.5 was statistically significantly associated with overall breast cancer incidence (HR = 1.08, 95% CI = 1.02 to 1.13). The association was evident for estrogen receptor–positive (HR = 1.10, 95% CI = 1.04 to 1.17) but not estrogen receptor–negative tumors (HR = 0.97, 95% CI = 0.84 to 1.13; Pheterogeneity = .3). Overall breast cancer hazard ratios were more than 1 across the catchment areas, ranging from a hazard ratio of 1.26 (95% CI = 0.96 to 1.64) for North Carolina to a hazard ratio of 1.04 (95% CI = 0.68 to 1.57) for Louisiana (Pheterogeneity = .9). Conclusions In this large US cohort with historical air pollutant exposure estimates, PM2.5 was associated with risk of estrogen receptor–positive breast cancer. State-specific estimates were imprecise but suggest that future work should consider region-specific associations and the potential contribution of PM2.5 chemical constituency in modifying the observed association. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
6. Ambient fine particulate matter and breast cancer incidence in a large prospective US cohort
- Author
-
White, Alexandra J, primary, Fisher, Jared A, additional, Sweeney, Marina R, additional, Freedman, Neal D, additional, Kaufman, Joel D, additional, Silverman, Debra T, additional, and Jones, Rena R, additional
- Published
- 2023
- Full Text
- View/download PDF
7. Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools
- Author
-
Feng, Xiaoshuang, primary, Wu, Wendy Yi-Ying, additional, Onwuka, Justina Ucheojor, additional, Haider, Zahra, additional, Alcala, Karine, additional, Smith-Byrne, Karl, additional, Zahed, Hana, additional, Guida, Florence, additional, Wang, Renwei, additional, Bassett, Julie K, additional, Stevens, Victoria, additional, Wang, Ying, additional, Weinstein, Stephanie, additional, Freedman, Neal D, additional, Chen, Chu, additional, Tinker, Lesley, additional, Nøst, Therese Haugdahl, additional, Koh, Woon-Puay, additional, Muller, David, additional, Colorado-Yohar, Sandra M, additional, Tumino, Rosario, additional, Hung, Rayjean J, additional, Amos, Christopher I, additional, Lin, Xihong, additional, Zhang, Xuehong, additional, Arslan, Alan A, additional, Sánchez, Maria-Jose, additional, Sørgjerd, Elin Pettersen, additional, Severi, Gianluca, additional, Hveem, Kristian, additional, Brennan, Paul, additional, Langhammer, Arnulf, additional, Milne, Roger L, additional, Yuan, Jian-Min, additional, Melin, Beatrice, additional, Johansson, Mikael, additional, Robbins, Hilary A, additional, and Johansson, Mattias, additional
- Published
- 2023
- Full Text
- View/download PDF
8. Cancer mortality rates by racial/ethnic groups in the United States, 2018–2020
- Author
-
Haque, Anika T, primary, Berrington de González, Amy, additional, Chen, Yingxi, additional, Haozous, Emily A, additional, Inoue-Choi, Maki, additional, Lawrence, Wayne R, additional, McGee-Avila, Jennifer K, additional, Nápoles, Anna M, additional, Pérez-Stable, Eliseo J, additional, Taparra, Kekoa, additional, Vo, Jacqueline B, additional, Freedman, Neal D, additional, and Shiels, Meredith S, additional
- Published
- 2023
- Full Text
- View/download PDF
9. Cancer mortality rates by racial and ethnic groups in the United States, 2018-2020.
- Author
-
Haque, Anika T, González, Amy Berrington de, Chen, Yingxi, Haozous, Emily A, Inoue-Choi, Maki, Lawrence, Wayne R, McGee-Avila, Jennifer K, Nápoles, Anna M, Pérez-Stable, Eliseo J, Taparra, Kekoa, Vo, Jacqueline B, Freedman, Neal D, and Shiels, Meredith S
- Subjects
CANCER-related mortality ,ETHNIC groups ,ASIANS ,DEATH rate ,RACIAL classification - Abstract
Background Starting in 2018, national death certificates included a new racial classification system that accounts for multiple-race decedents and separates Native Hawaiian and Pacific Islander (NHPI) individuals from Asian individuals. We estimated cancer death rates across updated racial and ethnic categories, sex, and age. Methods Age-standardized US cancer mortality rates and rate ratios from 2018 to 2020 among individuals aged 20 years and older were estimated with national death certificate data by race and ethnicity, sex, age, and cancer site. Results In 2018, there were approximately 597 000 cancer deaths, 598 000 in 2019, and 601 000 in 2020. Among men, cancer death rates were highest in Black men (298.2 per 100 000; n = 105 632), followed by White (250.8; n = 736 319), American Indian/Alaska Native (AI/AN; 249.2; n = 3376), NHPI (205.6; n = 1080), Latino (177.2; n = 66 167), and Asian (147.9; n = 26 591) men. Among women, Black women had the highest cancer death rates (206.5 per 100 000; n = 104 437), followed by NHPI (192.1; n = 1141), AI/AN (189.9; n = 3239), White (183.0; n = 646 865), Latina (128.4; n = 61 579), and Asian (111.4; n = 26 396) women. The highest death rates by age group occurred among NHPI individuals aged 20-49 years and Black individuals aged 50-69 and 70 years and older. Asian individuals had the lowest cancer death rates across age groups. Compared with Asian individuals, total cancer death rates were 39% higher in NHPI men and 73% higher in NHPI women. Conclusions There were striking racial and ethnic disparities in cancer death rates during 2018-2020. Separating NHPI and Asian individuals revealed large differences in cancer mortality between 2 groups that were previously combined in vital statistics data. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
10. The Oral Microbiome and Lung Cancer Risk: An Analysis of 3 Prospective Cohort Studies
- Author
-
Vogtmann, Emily, primary, Hua, Xing, additional, Yu, Guoqin, additional, Purandare, Vaishnavi, additional, Hullings, Autumn G, additional, Shao, Dantong, additional, Wan, Yunhu, additional, Li, Shilan, additional, Dagnall, Casey L, additional, Jones, Kristine, additional, Hicks, Belynda D, additional, Hutchinson, Amy, additional, Caporaso, J Gregory, additional, Wheeler, William, additional, Sandler, Dale P, additional, Beane Freeman, Laura E, additional, Liao, Linda M, additional, Huang, Wen-Yi, additional, Freedman, Neal D, additional, Caporaso, Neil E, additional, Sinha, Rashmi, additional, Gail, Mitchell H, additional, Shi, Jianxin, additional, and Abnet, Christian C, additional
- Published
- 2022
- Full Text
- View/download PDF
11. Development and Validation of a Risk Prediction Model for Second Primary Lung Cancer
- Author
-
Choi, Eunji, primary, Sanyal, Nilotpal, additional, Ding, Victoria Y, additional, Gardner, Rebecca M, additional, Aredo, Jacqueline V, additional, Lee, Justin, additional, Wu, Julie T, additional, Hickey, Thomas P, additional, Barrett, Brian, additional, Riley, Thomas L, additional, Wilkens, Lynne R, additional, Leung, Ann N, additional, Le Marchand, Loïc, additional, Tammemägi, Martin C, additional, Hung, Rayjean J, additional, Amos, Christopher I, additional, Freedman, Neal D, additional, Cheng, Iona, additional, Wakelee, Heather A, additional, and Han, Summer S, additional
- Published
- 2021
- Full Text
- View/download PDF
12. Novel Biomarkers of Habitual Alcohol Intake and Associations With Risk of Pancreatic and Liver Cancers and Liver Disease Mortality
- Author
-
Loftfield, Erikka, primary, Stepien, Magdalena, additional, Viallon, Vivian, additional, Trijsburg, Laura, additional, Rothwell, Joseph A, additional, Robinot, Nivonirina, additional, Biessy, Carine, additional, Bergdahl, Ingvar A, additional, Bodén, Stina, additional, Schulze, Matthias B, additional, Bergman, Manuela, additional, Weiderpass, Elisabete, additional, Schmidt, Julie A, additional, Zamora-Ros, Raul, additional, Nøst, Therese H, additional, Sandanger, Torkjel M, additional, Sonestedt, Emily, additional, Ohlsson, Bodil, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Ricceri, Fulvio, additional, Tjønneland, Anne, additional, Dahm, Christina C, additional, Sánchez, Maria-Jose, additional, Trichopoulou, Antonia, additional, Tumino, Rosario, additional, Chirlaque, María-Dolores, additional, Masala, Giovanna, additional, Ardanaz, Eva, additional, Vermeulen, Roel, additional, Brennan, Paul, additional, Albanes, Demetrius, additional, Weinstein, Stephanie J, additional, Scalbert, Augustin, additional, Freedman, Neal D, additional, Gunter, Marc J, additional, Jenab, Mazda, additional, Sinha, Rashmi, additional, Keski-Rahkonen, Pekka, additional, and Ferrari, Pietro, additional
- Published
- 2021
- Full Text
- View/download PDF
13. Development and Validation of a Risk Prediction Model for Second Primary Lung Cancer.
- Author
-
Choi, Eunji, Sanyal, Nilotpal, Ding, Victoria Y, Gardner, Rebecca M, Aredo, Jacqueline V, Lee, Justin, Wu, Julie T, Hickey, Thomas P, Barrett, Brian, Riley, Thomas L, Wilkens, Lynne R, Leung, Ann N, Marchand, Loïc Le, Tammemägi, Martin C, Hung, Rayjean J, Amos, Christopher I, Freedman, Neal D, Cheng, Iona, Wakelee, Heather A, and Han, Summer S
- Subjects
LUNG cancer ,PREDICTION models ,RECEIVER operating characteristic curves ,DECISION making ,EARLY detection of cancer ,LUNGS ,LUNG tumors ,SECONDARY primary cancer ,SMOKING - Abstract
Background: With advancing therapeutics, lung cancer (LC) survivors are rapidly increasing in number. Although mounting evidence suggests LC survivors have high risk of second primary lung cancer (SPLC), there is no validated prediction model available for clinical use to identify high-risk LC survivors for SPLC.Methods: Using data from 6325 ever-smokers in the Multiethnic Cohort (MEC) study diagnosed with initial primary lung cancer (IPLC) in 1993-2017, we developed a prediction model for 10-year SPLC risk after IPLC diagnosis using cause-specific Cox regression. We evaluated the model's clinical utility using decision curve analysis and externally validated it using 2 population-based data-Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) and National Lung Screening Trial (NLST)-that included 2963 and 2844 IPLC (101 and 93 SPLC cases), respectively.Results: Over 14 063 person-years, 145 (2.3%) ever-smoking IPLC patients developed SPLC in MEC. Our prediction model demonstrated a high predictive accuracy (Brier score = 2.9, 95% confidence interval [CI] = 2.4 to 3.3) and discrimination (area under the receiver operating characteristics [AUC] = 81.9%, 95% CI = 78.2% to 85.5%) based on bootstrap validation in MEC. Stratification by the estimated risk quartiles showed that the observed SPLC incidence was statistically significantly higher in the 4th vs 1st quartile (9.5% vs 0.2%; P < .001). Decision curve analysis indicated that in a wide range of 10-year risk thresholds from 1% to 20%, the model yielded a larger net-benefit vs hypothetical all-screening or no-screening scenarios. External validation using PLCO and NLST showed an AUC of 78.8% (95% CI = 74.6% to 82.9%) and 72.7% (95% CI = 67.7% to 77.7%), respectively.Conclusions: We developed and validated a SPLC prediction model based on large population-based cohorts. The proposed prediction model can help identify high-risk LC patients for SPLC and can be incorporated into clinical decision making for SPLC surveillance and screening. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
14. Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma
- Author
-
Shearer, Joseph J, primary, Callahan, Catherine L, additional, Calafat, Antonia M, additional, Huang, Wen-Yi, additional, Jones, Rena R, additional, Sabbisetti, Venkata S, additional, Freedman, Neal D, additional, Sampson, Joshua N, additional, Silverman, Debra T, additional, Purdue, Mark P, additional, and Hofmann, Jonathan N, additional
- Published
- 2020
- Full Text
- View/download PDF
15. Serum Concentrations of Per- and Polyfluoroalkyl Substances and Risk of Renal Cell Carcinoma.
- Author
-
Shearer, Joseph J, Callahan, Catherine L, Calafat, Antonia M, Huang, Wen-Yi, Jones, Rena R, Sabbisetti, Venkata S, Freedman, Neal D, Sampson, Joshua N, Silverman, Debra T, Purdue, Mark P, and Hofmann, Jonathan N
- Subjects
PERSISTENT pollutants ,RENAL cancer ,PERFLUOROOCTANOIC acid ,KIDNEY physiology ,CARCINOGENS ,RENAL cell carcinoma ,RESEARCH ,POLLUTANTS ,RESEARCH methodology ,EVALUATION research ,FLUOROCARBONS ,COMPARATIVE studies ,KIDNEY tumors ,RESEARCH funding ,SULFUR acids - Abstract
Background: Per- and polyfluoroalkyl substances (PFAS) are highly persistent chemicals that have been detected in the serum of over 98% of the US population. Studies among highly exposed individuals suggest an association with perfluorooctanoic acid (PFOA) exposure and kidney cancer. It remains unclear whether PFOA or other PFAS are renal carcinogens or if they influence risk of renal cell carcinoma (RCC) at concentrations observed in the general population.Methods: We measured prediagnostic serum concentrations of PFOA and 7 additional PFAS in 324 RCC cases and 324 individually matched controls within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Multivariable conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CIs) relating serum PFAS concentrations and RCC risk. Individual PFAS were modeled continuously (log2-transformed) and categorically, with adjustment for kidney function and additional potential confounders. All statistical tests were 2-sided.Results: We observed a positive association with RCC risk for PFOA (doubling in serum concentration, ORcontinuous = 1.71, 95% CI = 1.23 to 2.37, P = .002) and a greater than twofold increased risk among those in the highest quartile vs the lowest (OR = 2.63, 95% CI = 1.33 to 5.20, Ptrend = .007). The association with PFOA was similar after adjustment for other PFAS (ORcontinuous = 1.68, 95% CI = 1.07 to 2.63, P = .02) and remained apparent in analyses restricted to individuals without evidence of diminished kidney function and in cases diagnosed 8 or more years after phlebotomy.Conclusions: Our findings add substantially to the weight of evidence that PFOA is a renal carcinogen and may have important public health implications for the many individuals exposed to this ubiquitous and highly persistent chemical. [ABSTRACT FROM AUTHOR]- Published
- 2021
- Full Text
- View/download PDF
16. Trends in Mortality Due to Cancer in the United States by Age and County-Level Income, 1999–2015
- Author
-
Withrow, Diana R, primary, Berrington de González, Amy, additional, Spillane, Susan, additional, Freedman, Neal D, additional, Best, Ana F, additional, Chen, Yingxi, additional, and Shiels, Meredith S, additional
- Published
- 2019
- Full Text
- View/download PDF
17. Prospective Investigation of Serum Metabolites, Coffee Drinking, Liver Cancer Incidence, and Liver Disease Mortality
- Author
-
Loftfield, Erikka, primary, Rothwell, Joseph A, primary, Sinha, Rashmi, primary, Keski-Rahkonen, Pekka, primary, Robinot, Nivonirina, primary, Albanes, Demetrius, primary, Weinstein, Stephanie J, primary, Derkach, Andriy, primary, Sampson, Joshua, primary, Scalbert, Augustin, primary, and Freedman, Neal D, primary
- Published
- 2019
- Full Text
- View/download PDF
18. Smoking, Alcohol, and Biliary Tract Cancer Risk: A Pooling Project of 26 Prospective Studies
- Author
-
McGee, Emma E, primary, Jackson, Sarah S, additional, Petrick, Jessica L, additional, Van Dyke, Alison L, additional, Adami, Hans-Olov, additional, Albanes, Demetrius, additional, Andreotti, Gabriella, additional, Beane-Freeman, Laura E, additional, Berrington de Gonzalez, Amy, additional, Buring, Julie E, additional, Chan, Andrew T, additional, Chen, Yu, additional, Fraser, Gary E, additional, Freedman, Neal D, additional, Gao, Yu-Tang, additional, Gapstur, Susan M, additional, Gaziano, J Michael, additional, Giles, Graham G, additional, Grant, Eric J, additional, Grodstein, Francine, additional, Hartge, Patricia, additional, Jenab, Mazda, additional, Kitahara, Cari M, additional, Knutsen, Synnove F, additional, Koh, Woon-Puay, additional, Larsson, Susanna C, additional, Lee, I-Min, additional, Liao, Linda M, additional, Luo, Juhua, additional, Milne, Roger L, additional, Monroe, Kristine R, additional, Neuhouser, Marian L, additional, O’Brien, Katie M, additional, Peters, Ulrike, additional, Poynter, Jenny N, additional, Purdue, Mark P, additional, Robien, Kim, additional, Sandler, Dale P, additional, Sawada, Norie, additional, Schairer, Catherine, additional, Sesso, Howard D, additional, Simon, Tracey G, additional, Sinha, Rashmi, additional, Stolzenberg-Solomon, Rachael, additional, Tsugane, Shoichiro, additional, Wang, Renwei, additional, Weiderpass, Elisabete, additional, Weinstein, Stephanie J, additional, White, Emily, additional, Wolk, Alicja, additional, Yuan, Jian-Min, additional, Zeleniuch-Jacquotte, Anne, additional, Zhang, Xuehong, additional, Zhu, Bin, additional, McGlynn, Katherine A, additional, Campbell, Peter T, additional, and Koshiol, Jill, additional
- Published
- 2019
- Full Text
- View/download PDF
19. Prospective Investigation of Serum Metabolites, Coffee Drinking, Liver Cancer Incidence, and Liver Disease Mortality.
- Author
-
Loftfield, Erikka, Rothwell, Joseph A, Sinha, Rashmi, Keski-Rahkonen, Pekka, Robinot, Nivonirina, Albanes, Demetrius, Weinstein, Stephanie J, Derkach, Andriy, Sampson, Joshua, Scalbert, Augustin, and Freedman, Neal D
- Subjects
LIVER cancer ,LIVER diseases ,COFFEE drinking ,METABOLITES ,LIVER disease etiology ,LIVER tumors ,COFFEE ,STEROIDS ,ALKALOIDS ,DISEASE incidence ,CASE-control method ,REGRESSION analysis ,RESEARCH funding ,LONGITUDINAL method - Abstract
Background: Coffee has been consistently associated with lower risk of liver cancer and chronic liver disease, suggesting that coffee affects mechanisms underlying disease development.Methods: We measured serum metabolites using untargeted metabolomics in 1:1 matched nested case-control studies of liver cancer (n = 221 cases) and fatal liver disease (n = 242 cases) in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention cohort (n = 29 133). Associations between baseline coffee drinking and metabolites were identified using linear regression; conditional logistic regression models were used to identify associations with subsequent outcomes.Results: Overall, 21 metabolites were associated with coffee drinking and also each subsequent endpoint; nine metabolites and trigonelline, a known coffee biomarker, were identified. Tyrosine and two bile acids, glycochenodeoxycholic acid (GCDCA) and glycocholic acid (GCA), were inversely associated with coffee but positively associated with both outcomes; odds ratios (ORs) comparing the 90th to 10th percentile (modeled on a continuous basis) ranged from 3.93 (95% confidence interval [CI] = 2.00 to 7.74) for tyrosine to 4.95 (95% CI = 2.64 to 9.29) for GCA and from 4.00 (95% CI = 2.42 to 6.62) for GCA to 6.77 (95% CI = 3.62 to 12.65) for GCDCA for liver cancer and fatal liver disease, respectively. The remaining six metabolites and trigonelline were positively associated with coffee drinking but inversely associated with both outcomes; odds ratio ranged from 0.16 to 0.37. Associations persisted following diet adjustment and for outcomes occurring greater than 10 years after blood collection.Conclusions: A broad range of compounds were associated with coffee drinking, incident liver cancer, and liver disease death over 27 years of follow-up. These associations provide novel insight into chronic liver disease and liver cancer etiology and support a possible hepatoprotective effect of coffee. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
20. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts
- Author
-
McCullough, Marjorie L, primary, Zoltick, Emilie S, additional, Weinstein, Stephanie J, additional, Fedirko, Veronika, additional, Wang, Molin, additional, Cook, Nancy R, additional, Eliassen, A Heather, additional, Zeleniuch-Jacquotte, Anne, additional, Agnoli, Claudia, additional, Albanes, Demetrius, additional, Barnett, Matthew J, additional, Buring, Julie E, additional, Campbell, Peter T, additional, Clendenen, Tess V, additional, Freedman, Neal D, additional, Gapstur, Susan M, additional, Giovannucci, Edward L, additional, Goodman, Gary G, additional, Haiman, Christopher A, additional, Ho, Gloria Y F, additional, Horst, Ronald L, additional, Hou, Tao, additional, Huang, Wen-Yi, additional, Jenab, Mazda, additional, Jones, Michael E, additional, Joshu, Corinne E, additional, Krogh, Vittorio, additional, Lee, I-Min, additional, Lee, Jung Eun, additional, Männistö, Satu, additional, Le Marchand, Loic, additional, Mondul, Alison M, additional, Neuhouser, Marian L, additional, Platz, Elizabeth A, additional, Purdue, Mark P, additional, Riboli, Elio, additional, Robsahm, Trude Eid, additional, Rohan, Thomas E, additional, Sasazuki, Shizuka, additional, Schoemaker, Minouk J, additional, Sieri, Sabina, additional, Stampfer, Meir J, additional, Swerdlow, Anthony J, additional, Thomson, Cynthia A, additional, Tretli, Steinar, additional, Tsugane, Schoichiro, additional, Ursin, Giske, additional, Visvanathan, Kala, additional, White, Kami K, additional, Wu, Kana, additional, Yaun, Shiaw-Shyuan, additional, Zhang, Xuehong, additional, Willett, Walter C, additional, Gail, Mitchel H, additional, Ziegler, Regina G, additional, and Smith-Warner, Stephanie A, additional
- Published
- 2018
- Full Text
- View/download PDF
21. Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men
- Author
-
Petrick, Jessica L, primary, Hyland, Paula L, additional, Caron, Patrick, additional, Falk, Roni T, additional, Pfeiffer, Ruth M, additional, Dawsey, Sanford M, additional, Abnet, Christian C, additional, Taylor, Philip R, additional, Weinstein, Stephanie J, additional, Albanes, Demetrius, additional, Freedman, Neal D, additional, Gapstur, Susan M, additional, Bradwin, Gary, additional, Guillemette, Chantal, additional, Campbell, Peter T, additional, and Cook, Michael B, additional
- Published
- 2018
- Full Text
- View/download PDF
22. Kinetics of the Human Papillomavirus Type 16 E6 Antibody Response Prior to Oropharyngeal Cancer
- Author
-
Kreimer, Aimée R., primary, Johansson, Mattias, additional, Yanik, Elizabeth L., additional, Katki, Hormuzd A., additional, Check, David P., additional, Lang Kuhs, Krystle A., additional, Willhauck-Fleckenstein, Martina, additional, Holzinger, Dana, additional, Hildesheim, Allan, additional, Pfeiffer, Ruth, additional, Williams, Craig, additional, Freedman, Neal D., additional, Huang, Wen-Yi, additional, Purdue, Mark P., additional, Michel, Angelika, additional, Pawlita, Michael, additional, Brennan, Paul, additional, and Waterboer, Tim, additional
- Published
- 2017
- Full Text
- View/download PDF
23. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts.
- Author
-
McCullough, Marjorie L, Zoltick, Emilie S, Weinstein, Stephanie J, Fedirko, Veronika, Wang, Molin, Cook, Nancy R, Eliassen, A Heather, Zeleniuch-Jacquotte, Anne, Agnoli, Claudia, Albanes, Demetrius, Barnett, Matthew J, Buring, Julie E, Campbell, Peter T, Clendenen, Tess V, Freedman, Neal D, Gapstur, Susan M, Giovannucci, Edward L, Goodman, Gary G, Haiman, Christopher A, and Ho, Gloria Y F
- Abstract
Background: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize risk are unknown. Current Institute of Medicine (IOM) vitamin D guidance is based solely on bone health.Methods: We pooled participant-level data from 17 cohorts, comprising 5706 colorectal cancer case participants and 7107 control participants with a wide range of circulating 25(OH)D concentrations. For 30.1% of participants, 25(OH)D was newly measured. Previously measured 25(OH)D was calibrated to the same assay to permit estimating risk by absolute concentrations. Study-specific relative risks (RRs) for prediagnostic season-standardized 25(OH)D concentrations were calculated using conditional logistic regression and pooled using random effects models.Results: Compared with the lower range of sufficiency for bone health (50-<62.5 nmol/L), deficient 25(OH)D (<30 nmol/L) was associated with 31% higher colorectal cancer risk (RR = 1.31, 95% confidence interval [CI] = 1.05 to 1.62); 25(OH)D above sufficiency (75-<87.5 and 87.5-<100 nmol/L) was associated with 19% (RR = 0.81, 95% CI = 0.67 to 0.99) and 27% (RR = 0.73, 95% CI = 0.59 to 0.91) lower risk, respectively. At 25(OH)D of 100 nmol/L or greater, risk did not continue to decline and was not statistically significantly reduced (RR = 0.91, 95% CI = 0.67 to 1.24, 3.5% of control participants). Associations were minimally affected when adjusting for body mass index, physical activity, or other risk factors. For each 25 nmol/L increment in circulating 25(OH)D, colorectal cancer risk was 19% lower in women (RR = 0.81, 95% CI = 0.75 to 0.87) and 7% lower in men (RR = 0.93, 95% CI = 0.86 to 1.00) (two-sided Pheterogeneity by sex = .008). Associations were inverse in all subgroups, including colorectal subsite, geographic region, and season of blood collection.Conclusions: Higher circulating 25(OH)D was related to a statistically significant, substantially lower colorectal cancer risk in women and non-statistically significant lower risk in men. Optimal 25(OH)D concentrations for colorectal cancer risk reduction, 75-100 nmol/L, appear higher than current IOM recommendations. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
24. Associations Between Prediagnostic Concentrations of Circulating Sex Steroid Hormones and Esophageal/Gastric Cardia Adenocarcinoma Among Men.
- Author
-
Petrick, Jessica L, Hyland, Paula L, Caron, Patrick, Falk, Roni T, Pfeiffer, Ruth M, Dawsey, Sanford M, Abnet, Christian C, Taylor, Philip R, Weinstein, Stephanie J, Albanes, Demetrius, Freedman, Neal D, Gapstur, Susan M, Bradwin, Gary, Guillemette, Chantal, Campbell, Peter T, and Cook, Michael B
- Subjects
DEHYDROEPIANDROSTERONE ,SEX hormones ,TESTOSTERONE ,GENE expression ,ESTRADIOL - Abstract
Background: Esophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) are characterized by a strong male predominance. Concentrations of sex steroid hormones have been hypothesized to explain this sex disparity. However, no prospective population-based study has examined sex steroid hormones in relation to EA/GCA risk. Thus, we investigated whether prediagnostic circulating sex steroid hormone concentrations were associated with EA/GCA in a nested case-control study drawn from participants in three prospective cohort studies.Methods: Using gas chromatography-mass spectrometry (GC-MS) and electrochemiluminescence immunoassay, we quantitated sex steroid hormones and sex hormone binding globulin, respectively, in serum from 259 EA/GCA male case participants and 259 matched male control participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, and Cancer Prevention Study II Nutrition Cohort. Multivariable conditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between circulating hormones and EA/GCA risk. All statistical tests were two-sided.Results: Higher concentrations of dehydroepiandrosterone (DHEA) were associated with a 38% decreased risk of EA/GCA (OR per unit increase in log2 DHEA = 0.62, 95% CI = 0.47 to 0.82, Ptrend = .001). Higher estradiol concentrations were associated with a 34% reduced risk of EA/GCA (OR = 0.66, 95% CI = 0.45 to 0.98, Ptrend = .05), and the association with free estradiol was similar. No other associations between baseline hormone concentrations and future EA/GCA risk were observed.Conclusions: This study provides the first evidence that higher concentrations of circulating DHEA, estradiol, and free estradiol may be associated with lower risks of EA/GCA in men. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
25. Coffee Drinking and Cutaneous Melanoma Risk in the NIH-AARP Diet and Health Study
- Author
-
Loftfield, Erikka, primary, Freedman, Neal D., additional, Graubard, Barry I., additional, Hollenbeck, Albert R., additional, Shebl, Fatma M., additional, Mayne, Susan T., additional, and Sinha, Rashmi, additional
- Published
- 2015
- Full Text
- View/download PDF
26. Cigarette Smoking and Variations in Systemic Immune and Inflammation Markers
- Author
-
Shiels, Meredith S., primary, Katki, Hormuzd A., additional, Freedman, Neal D., additional, Purdue, Mark P., additional, Wentzensen, Nicolas, additional, Trabert, Britton, additional, Kitahara, Cari M., additional, Furr, Michael, additional, Li, Yan, additional, Kemp, Troy J., additional, Goedert, James J., additional, Chang, Cindy M., additional, Engels, Eric A., additional, Caporaso, Neil E., additional, Pinto, Ligia A., additional, Hildesheim, Allan, additional, and Chaturvedi, Anil K., additional
- Published
- 2014
- Full Text
- View/download PDF
27. Time to Smoke First Morning Cigarette and Lung Cancer in a Case–Control Study
- Author
-
Gu, Fangyi, primary, Wacholder, Sholom, additional, Kovalchik, Stephanie, additional, Panagiotou, Orestis A., additional, Reyes-Guzman, Carolyn, additional, Freedman, Neal D., additional, De Matteis, Sara, additional, Consonni, Dario, additional, Bertazzi, Pier Alberto, additional, Bergen, Andrew W., additional, Landi, Maria Teresa, additional, and Caporaso, Neil E., additional
- Published
- 2014
- Full Text
- View/download PDF
28. Nonsteroidal Anti-inflammatory Drug Use, Chronic Liver Disease, and Hepatocellular Carcinoma
- Author
-
Sahasrabuddhe, Vikrant V., primary, Gunja, Munira Z., additional, Graubard, Barry I., additional, Trabert, Britton, additional, Schwartz, Lauren M., additional, Park, Yikyung, additional, Hollenbeck, Albert R., additional, Freedman, Neal D., additional, and McGlynn, Katherine A., additional
- Published
- 2012
- Full Text
- View/download PDF
29. Body Mass Index and Risk of Lung Cancer Among Never, Former, and Current Smokers
- Author
-
Smith, Llewellyn, primary, Brinton, Louise A., additional, Spitz, Margaret R., additional, Lam, Tram Kim, additional, Park, Yikyung, additional, Hollenbeck, Albert R., additional, Freedman, Neal D., additional, and Gierach, Gretchen L., additional
- Published
- 2012
- Full Text
- View/download PDF
30. Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium
- Author
-
Cook, Michael B., primary, Kamangar, Farin, additional, Whiteman, David C., additional, Freedman, Neal D., additional, Gammon, Marilie D., additional, Bernstein, Leslie, additional, Brown, Linda M., additional, Risch, Harvey A., additional, Ye, Weimin, additional, Sharp, Linda, additional, Pandeya, Nirmala, additional, Webb, Penelope M., additional, Wu, Anna H., additional, Ward, Mary H., additional, Giffen, Carol, additional, Casson, Alan G., additional, Abnet, Christian C., additional, Murray, Liam J., additional, Corley, Douglas A., additional, Nyrén, Olof, additional, Vaughan, Thomas L., additional, and Chow, Wong-Ho, additional
- Published
- 2010
- Full Text
- View/download PDF
31. Time to Smoke First Morning Cigarette and Lung Cancer in a Case-Control Study.
- Author
-
Fangyi Gu, Wacholder, Sholom, Kovalchik, Stephanie, Panagiotou, Orestis A., Reyes-Guzman, Carolyn, Freedman, Neal D., De Matteis, Sara, Consonni, Dario, Bertazzi, Pier Alberto, Bergen, Andrew W., Landi, Maria Teresa, and Caporaso, Neil E.
- Subjects
LUNG cancer ,CANCER risk factors ,MEDICAL screening ,SMOKING ,CIGARETTE smokers - Abstract
Background Targeting smokers at higher lung cancer risk can improve efficiency and reduce false-positive detection in lung cancer screening. We evaluated whether time to first cigarette after waking (TTFC), a single-item measure of nicotine dependency, could improve stratification of lung cancer risk beyond standard smoking metrics (intensity, duration, and pack-years). Methods In 3249 ever-smokers (n = 1812 case subjects; n = 1437 control subjects) from a population-based case-control study in Italy, we examined the association between TTFC and lung cancer using logistic regression and estimated lung cancer incidence by levels of TTFC, and intensity, duration, and pack-years using absolute risk regression. Significance tests were two-sided. Results Compared with smokers with TTFC greater than 60 minutes, the lung cancer odds ratios for TTFC of 31 to 60 minutes, 6 to 30 minutes, and 5 or fewer minutes (by increasing dependency) were 2.57 (95% confidence interval [CI] = 2.03 to 3.26), 2.27 (95% CI = 1.79 to 2.88), and 3.50 (95% CI = 2.64 to 4.64), respectively (P
trend < .0001).The average lung cancer incidence rates for smokers of 1 to 10,11 to 20, 21 to 30 and more than 30 cigarettes per day were consistently higher among smokers with TTFC of 60 or fewer minutes vs more than 60 minutes (64.1 vs 11.7; 125.6 vs 28.6; 130.1 vs 40.7; and 260.8 vs 108.9 per 100000 person-years, respectively).The slopes of increase in lung cancer rates with smoking duration and pack-years were statistically significantly greater among smokers with higher dependency (Pinteraction < .001). Conclusions Lung cancer risk increases with shorter TTFC; this simple nicotine dependency measure increases lung cancer risk stratification beyond standard smoking measures. Assessing TTFC may improve lung cancer risk prediction and could be useful in lung cancer screening and smoking cessation programs. [ABSTRACT FROM AUTHOR]- Published
- 2014
- Full Text
- View/download PDF
32. Response.
- Author
-
Sahasrabuddhe, Vikrant V, Gunja, Munira Z, Graubard, Barry I, Trabert, Britton, Schwartz, Lauren M, Park, Yikyung, Hollenbeck, Albert R, Freedman, Neal D, and McGlynn, Katherine A
- Published
- 2013
33. The Relationship Between Serum Ghrelin and the Risk of Gastric and Esophagogastric Junctional Adenocarcinomas.
- Author
-
Murphy, Gwen, Kamangar, Farin, Dawsey, Sanford M., Stanczyk, Frank Z., Weinstein, Stephanie J., Taylor, Philip R., Virtamo, Jarmo, Abnet, Christian C., Albanes, Demetrius, and Freedman, Neal D.
- Subjects
CANCER research ,GHRELIN ,ADENOCARCINOMA ,STOMACH cancer ,ESOPHAGOGASTRIC junction cancer - Abstract
Background Cancers of the upper gastrointestinal tract remain a substantial cause of morbidity and mortality worldwide. Ghrelin is a hormone produced in the oxyntic glands of the stomach, and under conditions of chronic inflammation and atrophy, serum ghrelin concentrations decrease. However, the relationship between ghrelin and the risk of gastric and esophagogastric junctional cancers has not been investigated. Methods We conducted a nested case–control study within the Finnish Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study to examine the relationship between serum ghrelin concentration and the risk of gastric noncardia adenocarcinoma (GNCA) and esophagogastric junctional adenocarcinoma (EGJA). Data from 261 GNCA patients, 98 EGJA patients, and 441 control subjects were analyzed. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated using logistic regression with adjustment for potential confounders. Lag analysis was also performed to investigate the temporal nature of the associations between baseline serum pepsinogen I and ghrelin in GNCA and EGJA patients. All statistical tests were two-sided. Results Lower concentrations of serum ghrelin were statistically significantly associated with an increased risk of both GNCA (adjusted OR = 1.75, 95% CI = 1.49 to 2.04; P < .001) and EGJA (adjusted OR = 1.56, 95% CI = 1.28 to 1.89, P < .001). A multivariable model found that the risk of both GNCA and EGJA were statistically significantly increased for those individuals in the lowest quartile of serum ghrelin levels compared with those in the highest quartile (OR of GNCA = 5.63, 95% CI = 3.16 to 10.03; OR of EGJA = 4.90, 95% CI = 2.11 to 11.35). The statistical significance of these associations remained even after restricting the analysis to those patients who developed cancer more than 10 years after baseline serum ghrelin measurements. Conclusion Low baseline concentrations of serum ghrelin were associated with a statistically significant increase in the risk of GNCA and EGJA, suggesting a potential role for gastric hormones in carcinogenesis. [ABSTRACT FROM PUBLISHER]
- Published
- 2011
- Full Text
- View/download PDF
34. Association of Meat and Fat Intake With Liver Disease and Hepatocellular Carcinoma in the NIH-AARP Cohort.
- Author
-
Freedman, Neal D., Cross, Amanda J., McGlynn, Katherine A., Abnet, Christian C., Yikyung Park, Hollenbeck, Albert R., Schatzkin, Arthur, Everhart, James E., and Sinha, Rashmi
- Subjects
- *
MEAT industry , *LIVER diseases , *LIVER cancer , *AMINES , *NITROSO compounds , *PYRIDINE , *IMIDAZOLES - Abstract
Background Several plausible mechanisms, including fat, iron, heterocyclic amines, and N-nitroso compounds, link meat intake with chronic liver disease (CLD) and hepatocellular carcinoma (HCC). Few studies have investigated these associations. Methods We prospectively examined the relationship between meat and associated exposures with CLD mortality (n = 551; not including HCC) and HCC incidence (n = 338) in 495 006 men and women of the National Institutes of Health-AARP Diet and Health Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the fifth (Q5) vs the first (Q1) quintile were estimated from multivariable adjusted Cox proportional hazards regression models. All tests of statistical significance were two-sided. Results We found inverse associations between white meat and risk of CLD (HR = 0.52, 95% CI = 0.39 to 0.70, 7.5 vs 18.2 cases per 100 000 person-years) and HCC (HR = 0.52, 95% CI = 0.36 to 0.77, 5.8 vs 14.3 cases per 100 000 personyears). Red meat was associated with higher risk of CLD (HR = 2.59, 95% CI = 1.86 to 3.61, 22.3 vs 6.2 cases per 100 000 person-years) and HCC (HR = 1.74, 95% CI = 1.16 to 2.61, 14.9 vs 5.7 cases per 100 000 person-years). Among fat types, results were strongest for saturated fat (for CLD, HR = 3.50, 95% CI = 2.48 to 4.96, 23.0 vs 6.5 cases per 100 000 person-years; for HCC, HR = 1.87, 95% CI = 1.23 to 2.85, 14.5 vs 6.3 cases per 100 000 personyears). After mutual adjustment, risk estimates persisted for saturated fat, red meat, and white meat. Heme iron, processed meat, nitrate, and nitrite were positively associated with CLD but not with HCC. Individual heterocyclic amines, 2-amino-3,4,8-trimethylimidazo[4,5,-f]quinoxaline (DiMeIQx), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx), and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), were not associated with either outcome. Conclusion Our results suggest that red meat and saturated fat may be associated with increased CLD and HCC risk, whereas white meat may be associated with reduced risk. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
35. RE: Time to Smoke First Morning Cigarette (TTFC) and Lung Cancer in a Case-Control Study.
- Author
-
FANGYI GU, WACHOLDER, SHOLOM, FREEDMAN, NEAL D., PANAGIOTOU, ORESTIS A., REYES-GUZMAN, CAROLYN, BERTAZZI, PIER ALBERTO, and CAPORASO, NEIL E.
- Subjects
HEALTH ,SMOKING ,LUNG cancer risk factors - Abstract
A response from the authors of the article "Time to Smoke First Morning Cigarette (TTFC) and Lung Cancer in a Case-Control Study" in the 2014 issue is presented.
- Published
- 2014
- Full Text
- View/download PDF
36. Response.
- Author
-
Gu, Fangyi, Wacholder, Sholom, Freedman, Neal D, Panagiotou, Orestis A, Reyes-Guzman, Carolyn, Bertazzi, Pier Alberto, and Caporaso, Neil E
- Published
- 2014
- Full Text
- View/download PDF
37. Response.
- Author
-
Smith, Llewellyn, Brinton, Louise A., Freedman, Neal D., and Gierach, Gretchen L.
- Subjects
LETTERS to the editor ,BODY mass index ,LUNG cancer risk factors - Abstract
A response by Llewellyn Smith and colleagues to a letter to the editor about their study on the association between body mass index and lung cancer risk among smokers in this issue of the journal is presented.
- Published
- 2012
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.