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Objective: The objective was to develop a diaper cream for children under 3 years old, meeting strict safety and regulatory standards, and ensuring physical, chemical and microbiological stability. Methods: The active substances as well as the excipients were rigorously selected. The critical HLB value of sweet almond oil has been determined. The operating parameters were optimized, in particular the temperature and time of addition of active substances, as well as the final stirring time. Physico-chemical and microbiological controls were carried out. Results: The HLBc value determined corresponded to that in the literature. The zinc oxide incorporated into the mixture of the two phases after cooling and the calendula extract incorporated into the aqueous phase before heating made it possible to obtain the most stable formulation. The final stirring time was set. The physicochemical and microbiological controls were compliant. Conclusion: The developed cream is suitable for children thanks to its safe composition and its microbiological, chemical and physical stability. [ABSTRACT FROM AUTHOR]

One can present logistics today as being the functions of planning, execution and control of the flows of goods and information for the acquisition, storage, movement and delivery of goods while cooperating with the other members of the chain to achieve the goals expected from the supply chain, in particular the decrease of time to market. The supply chain is the sequence of units connected and crossed by physical flows, information flows, or financial information flows, and whose activities contribute to making available tangible or intangible product to the end customers. As a result of the many changes currently taking place in the healthcare sector, hospitals need to optimize their management to reduce expenses while ensuring the safety and quality of patient care. Pharmaceutical logistics is an important part of the hospital budget, and cost savings can be made. This paper is focused on logistics, the supply chain and more specifically the pharmaceutical logistics. At first, we will define the general framework of the logistics. In a second step, we will discuss the different functions of the supply chain. We will then present the pharmaceutical supply chain and its specificities. [ABSTRACT FROM AUTHOR]