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This article examines the gradual evolution of the French Régulation school (FR) for the study of capitalism through the lens of structure and agency. The analysis first segments the school into two epochs, the early Régulation, led by authors Aglietta and Lipietz, and the later Régulation, which saw the rise of Boyer. We find that the gradual progression that occurred within the FR school is linked to its authors' implicit ontic engagement with structure and agency, which, in turn, provides natural linkages to Critical Realism. In the second part of the paper, we demonstrate how the comparison between Morphogenetic Régulation and French Régulation (FR) can facilitate a much deeper reading of the structure‐agency debate pertaining to the transformation of capitalism. In so doing, it discusses the value addedness of Morphogenetic Régulation through three specific concepts by stressing their relevance for contemporary studies in international political economy. These concepts are: stratified emergence; causality and the problématique of hierarchy. [ABSTRACT FROM AUTHOR]