1. HTLV-I/II Seropositivity in Populations at High Risk for HIV-1 Infection in Cordoba City, Argentina
- Author
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Miguel O. Giordano, Eduardo Maturano, Silvia Nates, Silvia Medeot, Yamile Recalde, Sandra Gallego, Raul Bocangel Alvarez, and Santos Sileoni
- Subjects
Blood transfusion ,viruses ,medicine.medical_treatment ,Blotting, Western ,Immunology ,Population ,Argentina ,Human immunodeficiency virus (HIV) ,HIV Infections ,medicine.disease_cause ,Risk Factors ,Seroepidemiologic Studies ,immune system diseases ,Agglutination Tests ,hemic and lymphatic diseases ,Virology ,HIV Seropositivity ,Prevalence ,medicine ,Humans ,Immunology and Allergy ,Htlv i ii ,Seroprevalence ,Fluorescent Antibody Technique, Indirect ,education ,education.field_of_study ,biology ,business.industry ,virus diseases ,Serum samples ,HTLV-I Infections ,HTLV-I Antibodies ,HTLV-II Antibodies ,Agglutination (biology) ,HTLV-II Infections ,HIV-1 ,biology.protein ,Antibody ,business - Abstract
Recent epidemiologic studies in Buenos Aires suggest the presence of HTLV-I/II in blood banks and in the population at risk for HIV-1 infection with seroprevalence of 4% among IV drug users 0.5% in homosexual men and 0.1% in blood donors. However neither blood nor blood derivatives in Argentina are screened for these agents. Findings are presented from an HTLV-I/II seroprevalence survey conducted in Cordoba City Argentina. 312 serum samples collected during 1985-95 from HIV-1-positive subjects and others exposed to HIV through blood transfusion were screened for antibodies to HTLV-I/II. Of 10 sera reactive to Serodia HTLV-I particulate agglutination (PA) assay 6 were confirmed HTLV-I-positive and 1 was confirmed HTLV-II-positive by indirect immunofluorescence assay (IFA). Of 6 HTLV-I-positive samples on IFA 5 were confirmed positive by Western blot (WB) but 1 sample was not tested. The IFA HTLV-II-positive sample was indeterminate with a weak reaction to the p24 and p19 HTLV-I proteins. Blood banks should screen for the presence of HTLV-I/II infection in blood supplies in order to prevent their widespread dissemination in the population.
- Published
- 1998
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