1. Association of Alcohol Use Biomarkers and Cognitive Performance in Veterans With Problematic Alcohol Use and Posttraumatic Stress Disorder: Data From the Mind Your Heart Study
- Author
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Kalapatapu, Raj K, Neylan, Thomas C, Regan, Mathilda C, and Cohen, Beth E
- Subjects
Clinical and Health Psychology ,Psychology ,Anxiety Disorders ,Mental Illness ,Substance Misuse ,Mental Health ,Alcoholism ,Alcohol Use and Health ,Post-Traumatic Stress Disorder (PTSD) ,Behavioral and Social Science ,Brain Disorders ,Mental health ,Cardiovascular ,Good Health and Well Being ,Adult ,Aged ,Alanine Transaminase ,Alcohol-Related Disorders ,Aspartate Aminotransferases ,Biomarkers ,Cognition ,Erythrocyte Indices ,Female ,Humans ,Male ,Middle Aged ,Stress Disorders ,Post-Traumatic ,Veterans ,Alcohol use biomarkers ,cognitive performance ,problematic alcohol use ,posttraumatic stress disorder ,Public Health and Health Services ,Substance Abuse ,Public health ,Clinical and health psychology - Abstract
The authors conducted a study of alcohol use biomarkers and cognitive performance among 85 veterans with problematic alcohol use and posttraumatic stress disorder (PTSD). All analyses were adjusted for demographics, depression, anxiety, and PTSD symptoms. Elevated levels of aspartate aminotransferase were associated with worse performance on the Trail Making Test Part A and Hopkins Verbal Learning Test. Two other biomarkers were not associated with any neurocognitive measures. Indirect alcohol use biomarkers (e.g., aspartate aminotransferase) may have a specific role in identifying veterans with problematic alcohol use and PTSD who show a change in psychomotor speed and immediate verbal memory performance.
- Published
- 2014